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Article: Comparison of gene expression of tissue inhibitor of matrix metalloproteinase-1 between continuous and intermittent distraction osteogenesis: a quantitative study on rabbits
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TitleComparison of gene expression of tissue inhibitor of matrix metalloproteinase-1 between continuous and intermittent distraction osteogenesis: a quantitative study on rabbits
 
AuthorsLiu, X
Cheung, LK1
Zhang, HX1 2
Li, J
Ma, L1
Zheng, L1
 
KeywordsDistraction osteogenesis
Frequency of distraction
Rabbit
Tissue inhibitor of matrix metalloproteinase
Messenger RNA
 
Issue Date2012
 
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcms
 
CitationJournal of Cranio-Maxillofacial Surgery, 2012, v. 40 n. 7, p. e185-e188 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jcms.2011.10.005
 
AbstractBACKGROUND: Distraction osteogenesis is a controlled surgical procedure that initiates a regenerative process and uses mechanical strain to enhance the biological responses of the injured tissues to create new bone. To explore the effect of high-frequency mechanical traction on the expression of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), we compared the gene expression of TIMP-1 between continuous and intermittent distraction osteogenesis using a rabbit model of mandibular lengthening. MATERIALS AND METHODS: Forty adult New Zealand white rabbits were randomly assigned to the intermittent and continuous distraction groups. A unilateral mandibular osteotomy was performed and a custom-designed manual-driven or auto-driven distractor was bridged over the osteotomy segments. Animals were sacrificed at day-6, day-10, day-14 and day-21 after osteotomy. Samples were examined with real-time polymerase chain reaction (PCR). RESULTS: Real-time PCR examination showed significantly higher mRNA levels of TIMP-1 under continuous distraction than that under intermittent distraction at day-6 and day-10. No significant differences were found at day-14 and day-21. CONCLUSION: High-frequency traction provides a good mechanical environment for accelerating bone formation by up-regulating TIMP-1.
 
ISSN1010-5182
2012 Impact Factor: 1.61
2012 SCImago Journal Rankings: 0.828
 
DOIhttp://dx.doi.org/10.1016/j.jcms.2011.10.005
 
DC FieldValue
dc.contributor.authorLiu, X
 
dc.contributor.authorCheung, LK
 
dc.contributor.authorZhang, HX
 
dc.contributor.authorLi, J
 
dc.contributor.authorMa, L
 
dc.contributor.authorZheng, L
 
dc.date.accessioned2011-08-26T14:18:02Z
 
dc.date.available2011-08-26T14:18:02Z
 
dc.date.issued2012
 
dc.description.abstractBACKGROUND: Distraction osteogenesis is a controlled surgical procedure that initiates a regenerative process and uses mechanical strain to enhance the biological responses of the injured tissues to create new bone. To explore the effect of high-frequency mechanical traction on the expression of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), we compared the gene expression of TIMP-1 between continuous and intermittent distraction osteogenesis using a rabbit model of mandibular lengthening. MATERIALS AND METHODS: Forty adult New Zealand white rabbits were randomly assigned to the intermittent and continuous distraction groups. A unilateral mandibular osteotomy was performed and a custom-designed manual-driven or auto-driven distractor was bridged over the osteotomy segments. Animals were sacrificed at day-6, day-10, day-14 and day-21 after osteotomy. Samples were examined with real-time polymerase chain reaction (PCR). RESULTS: Real-time PCR examination showed significantly higher mRNA levels of TIMP-1 under continuous distraction than that under intermittent distraction at day-6 and day-10. No significant differences were found at day-14 and day-21. CONCLUSION: High-frequency traction provides a good mechanical environment for accelerating bone formation by up-regulating TIMP-1.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal of Cranio-Maxillofacial Surgery, 2012, v. 40 n. 7, p. e185-e188 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jcms.2011.10.005
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jcms.2011.10.005
 
dc.identifier.epagee188
 
dc.identifier.hkuros189947
 
dc.identifier.hkuros226148
 
dc.identifier.hkuros204624
 
dc.identifier.issn1010-5182
2012 Impact Factor: 1.61
2012 SCImago Journal Rankings: 0.828
 
dc.identifier.issue7
 
dc.identifier.pmid22093241
 
dc.identifier.scopuseid_2-s2.0-84865790271
 
dc.identifier.spagee185
 
dc.identifier.urihttp://hdl.handle.net/10722/137175
 
dc.identifier.volume40
 
dc.languageeng
 
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcms
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgery
 
dc.subjectDistraction osteogenesis
 
dc.subjectFrequency of distraction
 
dc.subjectRabbit
 
dc.subjectTissue inhibitor of matrix metalloproteinase
 
dc.subjectMessenger RNA
 
dc.titleComparison of gene expression of tissue inhibitor of matrix metalloproteinase-1 between continuous and intermittent distraction osteogenesis: a quantitative study on rabbits
 
dc.typeArticle
 
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<item><contributor.author>Liu, X</contributor.author>
<contributor.author>Cheung, LK</contributor.author>
<contributor.author>Zhang, HX</contributor.author>
<contributor.author>Li, J</contributor.author>
<contributor.author>Ma, L</contributor.author>
<contributor.author>Zheng, L</contributor.author>
<date.accessioned>2011-08-26T14:18:02Z</date.accessioned>
<date.available>2011-08-26T14:18:02Z</date.available>
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<identifier.citation>Journal of Cranio-Maxillofacial Surgery, 2012, v. 40 n. 7, p. e185-e188</identifier.citation>
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<description.abstract>BACKGROUND: Distraction osteogenesis is a controlled surgical procedure that initiates a regenerative process and uses mechanical strain to enhance the biological responses of the injured tissues to create new bone. To explore the effect of high-frequency mechanical traction on the expression of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), we compared the gene expression of TIMP-1 between continuous and intermittent distraction osteogenesis using a rabbit model of mandibular lengthening. MATERIALS AND METHODS: Forty adult New Zealand white rabbits were randomly assigned to the intermittent and continuous distraction groups. A unilateral mandibular osteotomy was performed and a custom-designed manual-driven or auto-driven distractor was bridged over the osteotomy segments. Animals were sacrificed at day-6, day-10, day-14 and day-21 after osteotomy. Samples were examined with real-time polymerase chain reaction (PCR). RESULTS: Real-time PCR examination showed significantly higher mRNA levels of TIMP-1 under continuous distraction than that under intermittent distraction at day-6 and day-10. No significant differences were found at day-14 and day-21. CONCLUSION: High-frequency traction provides a good mechanical environment for accelerating bone formation by up-regulating TIMP-1.</description.abstract>
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<subject>Distraction osteogenesis</subject>
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Author Affiliations
  1. The University of Hong Kong
  2. Wuhan University