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Article: Antifungal Susceptibility and Virulence Attributes of Bloodstream Isolates of Candida from Hong Kong and Finland

TitleAntifungal Susceptibility and Virulence Attributes of Bloodstream Isolates of Candida from Hong Kong and Finland
Authors
KeywordsAntifungal
Bloodstream isolates
Candida
Virulence attributes
Issue Date2011
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0301-486X
Citation
Mycopathologia, 2011, v. 172 n. 5, p. 389-395 How to Cite?
AbstractCandida bloodstream infection has dramatically increased in the last decade due to the growing number of immunocompromised populations worldwide. In this study, we evaluated the antifungal susceptibility profiles and virulence attributes of Candida bloodstream isolates (CBIs) derived from Hong Kong and Finland, information which are vital for devising empirical clinical strategies. Susceptibility testing of a wide range of antifungals including fluconazole, itraconazole, voriconazole, ketoconazole, 5-fluorocytosine, amphotericin B and caspofungin was performed. Haemolytic activity and secretion of proteinase of CBIs were also examined. All CBIs derived from Hong Kong were susceptible to all the antifungals tested whilst some CBIs from Finland were resistant to azoles and caspofungin. C. albicans, C. glabrata and C. tropicalis showed higher haemolytic activity whereas C. parapsilosis and C. guilliermondii were non-haemolytic in general. Proteinase activity of the Finland C. albicans isolates was significantly higher than the Hong Kong isolates. Our data provide a glimpse of the possible evolutionary changes in pathogenic potential of Candida that may be occurring in different regions of the world. Therefore, continuous surveillance and availability of local data should be taken into consideration when treating candidemia patients. © 2011 Springer Science+Business Media B.V.
Persistent Identifierhttp://hdl.handle.net/10722/137183
ISSN
2015 Impact Factor: 1.671
2015 SCImago Journal Rankings: 0.720
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants Council, RGCHKU 7624/06 M
Helsinki University Central HospitalTYH3245
Funding Information:

This work was supported by the Hong Kong Research Grants Council, RGC No. HKU 7624/06 M and by the EVO Grant TYH3245 by the Helsinki University Central Hospital.

References

 

DC FieldValueLanguage
dc.contributor.authorSeneviratne, CJen_HK
dc.contributor.authorWong, SSWen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorMeurman, JHen_HK
dc.contributor.authorPärnänen, Pen_HK
dc.contributor.authorVaara, Men_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2011-08-26T14:18:07Z-
dc.date.available2011-08-26T14:18:07Z-
dc.date.issued2011en_HK
dc.identifier.citationMycopathologia, 2011, v. 172 n. 5, p. 389-395en_HK
dc.identifier.issn0301-486Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/137183-
dc.description.abstractCandida bloodstream infection has dramatically increased in the last decade due to the growing number of immunocompromised populations worldwide. In this study, we evaluated the antifungal susceptibility profiles and virulence attributes of Candida bloodstream isolates (CBIs) derived from Hong Kong and Finland, information which are vital for devising empirical clinical strategies. Susceptibility testing of a wide range of antifungals including fluconazole, itraconazole, voriconazole, ketoconazole, 5-fluorocytosine, amphotericin B and caspofungin was performed. Haemolytic activity and secretion of proteinase of CBIs were also examined. All CBIs derived from Hong Kong were susceptible to all the antifungals tested whilst some CBIs from Finland were resistant to azoles and caspofungin. C. albicans, C. glabrata and C. tropicalis showed higher haemolytic activity whereas C. parapsilosis and C. guilliermondii were non-haemolytic in general. Proteinase activity of the Finland C. albicans isolates was significantly higher than the Hong Kong isolates. Our data provide a glimpse of the possible evolutionary changes in pathogenic potential of Candida that may be occurring in different regions of the world. Therefore, continuous surveillance and availability of local data should be taken into consideration when treating candidemia patients. © 2011 Springer Science+Business Media B.V.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0301-486Xen_HK
dc.relation.ispartofMycopathologiaen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectAntifungalen_HK
dc.subjectBloodstream isolatesen_HK
dc.subjectCandidaen_HK
dc.subjectVirulence attributesen_HK
dc.titleAntifungal Susceptibility and Virulence Attributes of Bloodstream Isolates of Candida from Hong Kong and Finlanden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0301-486X&volume=172&issue=5&spage=389&epage=395&date=2011&atitle=Antifungal+susceptibility+and+virulence+attributes+of+bloodstream+isolates+of+Candida+from+Hong+Kong+and+Finland-
dc.identifier.emailSeneviratne, CJ:jaya@hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySeneviratne, CJ=rp01372en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11046-011-9444-4en_HK
dc.identifier.pmid21744043en_HK
dc.identifier.scopuseid_2-s2.0-80053950480en_HK
dc.identifier.hkuros191869en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053950480&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume172en_HK
dc.identifier.issue5en_HK
dc.identifier.spage389en_HK
dc.identifier.epage395en_HK
dc.identifier.isiWOS:000297626000007-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridSeneviratne, CJ=6701897753en_HK
dc.identifier.scopusauthoridWong, SSW=7404590651en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridMeurman, JH=7006469347en_HK
dc.identifier.scopusauthoridPärnänen, P=24344880300en_HK
dc.identifier.scopusauthoridVaara, M=7006044173en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.citeulike9548767-

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