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Article: Systematic genome instability screens in yeast and their potential relevance to cancer

TitleSystematic genome instability screens in yeast and their potential relevance to cancer
Authors
Issue Date2007
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2007, v. 104 n. 10, p. 3925-3930 How to Cite?
Abstract
To systematically identify genes that maintain genome structure, yeast knockout mutants were examined by using three assays that followed marker inheritance in different chromosomal contexts. These screens identified 130 null mutant strains exhibiting chromosome instability (CIN) phenotypes. Differences in both phenotype severity and assay specificity were observed. The results demonstrate the advantages of using complementary assays to comprehensively identify genome maintenance determinants. Genome structure was important in determining the spectrum of gene and pathway mutations causing a chromosome instability phenotype. Protein similarity identified homologues in other species, including human genes with relevance to cancer. This extensive genome instability catalog can be combined with emerging genetic interaction data from yeast to support the identification of candidate targets for therapeutic elimination of chromosomally unstable cancer cells by selective cell killing. © 2007 by The National Academy of Sciences of the USA.
Persistent Identifierhttp://hdl.handle.net/10722/137034
ISSN
2013 Impact Factor: 9.809
PubMed Central ID
ISI Accession Number ID
References

 

Author Affiliations
  1. Michael Smith Laboratories
  2. The University of British Columbia
  3. The Johns Hopkins School of Medicine
DC FieldValueLanguage
dc.contributor.authorYuen, KWYen_HK
dc.contributor.authorWarren, CDen_HK
dc.contributor.authorChen, Oen_HK
dc.contributor.authorKwok, Ten_HK
dc.contributor.authorHieter, Pen_HK
dc.contributor.authorSpencer, FAen_HK
dc.date.accessioned2011-07-29T02:14:46Z-
dc.date.available2011-07-29T02:14:46Z-
dc.date.issued2007en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2007, v. 104 n. 10, p. 3925-3930en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137034-
dc.description.abstractTo systematically identify genes that maintain genome structure, yeast knockout mutants were examined by using three assays that followed marker inheritance in different chromosomal contexts. These screens identified 130 null mutant strains exhibiting chromosome instability (CIN) phenotypes. Differences in both phenotype severity and assay specificity were observed. The results demonstrate the advantages of using complementary assays to comprehensively identify genome maintenance determinants. Genome structure was important in determining the spectrum of gene and pathway mutations causing a chromosome instability phenotype. Protein similarity identified homologues in other species, including human genes with relevance to cancer. This extensive genome instability catalog can be combined with emerging genetic interaction data from yeast to support the identification of candidate targets for therapeutic elimination of chromosomally unstable cancer cells by selective cell killing. © 2007 by The National Academy of Sciences of the USA.en_HK
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.titleSystematic genome instability screens in yeast and their potential relevance to canceren_HK
dc.typeArticleen_HK
dc.identifier.emailYuen, KWY: kwyyuen@hku.hken_HK
dc.identifier.authorityYuen, KWY=rp01512en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1073/pnas.0610642104en_HK
dc.identifier.pmid17360454en_HK
dc.identifier.pmcidPMC1820685-
dc.identifier.scopuseid_2-s2.0-34247200412en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247200412&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume104en_HK
dc.identifier.issue10en_HK
dc.identifier.spage3925en_HK
dc.identifier.epage3930en_HK
dc.identifier.eissn1091-6490-
dc.identifier.isiWOS:000244972400047-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuen, KWY=8841935800en_HK
dc.identifier.scopusauthoridWarren, CD=8060338400en_HK
dc.identifier.scopusauthoridChen, O=16232220800en_HK
dc.identifier.scopusauthoridKwok, T=36954282900en_HK
dc.identifier.scopusauthoridHieter, P=7006930573en_HK
dc.identifier.scopusauthoridSpencer, FA=7102173759en_HK
dc.identifier.citeulike5846274-

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