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Article: The kinetochore and cancer: What's the connection?

TitleThe kinetochore and cancer: What's the connection?
Authors
Issue Date2005
PublisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/ceb
Citation
Current Opinion In Cell Biology, 2005, v. 17 n. 6, p. 576-582 How to Cite?
AbstractThe molecular mechanisms ensuring accurate chromosome segregation during meiosis and mitosis are critical to the conservation of euploidy (normal chromosome number) in eukaryotic cells. A dysfunctional kinetochore represents one possible source for chromosome instability (CIN) and the generation of aneuploidy. The kinetochore is a large complex of proteins and associated centromeric DNA that is responsible for mediating the segregation of sister chromatids to daughter cells via its interactions with the mitotic spindle. Continued identification of conserved kinetochore components in model systems such as yeast has provided a rich resource of candidate genes that may be mutated or misregulated in human cancers. Systematic mutational testing and transcriptional profiling of CIN candidate kinetochore genes should shed light on the kinetochore's role in tumorigenesis, and on the general role CIN plays in cancer development. © 2005 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/137035
ISSN
2015 Impact Factor: 8.851
2015 SCImago Journal Rankings: 7.046
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, KWYen_HK
dc.contributor.authorMontpetit, Ben_HK
dc.contributor.authorHieter, Pen_HK
dc.date.accessioned2011-07-29T02:14:46Z-
dc.date.available2011-07-29T02:14:46Z-
dc.date.issued2005en_HK
dc.identifier.citationCurrent Opinion In Cell Biology, 2005, v. 17 n. 6, p. 576-582en_HK
dc.identifier.issn0955-0674en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137035-
dc.description.abstractThe molecular mechanisms ensuring accurate chromosome segregation during meiosis and mitosis are critical to the conservation of euploidy (normal chromosome number) in eukaryotic cells. A dysfunctional kinetochore represents one possible source for chromosome instability (CIN) and the generation of aneuploidy. The kinetochore is a large complex of proteins and associated centromeric DNA that is responsible for mediating the segregation of sister chromatids to daughter cells via its interactions with the mitotic spindle. Continued identification of conserved kinetochore components in model systems such as yeast has provided a rich resource of candidate genes that may be mutated or misregulated in human cancers. Systematic mutational testing and transcriptional profiling of CIN candidate kinetochore genes should shed light on the kinetochore's role in tumorigenesis, and on the general role CIN plays in cancer development. © 2005 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/ceben_HK
dc.relation.ispartofCurrent Opinion in Cell Biologyen_HK
dc.titleThe kinetochore and cancer: What's the connection?en_HK
dc.typeArticleen_HK
dc.identifier.emailYuen, KWY:kwyyuen@hku.hken_US
dc.identifier.authorityYuen, KWY=rp01512en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ceb.2005.09.012en_HK
dc.identifier.pmid16233975-
dc.identifier.scopuseid_2-s2.0-27544434899en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27544434899&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue6en_HK
dc.identifier.spage576en_HK
dc.identifier.epage582en_HK
dc.identifier.isiWOS:000233666300003-
dc.publisher.placeUnited Kingdomen_HK

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