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Article: Peripheral nerve injury alters the expression of NF-κB in the rat's hippocampus

TitlePeripheral nerve injury alters the expression of NF-κB in the rat's hippocampus
Authors
KeywordsHippocampus
Neuropathic pain
NF-κB
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2011, v. 1378, p. 66-71 How to Cite?
AbstractThe hippocampus plays an important role in learning and memory and possibly contributes to the formation of pain-related memory and emotional responses. However, there is currently little data linking the hippocampus to neuropathic pain. It has been reported that NF-κB is an important regulatory factor in memory consolidation within the hippocampus. This study aims to examine a possible relationship between the hippocampal NF-κB expression and nerve injury-induced thermal hyperalgesia using a rat model of constriction sciatic nerve injury (CCI). Immunofluorescence and Western blot analysis were performed to detect and quantify the hippocampal NF-κB expression. Thermal hyperalgesia was examined on day 0 and postoperative days 1, 7 and 14. The nuclear portion of the p65 NF-κB expression was significantly increased on the contralateral side on days 7 and 14 as well as significantly increased on the ipsilateral side on day 14 as compared to the sham control group. Intraperitoneal administration of MK-801, an N-methyl-d-aspartate (NMDA) receptor antagonist, reduced hyperalgesia and modulated the NF-κB expression in the contralateral side of hippocampus. These results suggest an association between the hippocampal NF-κB expression and the behavioral manifestation of thermal hyperalgesia, which is likely to be mediated through activation of the NMDA receptor. © 2011 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/137188
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
NIHDE18214
DE18538
N545681
Funding Information:

This study is supported by NIH RO1 grants DE18214, DE18538, and N545681. The authors claim no conflict of interest.

References

 

DC FieldValueLanguage
dc.contributor.authorChou, CWen_HK
dc.contributor.authorWong, GTCen_HK
dc.contributor.authorLim, Gen_HK
dc.contributor.authorMcCabe, MFen_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorMao, Jen_HK
dc.date.accessioned2011-08-26T14:18:16Z-
dc.date.available2011-08-26T14:18:16Z-
dc.date.issued2011en_HK
dc.identifier.citationBrain Research, 2011, v. 1378, p. 66-71en_HK
dc.identifier.issn0006-8993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137188-
dc.description.abstractThe hippocampus plays an important role in learning and memory and possibly contributes to the formation of pain-related memory and emotional responses. However, there is currently little data linking the hippocampus to neuropathic pain. It has been reported that NF-κB is an important regulatory factor in memory consolidation within the hippocampus. This study aims to examine a possible relationship between the hippocampal NF-κB expression and nerve injury-induced thermal hyperalgesia using a rat model of constriction sciatic nerve injury (CCI). Immunofluorescence and Western blot analysis were performed to detect and quantify the hippocampal NF-κB expression. Thermal hyperalgesia was examined on day 0 and postoperative days 1, 7 and 14. The nuclear portion of the p65 NF-κB expression was significantly increased on the contralateral side on days 7 and 14 as well as significantly increased on the ipsilateral side on day 14 as compared to the sham control group. Intraperitoneal administration of MK-801, an N-methyl-d-aspartate (NMDA) receptor antagonist, reduced hyperalgesia and modulated the NF-κB expression in the contralateral side of hippocampus. These results suggest an association between the hippocampal NF-κB expression and the behavioral manifestation of thermal hyperalgesia, which is likely to be mediated through activation of the NMDA receptor. © 2011 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_HK
dc.relation.ispartofBrain Researchen_HK
dc.subjectHippocampusen_HK
dc.subjectNeuropathic painen_HK
dc.subjectNF-κBen_HK
dc.subject.meshFunctional Laterality - physiology-
dc.subject.meshHippocampus - metabolism-
dc.subject.meshHyperalgesia - metabolism-
dc.subject.meshNF-kappa B - biosynthesis-
dc.subject.meshNeuralgia - metabolism-
dc.titlePeripheral nerve injury alters the expression of NF-κB in the rat's hippocampusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-8993&volume=1378&spage=66&epage=71&date=2011&atitle=Peripheral+nerve+injury+alters+the+expression+of+NF-κB+in+the+rat%27s+hippocampus-
dc.identifier.emailWong, GTC:gordon@hku.hken_HK
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_HK
dc.identifier.authorityWong, GTC=rp00523en_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1016/j.brainres.2011.01.006en_HK
dc.identifier.pmid21223950-
dc.identifier.pmcidPMC3042522-
dc.identifier.scopuseid_2-s2.0-79951957249en_HK
dc.identifier.hkuros191619en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79951957249&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1378en_HK
dc.identifier.spage66en_HK
dc.identifier.epage71en_HK
dc.identifier.isiWOS:000288730300007-
dc.publisher.placeNetherlandsen_HK

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