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Article: Comparison of gene expression of tissue inhibitor of matrix metalloproteinase-1 between continuous and intermittent distraction osteogenesis: a quantitative study on rabbits

TitleComparison of gene expression of tissue inhibitor of matrix metalloproteinase-1 between continuous and intermittent distraction osteogenesis: a quantitative study on rabbits
Authors
KeywordsDistraction osteogenesis
Frequency of distraction
Rabbit
Tissue inhibitor of matrix metalloproteinase
Messenger RNA
Issue Date2012
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcms
Citation
Journal of Cranio-Maxillofacial Surgery, 2012, v. 40 n. 7, p. e185-e188 How to Cite?
AbstractBACKGROUND: Distraction osteogenesis is a controlled surgical procedure that initiates a regenerative process and uses mechanical strain to enhance the biological responses of the injured tissues to create new bone. To explore the effect of high-frequency mechanical traction on the expression of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), we compared the gene expression of TIMP-1 between continuous and intermittent distraction osteogenesis using a rabbit model of mandibular lengthening. MATERIALS AND METHODS: Forty adult New Zealand white rabbits were randomly assigned to the intermittent and continuous distraction groups. A unilateral mandibular osteotomy was performed and a custom-designed manual-driven or auto-driven distractor was bridged over the osteotomy segments. Animals were sacrificed at day-6, day-10, day-14 and day-21 after osteotomy. Samples were examined with real-time polymerase chain reaction (PCR). RESULTS: Real-time PCR examination showed significantly higher mRNA levels of TIMP-1 under continuous distraction than that under intermittent distraction at day-6 and day-10. No significant differences were found at day-14 and day-21. CONCLUSION: High-frequency traction provides a good mechanical environment for accelerating bone formation by up-regulating TIMP-1.
Persistent Identifierhttp://hdl.handle.net/10722/137175
ISSN
2014 Impact Factor: 2.933
2014 SCImago Journal Rankings: 1.153

 

DC FieldValueLanguage
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorCheung, LKen_HK
dc.contributor.authorZhang, HXen_HK
dc.contributor.authorLi, Jen_HK
dc.contributor.authorMa, Len_HK
dc.contributor.authorZheng, Len_HK
dc.date.accessioned2011-08-26T14:18:02Z-
dc.date.available2011-08-26T14:18:02Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal of Cranio-Maxillofacial Surgery, 2012, v. 40 n. 7, p. e185-e188en_HK
dc.identifier.issn1010-5182en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137175-
dc.description.abstractBACKGROUND: Distraction osteogenesis is a controlled surgical procedure that initiates a regenerative process and uses mechanical strain to enhance the biological responses of the injured tissues to create new bone. To explore the effect of high-frequency mechanical traction on the expression of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), we compared the gene expression of TIMP-1 between continuous and intermittent distraction osteogenesis using a rabbit model of mandibular lengthening. MATERIALS AND METHODS: Forty adult New Zealand white rabbits were randomly assigned to the intermittent and continuous distraction groups. A unilateral mandibular osteotomy was performed and a custom-designed manual-driven or auto-driven distractor was bridged over the osteotomy segments. Animals were sacrificed at day-6, day-10, day-14 and day-21 after osteotomy. Samples were examined with real-time polymerase chain reaction (PCR). RESULTS: Real-time PCR examination showed significantly higher mRNA levels of TIMP-1 under continuous distraction than that under intermittent distraction at day-6 and day-10. No significant differences were found at day-14 and day-21. CONCLUSION: High-frequency traction provides a good mechanical environment for accelerating bone formation by up-regulating TIMP-1.en_HK
dc.languageengen_US
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcmsen_HK
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgeryen_HK
dc.subjectDistraction osteogenesisen_HK
dc.subjectFrequency of distractionen_HK
dc.subjectRabbiten_HK
dc.subjectTissue inhibitor of matrix metalloproteinaseen_HK
dc.subjectMessenger RNA-
dc.titleComparison of gene expression of tissue inhibitor of matrix metalloproteinase-1 between continuous and intermittent distraction osteogenesis: a quantitative study on rabbitsen_HK
dc.typeArticleen_HK
dc.identifier.emailLiu, X: emilylxl@hku.hken_HK
dc.identifier.emailCheung, LK: lkcheung@hkucc.hku.hken_HK
dc.identifier.emailLi, J: jyli@HKUSUC.hku.hk-
dc.identifier.emailMa, L: lima@hku.hk-
dc.identifier.emailZheng, L: lwzheng@hku.hk-
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.identifier.authorityZheng, L=rp01411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jcms.2011.10.005en_HK
dc.identifier.pmid22093241-
dc.identifier.scopuseid_2-s2.0-84865790271en_HK
dc.identifier.hkuros189947en_US
dc.identifier.hkuros226148-
dc.identifier.hkuros204624-
dc.identifier.volume40-
dc.identifier.issue7-
dc.identifier.spagee185-
dc.identifier.epagee188-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLiu, XL=54385553300en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK
dc.identifier.scopusauthoridZhang, HX=15830571700en_HK
dc.identifier.scopusauthoridLi, JY=54385407600en_HK
dc.identifier.scopusauthoridMa, L=36071946000en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK

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