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Article: Localization of brain activation by umami taste in humans

TitleLocalization of brain activation by umami taste in humans
Authors
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2011, v. 1406, p. 18-29 How to Cite?
Abstract
There are no credible data to support the notion that individual taste qualities have dedicated pathways leading from the tongue to the end of the pathway in the brain. Moreover, the insular cortex is activated not only by taste but also by non-taste information from oral stimuli. These responses are invariably excitatory, and it is difficult to determine whether they are sensory, motor, or proprioceptive in origin. Furthermore, umami is a more unfamiliar and complex taste than other basic tastes. Considering these issues, it may be effective to minimize somatosensory stimuli, oral movement, and psychological effects in a neuroimaging study to elicit cerebral activity by pure umami on the human tongue. For this purpose, we developed an original taste delivery system for functional magnetic resonance imaging (fMRI) studies for umami. Then, we compared the results produced by two authorized models, namely, the block design model and event-related design model, to decide the appropriate model for detecting activation by umami. Activation by the umami taste was well localized in the insular cortex using our new system and block design model analysis. The peaks of the activated areas in the middle insular cortex by umami were very close to another prototypical taste quality (salty). Although we have to carefully interpret the perceiving intensities and brain activations by taste from different sessions, this study design might be effective for detecting the accession area in the cortex of pure umami taste on the tongue. © 2011 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/137181
ISSN
2013 Impact Factor: 2.828
2013 SCImago Journal Rankings: 1.572
ISI Accession Number ID
Funding AgencyGrant Number
Ministry of Education, Japan19390479
Society for Research on Umami Taste
Funding Information:

This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Japan (19390479 to TK.G.) and Society for Research on Umami Taste (to TK.G.).

References

 

Author Affiliations
  1. Kyushu University
  2. Kyushu University Hospital
DC FieldValueLanguage
dc.contributor.authorNakamura, Yen_HK
dc.contributor.authorGoto, TKen_HK
dc.contributor.authorTokumori, Ken_HK
dc.contributor.authorYoshiura, Ten_HK
dc.contributor.authorKobayashi, Ken_HK
dc.contributor.authorNakamura, Yen_HK
dc.contributor.authorHonda, Hen_HK
dc.contributor.authorNinomiya, Yen_HK
dc.contributor.authorYoshiura, Ken_HK
dc.date.accessioned2011-08-26T14:18:05Z-
dc.date.available2011-08-26T14:18:05Z-
dc.date.issued2011en_HK
dc.identifier.citationBrain Research, 2011, v. 1406, p. 18-29en_HK
dc.identifier.issn0006-8993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137181-
dc.description.abstractThere are no credible data to support the notion that individual taste qualities have dedicated pathways leading from the tongue to the end of the pathway in the brain. Moreover, the insular cortex is activated not only by taste but also by non-taste information from oral stimuli. These responses are invariably excitatory, and it is difficult to determine whether they are sensory, motor, or proprioceptive in origin. Furthermore, umami is a more unfamiliar and complex taste than other basic tastes. Considering these issues, it may be effective to minimize somatosensory stimuli, oral movement, and psychological effects in a neuroimaging study to elicit cerebral activity by pure umami on the human tongue. For this purpose, we developed an original taste delivery system for functional magnetic resonance imaging (fMRI) studies for umami. Then, we compared the results produced by two authorized models, namely, the block design model and event-related design model, to decide the appropriate model for detecting activation by umami. Activation by the umami taste was well localized in the insular cortex using our new system and block design model analysis. The peaks of the activated areas in the middle insular cortex by umami were very close to another prototypical taste quality (salty). Although we have to carefully interpret the perceiving intensities and brain activations by taste from different sessions, this study design might be effective for detecting the accession area in the cortex of pure umami taste on the tongue. © 2011 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_HK
dc.relation.ispartofBrain Researchen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in <Journal title>. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI#en_US
dc.subject.meshAdulten_HK
dc.subject.meshBrain - blood supply - physiologyen_HK
dc.subject.meshBrain Mappingen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshInosine Monophosphate - administration & dosageen_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNeural Pathways - blood supplyen_HK
dc.subject.meshOxygen - blooden_HK
dc.subject.meshReproducibility of Resultsen_HK
dc.subject.meshSodium Glutamate - administration & dosageen_HK
dc.subject.meshStimulation, Chemicalen_HK
dc.subject.meshTaste - physiologyen_HK
dc.subject.meshTaste Threshold - physiologyen_HK
dc.subject.meshYoung Adulten_HK
dc.titleLocalization of brain activation by umami taste in humansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-8993&volume=1046&spage=18&epage=29&date=2011&atitle=Localization+of+brain+activation+by+umami+taste+in+humansen_US
dc.identifier.emailGoto, TK:gototk@hku.hken_HK
dc.identifier.authorityGoto, TK=rp01434en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.brainres.2011.06.029en_HK
dc.identifier.pmid21762881en_HK
dc.identifier.scopuseid_2-s2.0-79960845610en_HK
dc.identifier.hkuros191407en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960845610&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1406en_HK
dc.identifier.spage18en_HK
dc.identifier.epage29en_HK
dc.identifier.eissn1872-6240-
dc.identifier.isiWOS:000294141600003-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridNakamura, Y=36106137700en_HK
dc.identifier.scopusauthoridGoto, TK=7403938313en_HK
dc.identifier.scopusauthoridTokumori, K=35312507500en_HK
dc.identifier.scopusauthoridYoshiura, T=7003641296en_HK
dc.identifier.scopusauthoridKobayashi, K=24076495200en_HK
dc.identifier.scopusauthoridNakamura, Y=7406387857en_HK
dc.identifier.scopusauthoridHonda, H=36012722500en_HK
dc.identifier.scopusauthoridNinomiya, Y=7201658663en_HK
dc.identifier.scopusauthoridYoshiura, K=7006527913en_HK
dc.identifier.citeulike9488306-

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