Article: Systematic genome instability screens in yeast and their potential relevance to cancer

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TitleSystematic genome instability screens in yeast and their potential relevance to cancer
AuthorsYuen, KWY1 2
Warren, CD3
Chen, O3
Kwok, T1 2
Hieter, P1 2
Spencer, FA3
Issue Date2007
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
CitationProceedings Of The National Academy Of Sciences Of The United States Of America, 2007, v. 104 n. 10, p. 3925-3930 [How to Cite?]
DOI: http://dx.doi.org/10.1073/pnas.0610642104
AbstractTo systematically identify genes that maintain genome structure, yeast knockout mutants were examined by using three assays that followed marker inheritance in different chromosomal contexts. These screens identified 130 null mutant strains exhibiting chromosome instability (CIN) phenotypes. Differences in both phenotype severity and assay specificity were observed. The results demonstrate the advantages of using complementary assays to comprehensively identify genome maintenance determinants. Genome structure was important in determining the spectrum of gene and pathway mutations causing a chromosome instability phenotype. Protein similarity identified homologues in other species, including human genes with relevance to cancer. This extensive genome instability catalog can be combined with emerging genetic interaction data from yeast to support the identification of candidate targets for therapeutic elimination of chromosomally unstable cancer cells by selective cell killing. © 2007 by The National Academy of Sciences of the USA.
ISSN0027-8424
2011 Impact Factor: 9.681
2011 SCImago Journal Rankings: 1.754
DOIhttp://dx.doi.org/10.1073/pnas.0610642104
PubMed Central IDPMC1820685
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYuen, KWY
dc.contributor.authorWarren, CD
dc.contributor.authorChen, O
dc.contributor.authorKwok, T
dc.contributor.authorHieter, P
dc.contributor.authorSpencer, FA
dc.date.accessioned2011-07-29T02:14:46Z
dc.date.available2011-07-29T02:14:46Z
dc.date.issued2007
dc.description.abstractTo systematically identify genes that maintain genome structure, yeast knockout mutants were examined by using three assays that followed marker inheritance in different chromosomal contexts. These screens identified 130 null mutant strains exhibiting chromosome instability (CIN) phenotypes. Differences in both phenotype severity and assay specificity were observed. The results demonstrate the advantages of using complementary assays to comprehensively identify genome maintenance determinants. Genome structure was important in determining the spectrum of gene and pathway mutations causing a chromosome instability phenotype. Protein similarity identified homologues in other species, including human genes with relevance to cancer. This extensive genome instability catalog can be combined with emerging genetic interaction data from yeast to support the identification of candidate targets for therapeutic elimination of chromosomally unstable cancer cells by selective cell killing. © 2007 by The National Academy of Sciences of the USA.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2007, v. 104 n. 10, p. 3925-3930 [How to Cite?]
DOI: http://dx.doi.org/10.1073/pnas.0610642104
dc.identifier.citeulike5846274
dc.identifier.doihttp://dx.doi.org/10.1073/pnas.0610642104
dc.identifier.epage3930
dc.identifier.isiWOS:000244972400047
dc.identifier.issn0027-8424
2011 Impact Factor: 9.681
2011 SCImago Journal Rankings: 1.754
dc.identifier.issue10
dc.identifier.pmcidPMC1820685
dc.identifier.pmid17360454
dc.identifier.scopuseid_2-s2.0-34247200412
dc.identifier.spage3925
dc.identifier.urihttp://hdl.handle.net/10722/137034
dc.identifier.volume104
dc.languageeng
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
dc.publisher.placeUnited States
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America
dc.relation.referencesReferences in Scopus
dc.titleSystematic genome instability screens in yeast and their potential relevance to cancer
dc.typeArticle
Author Affiliations
  1. Michael Smith Laboratories
  2. The University of British Columbia
  3. The Johns Hopkins School of Medicine