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Article: Protein kinase TTK interacts and co-localizes with CENP-E to the kinetochore of human cells

TitleProtein kinase TTK interacts and co-localizes with CENP-E to the kinetochore of human cells
Authors
KeywordsCENP-E
Kinetochore
Spindle checkpoint
TTK protein kinase
Issue Date2002
PublisherScience China Press. The Journal's web site is located at http://www.springerlink.com/content/1001-6538/
Citation
Chinese Science Bulletin, 2002, v. 47 n. 23, p. 2005-2009 How to Cite?
AbstractSpindle checkpoint is an important biochemical signaling cascade during mitosis which monitors the fidelity of chromosome segregation, and is mediated by protein kinases Mps1 and Bub1/BubR1. Our recent studies show that kinesin-related motor protein CENP-E interacts with BubR1 and participates in spindle checkpoint signaling. To elucidate the molecular mechanisms underlying spindle checkpoint signaling, we carried out proteomic dissection of human cell kinetochore and revealed protein kinase TTK, human homologue of yeast Mps1. Our studies show that TTK is localized to the kinetochore of human cells, and interacts with CENP-E, suggesting that TTK may play an important role in chromosome segregation during mitosis.
Persistent Identifierhttp://hdl.handle.net/10722/136786
ISSN
2015 Impact Factor: 1.789
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorFu, Cen_HK
dc.contributor.authorMiao, Yen_HK
dc.contributor.authorDou, Zen_HK
dc.contributor.authorYao, Xen_HK
dc.date.accessioned2011-07-29T02:12:13Z-
dc.date.available2011-07-29T02:12:13Z-
dc.date.issued2002en_HK
dc.identifier.citationChinese Science Bulletin, 2002, v. 47 n. 23, p. 2005-2009en_HK
dc.identifier.issn1001-6538en_HK
dc.identifier.urihttp://hdl.handle.net/10722/136786-
dc.description.abstractSpindle checkpoint is an important biochemical signaling cascade during mitosis which monitors the fidelity of chromosome segregation, and is mediated by protein kinases Mps1 and Bub1/BubR1. Our recent studies show that kinesin-related motor protein CENP-E interacts with BubR1 and participates in spindle checkpoint signaling. To elucidate the molecular mechanisms underlying spindle checkpoint signaling, we carried out proteomic dissection of human cell kinetochore and revealed protein kinase TTK, human homologue of yeast Mps1. Our studies show that TTK is localized to the kinetochore of human cells, and interacts with CENP-E, suggesting that TTK may play an important role in chromosome segregation during mitosis.en_HK
dc.languageengen_US
dc.publisherScience China Press. The Journal's web site is located at http://www.springerlink.com/content/1001-6538/en_HK
dc.relation.ispartofChinese Science Bulletinen_HK
dc.subjectCENP-Een_HK
dc.subjectKinetochoreen_HK
dc.subjectSpindle checkpointen_HK
dc.subjectTTK protein kinaseen_HK
dc.titleProtein kinase TTK interacts and co-localizes with CENP-E to the kinetochore of human cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailFu, C:chuanhai@hku.hken_HK
dc.identifier.authorityFu, C=rp01515en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1360/02tb9435en_HK
dc.identifier.scopuseid_2-s2.0-4143065560en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4143065560&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue23en_HK
dc.identifier.spage2005en_HK
dc.identifier.epage2009en_HK
dc.identifier.isiWOS:000179588600014-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridZhang, J=36066837600en_HK
dc.identifier.scopusauthoridFu, C=8583808400en_HK
dc.identifier.scopusauthoridMiao, Y=8726267000en_HK
dc.identifier.scopusauthoridDou, Z=7007006881en_HK
dc.identifier.scopusauthoridYao, X=7402530401en_HK

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