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Article: Molecular changes during arsenic-induced cell transformation

TitleMolecular changes during arsenic-induced cell transformation
Authors
Issue Date2011
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31010
Citation
Journal of Cellular Physiology, 2011, v. 226 n. 12, p. 3225-3232 How to Cite?
AbstractArsenic and its derivatives are naturally occurring metalloid compounds widely distributed in the environment. Arsenics are known to cause cancers of the skin, liver, lung, kidney, and bladder. Although numerous carcinogenic pathways have been proposed, the exact molecular mechanisms remain to be delineated. To further characterize the role of oxidative stress in arsenite-induced cell transformation via the reactive oxygen species (ROS)-mediated Ras/Erk pathway, here we demonstrated arsenite-induced rat lung epithelial cell (LEC) transformation, epithelial-mesenchymal transition, stimulation of the extracellular signal-regulated kinase signaling pathway, and enhancement of cell proliferation. However, there was no evidence of activation of the phosphoinositide 3-kinase/protein kinase B pathway in arsenite-induced transformed LECs. Since ROS is involved in arsenite-induced LEC cell transformation, Redox-status regulatory proteins (Cu/Zn SOD and thioredoxin) and arsenite-induced LEC cell transformation were significantly inhibited by concurrent treatment with the antioxidants. Our experimental results clearly demonstrated that induction of p-ERK and cell proliferation by arsenite is mediated via oxidative stress, since antioxidants can inhibit arsenite-induced cell transformation.
Persistent Identifierhttp://hdl.handle.net/10722/137204
ISSN
2015 Impact Factor: 4.155
2015 SCImago Journal Rankings: 1.842
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Gen_HK
dc.contributor.authorLee, LSen_HK
dc.contributor.authorLi, Men_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorChiu, JFen_HK
dc.date.accessioned2011-08-26T14:18:47Z-
dc.date.available2011-08-26T14:18:47Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal of Cellular Physiology, 2011, v. 226 n. 12, p. 3225-3232en_HK
dc.identifier.issn0021-9541en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137204-
dc.description.abstractArsenic and its derivatives are naturally occurring metalloid compounds widely distributed in the environment. Arsenics are known to cause cancers of the skin, liver, lung, kidney, and bladder. Although numerous carcinogenic pathways have been proposed, the exact molecular mechanisms remain to be delineated. To further characterize the role of oxidative stress in arsenite-induced cell transformation via the reactive oxygen species (ROS)-mediated Ras/Erk pathway, here we demonstrated arsenite-induced rat lung epithelial cell (LEC) transformation, epithelial-mesenchymal transition, stimulation of the extracellular signal-regulated kinase signaling pathway, and enhancement of cell proliferation. However, there was no evidence of activation of the phosphoinositide 3-kinase/protein kinase B pathway in arsenite-induced transformed LECs. Since ROS is involved in arsenite-induced LEC cell transformation, Redox-status regulatory proteins (Cu/Zn SOD and thioredoxin) and arsenite-induced LEC cell transformation were significantly inhibited by concurrent treatment with the antioxidants. Our experimental results clearly demonstrated that induction of p-ERK and cell proliferation by arsenite is mediated via oxidative stress, since antioxidants can inhibit arsenite-induced cell transformation.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31010en_HK
dc.relation.ispartofJournal of Cellular Physiologyen_HK
dc.rightsJournal of Cellular Physiology. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshArsenites - toxicityen_HK
dc.subject.meshCarcinogens, Environmental - toxicityen_HK
dc.subject.meshCell Transformation, Neoplastic - chemically induced - metabolism - pathologyen_HK
dc.subject.meshEpithelial Cells - drug effects - metabolism - pathologyen_HK
dc.subject.meshEpithelial-Mesenchymal Transition - drug effectsen_HK
dc.titleMolecular changes during arsenic-induced cell transformationen_HK
dc.typeArticleen_HK
dc.identifier.emailTsao, SW: gswtsao@hku.hken_HK
dc.identifier.emailChiu, JF: jfchiu@hkucc.hku.hk-
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jcp.22683en_HK
dc.identifier.pmid21344382-
dc.identifier.scopuseid_2-s2.0-79958140770en_HK
dc.identifier.hkuros191898en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79958140770&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume226en_HK
dc.identifier.issue12en_HK
dc.identifier.spage3225en_HK
dc.identifier.epage3232en_HK
dc.identifier.isiWOS:000296458100015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChiu, JF=7201501692en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridLi, M=7405264639en_HK
dc.identifier.scopusauthoridLee, LS=54408918600en_HK
dc.identifier.scopusauthoridLi, G=43161253800en_HK

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