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- PMID: 11110849
- WOS: WOS:000165866200012
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Article: Vitamin E supplementation improves cell-mediated immunity and oxidative stress of asian men and women
Title | Vitamin E supplementation improves cell-mediated immunity and oxidative stress of asian men and women |
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Authors | |
Keywords | Free radicals Humans Immunity Oxidative stress Vitamin E |
Issue Date | 2000 |
Publisher | American Society for Nutrition. The Journal's web site is located at http://jn.nutrition.org |
Citation | Journal Of Nutrition, 2000, v. 130 n. 12, p. 2932-2937 How to Cite? |
Abstract | Vitamin E is an efficient antioxidant and a modulator of the immune system. Although racial differences in both baseline vitamin E level and immunologic subsets are known, no reliable data exist for the Asian population. Furthermore, the extent of the effect of α-tocopherol in protecting lymphocyte cells against oxidative stress and its association with cell-mediated immunity have not been elucidated. This study was undertaken to investigate the immunologic and antioxidant effects of vitamin E in healthy ethnic Chinese men and women. Volunteers < 35 y old (n = 26) were supplemented with 233 mg/d dl-α-tocopherol for 28 d. The in vitro proliferative response to phytohemagglutinin (PHA) or lipopolysaccharide (LPS) of T-lymphocytes was determined in the study group before and after vitamin E supplementation. Cell-mediated immunity subsets and hydrogen peroxide production in T-lymphocytes were investigated by flow cytometry. The oxidant-antioxidant balance in plasma and urine was studied by spectrophotometric and gas chromatography-mass selective detection methods. The antioxidant properties of vitamin E were established (P < 0.01) by the elevation of plasma vitamin E, together with depression in both plasma malondialdehyde and urinary DNA adduct 8-hydroxy-2'-deoxyguanosine after supplementation. Our data suggest a specific requirement for vitamin E in total-T and T-helper cell proliferation. We present the first evidence of the beneficial effects of supplemental vitamin E in healthy Chinese individuals on cell-mediated immunity and oxidative stress. |
Persistent Identifier | http://hdl.handle.net/10722/137032 |
ISSN | 2021 Impact Factor: 4.687 2020 SCImago Journal Rankings: 1.463 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, CYJ | en_HK |
dc.contributor.author | Wan, JMF | en_HK |
dc.date.accessioned | 2011-07-29T02:14:44Z | - |
dc.date.available | 2011-07-29T02:14:44Z | - |
dc.date.issued | 2000 | en_HK |
dc.identifier.citation | Journal Of Nutrition, 2000, v. 130 n. 12, p. 2932-2937 | en_HK |
dc.identifier.issn | 0022-3166 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/137032 | - |
dc.description.abstract | Vitamin E is an efficient antioxidant and a modulator of the immune system. Although racial differences in both baseline vitamin E level and immunologic subsets are known, no reliable data exist for the Asian population. Furthermore, the extent of the effect of α-tocopherol in protecting lymphocyte cells against oxidative stress and its association with cell-mediated immunity have not been elucidated. This study was undertaken to investigate the immunologic and antioxidant effects of vitamin E in healthy ethnic Chinese men and women. Volunteers < 35 y old (n = 26) were supplemented with 233 mg/d dl-α-tocopherol for 28 d. The in vitro proliferative response to phytohemagglutinin (PHA) or lipopolysaccharide (LPS) of T-lymphocytes was determined in the study group before and after vitamin E supplementation. Cell-mediated immunity subsets and hydrogen peroxide production in T-lymphocytes were investigated by flow cytometry. The oxidant-antioxidant balance in plasma and urine was studied by spectrophotometric and gas chromatography-mass selective detection methods. The antioxidant properties of vitamin E were established (P < 0.01) by the elevation of plasma vitamin E, together with depression in both plasma malondialdehyde and urinary DNA adduct 8-hydroxy-2'-deoxyguanosine after supplementation. Our data suggest a specific requirement for vitamin E in total-T and T-helper cell proliferation. We present the first evidence of the beneficial effects of supplemental vitamin E in healthy Chinese individuals on cell-mediated immunity and oxidative stress. | en_HK |
dc.language | eng | en_US |
dc.publisher | American Society for Nutrition. The Journal's web site is located at http://jn.nutrition.org | en_HK |
dc.relation.ispartof | Journal of Nutrition | en_HK |
dc.subject | Free radicals | en_HK |
dc.subject | Humans | en_HK |
dc.subject | Immunity | en_HK |
dc.subject | Oxidative stress | en_HK |
dc.subject | Vitamin E | en_HK |
dc.title | Vitamin E supplementation improves cell-mediated immunity and oxidative stress of asian men and women | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lee, CYJ: jettylee@hku.hk | en_HK |
dc.identifier.email | Wan, JMF: jmfwan@hku.hk | en_HK |
dc.identifier.authority | Lee, CYJ=rp01511 | en_HK |
dc.identifier.authority | Wan, JMF=rp00798 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 11110849 | - |
dc.identifier.scopus | eid_2-s2.0-0034530058 | en_HK |
dc.identifier.hkuros | 61098 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034530058&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 130 | en_HK |
dc.identifier.issue | 12 | en_HK |
dc.identifier.spage | 2932 | en_HK |
dc.identifier.epage | 2937 | en_HK |
dc.identifier.isi | WOS:000165866200012 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Lee, CYJ=13104265200 | en_HK |
dc.identifier.scopusauthorid | Wan, JMF=8930305000 | en_HK |
dc.identifier.issnl | 0022-3166 | - |