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Article: Vitamin E supplementation improves cell-mediated immunity and oxidative stress of asian men and women

TitleVitamin E supplementation improves cell-mediated immunity and oxidative stress of asian men and women
Authors
KeywordsFree radicals
Humans
Immunity
Oxidative stress
Vitamin E
Issue Date2000
PublisherAmerican Society for Nutrition. The Journal's web site is located at http://jn.nutrition.org
Citation
Journal Of Nutrition, 2000, v. 130 n. 12, p. 2932-2937 How to Cite?
AbstractVitamin E is an efficient antioxidant and a modulator of the immune system. Although racial differences in both baseline vitamin E level and immunologic subsets are known, no reliable data exist for the Asian population. Furthermore, the extent of the effect of α-tocopherol in protecting lymphocyte cells against oxidative stress and its association with cell-mediated immunity have not been elucidated. This study was undertaken to investigate the immunologic and antioxidant effects of vitamin E in healthy ethnic Chinese men and women. Volunteers < 35 y old (n = 26) were supplemented with 233 mg/d dl-α-tocopherol for 28 d. The in vitro proliferative response to phytohemagglutinin (PHA) or lipopolysaccharide (LPS) of T-lymphocytes was determined in the study group before and after vitamin E supplementation. Cell-mediated immunity subsets and hydrogen peroxide production in T-lymphocytes were investigated by flow cytometry. The oxidant-antioxidant balance in plasma and urine was studied by spectrophotometric and gas chromatography-mass selective detection methods. The antioxidant properties of vitamin E were established (P < 0.01) by the elevation of plasma vitamin E, together with depression in both plasma malondialdehyde and urinary DNA adduct 8-hydroxy-2'-deoxyguanosine after supplementation. Our data suggest a specific requirement for vitamin E in total-T and T-helper cell proliferation. We present the first evidence of the beneficial effects of supplemental vitamin E in healthy Chinese individuals on cell-mediated immunity and oxidative stress.
Persistent Identifierhttp://hdl.handle.net/10722/137032
ISSN
2015 Impact Factor: 3.74
2015 SCImago Journal Rankings: 2.040
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, CYJen_HK
dc.contributor.authorWan, JMFen_HK
dc.date.accessioned2011-07-29T02:14:44Z-
dc.date.available2011-07-29T02:14:44Z-
dc.date.issued2000en_HK
dc.identifier.citationJournal Of Nutrition, 2000, v. 130 n. 12, p. 2932-2937en_HK
dc.identifier.issn0022-3166en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137032-
dc.description.abstractVitamin E is an efficient antioxidant and a modulator of the immune system. Although racial differences in both baseline vitamin E level and immunologic subsets are known, no reliable data exist for the Asian population. Furthermore, the extent of the effect of α-tocopherol in protecting lymphocyte cells against oxidative stress and its association with cell-mediated immunity have not been elucidated. This study was undertaken to investigate the immunologic and antioxidant effects of vitamin E in healthy ethnic Chinese men and women. Volunteers < 35 y old (n = 26) were supplemented with 233 mg/d dl-α-tocopherol for 28 d. The in vitro proliferative response to phytohemagglutinin (PHA) or lipopolysaccharide (LPS) of T-lymphocytes was determined in the study group before and after vitamin E supplementation. Cell-mediated immunity subsets and hydrogen peroxide production in T-lymphocytes were investigated by flow cytometry. The oxidant-antioxidant balance in plasma and urine was studied by spectrophotometric and gas chromatography-mass selective detection methods. The antioxidant properties of vitamin E were established (P < 0.01) by the elevation of plasma vitamin E, together with depression in both plasma malondialdehyde and urinary DNA adduct 8-hydroxy-2'-deoxyguanosine after supplementation. Our data suggest a specific requirement for vitamin E in total-T and T-helper cell proliferation. We present the first evidence of the beneficial effects of supplemental vitamin E in healthy Chinese individuals on cell-mediated immunity and oxidative stress.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Nutrition. The Journal's web site is located at http://jn.nutrition.orgen_HK
dc.relation.ispartofJournal of Nutritionen_HK
dc.subjectFree radicalsen_HK
dc.subjectHumansen_HK
dc.subjectImmunityen_HK
dc.subjectOxidative stressen_HK
dc.subjectVitamin Een_HK
dc.titleVitamin E supplementation improves cell-mediated immunity and oxidative stress of asian men and womenen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, CYJ: jettylee@hku.hken_HK
dc.identifier.emailWan, JMF: jmfwan@hku.hken_HK
dc.identifier.authorityLee, CYJ=rp01511en_HK
dc.identifier.authorityWan, JMF=rp00798en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11110849-
dc.identifier.scopuseid_2-s2.0-0034530058en_HK
dc.identifier.hkuros61098-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034530058&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume130en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2932en_HK
dc.identifier.epage2937en_HK
dc.identifier.isiWOS:000165866200012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLee, CYJ=13104265200en_HK
dc.identifier.scopusauthoridWan, JMF=8930305000en_HK

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