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Article: Prunus mume extract exhibits antimicrobial activity against pathogenic oral bacteria

TitlePrunus mume extract exhibits antimicrobial activity against pathogenic oral bacteria
Authors
Issue Date2011
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0960-7439
Citation
International Journal Of Paediatric Dentistry, 2011, v. 21 n. 4, p. 299-305 How to Cite?
AbstractObjectives. Prunus mume is a common fruit in Asia, which has been used in traditional Chinese medicine. In this study, we focused on the antimicrobial properties of Prunus mume extract against oral pathogens related to dental caries and periodontal diseases. Study design. A total of 15 oral pathogens including Streptococcus mutans, S. sobrinus, S. mitis, S. sanguinis, Lactobacillus acidophilus, P. gingivalis, Aggregatibacter actinomycetemcomitans, and Candida species were included in the study. Initially, agar diffusion assay was performed to screen the antimicrobial activities of Prunus mume extract. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were then determined for sensitive species. Effect of Prunus mume extract on human oral keratinocytes (HOK) viability was also tested. Result. In the agar diffusion assay, drug suspension of 2g/mL was able to inhibit all the bacterial species tested, but not the fungal species. MIC and MBC range of Prunus mume extract against the oral bacteria was 0.15625-0.0003g/mL and P. gingivalis being the most susceptible species. Prune extract did not cause any detrimental effect on HOK. Conclusion. Prunus mume extract may be a potential candidate for developing an oral antimicrobial agent to control or prevent dental diseases associated with oral pathogenic bacteria. © 2011 The Authors. International Journal of Paediatric Dentistry © 2011 BSPD, IAPD and Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/137186
ISSN
2015 Impact Factor: 1.303
2015 SCImago Journal Rankings: 0.721
ISI Accession Number ID
Funding AgencyGrant Number
International Association for Dental Research/GlaxoSmithKline
Funding Information:

This study was supported by the 2008 Innovation in Oral Care Awards (International Association for Dental Research/GlaxoSmithKline). We thank Ms J. Yau and Raymond Tong for the technical assistance.

References

 

DC FieldValueLanguage
dc.contributor.authorSeneviratne, CJen_HK
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorHägg, Uen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorHerath, TDKen_HK
dc.contributor.authorLakshman Samaranayake, Pen_HK
dc.contributor.authorKao, Ren_HK
dc.date.accessioned2011-08-26T14:18:08Z-
dc.date.available2011-08-26T14:18:08Z-
dc.date.issued2011en_HK
dc.identifier.citationInternational Journal Of Paediatric Dentistry, 2011, v. 21 n. 4, p. 299-305en_HK
dc.identifier.issn0960-7439en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137186-
dc.description.abstractObjectives. Prunus mume is a common fruit in Asia, which has been used in traditional Chinese medicine. In this study, we focused on the antimicrobial properties of Prunus mume extract against oral pathogens related to dental caries and periodontal diseases. Study design. A total of 15 oral pathogens including Streptococcus mutans, S. sobrinus, S. mitis, S. sanguinis, Lactobacillus acidophilus, P. gingivalis, Aggregatibacter actinomycetemcomitans, and Candida species were included in the study. Initially, agar diffusion assay was performed to screen the antimicrobial activities of Prunus mume extract. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were then determined for sensitive species. Effect of Prunus mume extract on human oral keratinocytes (HOK) viability was also tested. Result. In the agar diffusion assay, drug suspension of 2g/mL was able to inhibit all the bacterial species tested, but not the fungal species. MIC and MBC range of Prunus mume extract against the oral bacteria was 0.15625-0.0003g/mL and P. gingivalis being the most susceptible species. Prune extract did not cause any detrimental effect on HOK. Conclusion. Prunus mume extract may be a potential candidate for developing an oral antimicrobial agent to control or prevent dental diseases associated with oral pathogenic bacteria. © 2011 The Authors. International Journal of Paediatric Dentistry © 2011 BSPD, IAPD and Blackwell Publishing Ltd.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0960-7439en_HK
dc.relation.ispartofInternational Journal of Paediatric Dentistryen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.comen_US
dc.titlePrunus mume extract exhibits antimicrobial activity against pathogenic oral bacteriaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1365-263X&volume=21&issue=4&spage=299&epage=305&date=2011&atitle=Prunus+mume+extract+exhibits+antimicrobial+activity+against+pathogenic+oral+bacteriaen_US
dc.identifier.emailSeneviratne, CJ:jaya@hku.hken_HK
dc.identifier.emailWong, RWK:fyoung@hkucc.hku.hken_HK
dc.identifier.emailHägg, U:euohagg@hkusua.hku.hken_HK
dc.identifier.emailKao, R:rytkao@hkucc.hku.hken_HK
dc.identifier.authoritySeneviratne, CJ=rp01372en_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.identifier.authorityKao, R=rp00481en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-263X.2011.01123.xen_HK
dc.identifier.pmid21401748-
dc.identifier.scopuseid_2-s2.0-79957919050en_HK
dc.identifier.hkuros199077en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79957919050&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue4en_HK
dc.identifier.spage299en_HK
dc.identifier.epage305en_HK
dc.identifier.isiWOS:000291224000009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSeneviratne, CJ=6701897753en_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK
dc.identifier.scopusauthoridChen, Y=54392761900en_HK
dc.identifier.scopusauthoridHerath, TDK=40561255100en_HK
dc.identifier.scopusauthoridLakshman Samaranayake, P=54393259500en_HK
dc.identifier.scopusauthoridKao, R=7101675499en_HK
dc.identifier.citeulike9402371-

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