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Article: Systematic genome instability screens in yeast and their potential relevance to cancer
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TitleSystematic genome instability screens in yeast and their potential relevance to cancer
 
AuthorsYuen, KWY1 2
Warren, CD3
Chen, O3
Kwok, T1 2
Hieter, P1 2
Spencer, FA3 3 3
 
Issue Date2007
 
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
 
CitationProceedings Of The National Academy Of Sciences Of The United States Of America, 2007, v. 104 n. 10, p. 3925-3930 [How to Cite?]
DOI: http://dx.doi.org/10.1073/pnas.0610642104
 
AbstractTo systematically identify genes that maintain genome structure, yeast knockout mutants were examined by using three assays that followed marker inheritance in different chromosomal contexts. These screens identified 130 null mutant strains exhibiting chromosome instability (CIN) phenotypes. Differences in both phenotype severity and assay specificity were observed. The results demonstrate the advantages of using complementary assays to comprehensively identify genome maintenance determinants. Genome structure was important in determining the spectrum of gene and pathway mutations causing a chromosome instability phenotype. Protein similarity identified homologues in other species, including human genes with relevance to cancer. This extensive genome instability catalog can be combined with emerging genetic interaction data from yeast to support the identification of candidate targets for therapeutic elimination of chromosomally unstable cancer cells by selective cell killing. © 2007 by The National Academy of Sciences of the USA.
 
ISSN0027-8424
2012 Impact Factor: 9.737
2012 SCImago Journal Rankings: 5.473
 
DOIhttp://dx.doi.org/10.1073/pnas.0610642104
 
PubMed Central IDPMC1820685
 
ISI Accession Number IDWOS:000244972400047
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYuen, KWY
 
dc.contributor.authorWarren, CD
 
dc.contributor.authorChen, O
 
dc.contributor.authorKwok, T
 
dc.contributor.authorHieter, P
 
dc.contributor.authorSpencer, FA
 
dc.date.accessioned2011-07-29T02:14:46Z
 
dc.date.available2011-07-29T02:14:46Z
 
dc.date.issued2007
 
dc.description.abstractTo systematically identify genes that maintain genome structure, yeast knockout mutants were examined by using three assays that followed marker inheritance in different chromosomal contexts. These screens identified 130 null mutant strains exhibiting chromosome instability (CIN) phenotypes. Differences in both phenotype severity and assay specificity were observed. The results demonstrate the advantages of using complementary assays to comprehensively identify genome maintenance determinants. Genome structure was important in determining the spectrum of gene and pathway mutations causing a chromosome instability phenotype. Protein similarity identified homologues in other species, including human genes with relevance to cancer. This extensive genome instability catalog can be combined with emerging genetic interaction data from yeast to support the identification of candidate targets for therapeutic elimination of chromosomally unstable cancer cells by selective cell killing. © 2007 by The National Academy of Sciences of the USA.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2007, v. 104 n. 10, p. 3925-3930 [How to Cite?]
DOI: http://dx.doi.org/10.1073/pnas.0610642104
 
dc.identifier.citeulike5846274
 
dc.identifier.doihttp://dx.doi.org/10.1073/pnas.0610642104
 
dc.identifier.eissn1091-6490
 
dc.identifier.epage3930
 
dc.identifier.isiWOS:000244972400047
 
dc.identifier.issn0027-8424
2012 Impact Factor: 9.737
2012 SCImago Journal Rankings: 5.473
 
dc.identifier.issue10
 
dc.identifier.pmcidPMC1820685
 
dc.identifier.pmid17360454
 
dc.identifier.scopuseid_2-s2.0-34247200412
 
dc.identifier.spage3925
 
dc.identifier.urihttp://hdl.handle.net/10722/137034
 
dc.identifier.volume104
 
dc.languageeng
 
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America
 
dc.relation.referencesReferences in Scopus
 
dc.titleSystematic genome instability screens in yeast and their potential relevance to cancer
 
dc.typeArticle
 
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Author Affiliations
  1. Michael Smith Laboratories
  2. The University of British Columbia
  3. The Johns Hopkins School of Medicine