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Article: A novel genome-wide full-length kinesin prediction analysis reveals additional mammalian kinesins

TitleA novel genome-wide full-length kinesin prediction analysis reveals additional mammalian kinesins
Authors
KeywordsCENP-E
Comparative genomics
FKPP
Full-length kinesin prediction program
Kinesin
Issue Date2006
Citation
Handbook Of Environmental Chemistry, Volume 5: Water Pollution, 2006, v. 51 n. 15, p. 1836-1847 How to Cite?
AbstractKinesin superfamily of microtubule-based motor orchestrates a variety of cellular processes. Recent availability of mammalian genomes has enabled analyses of kinesins on the whole genome. Here we present a novel full-length kinesin prediction program (FKPP) for mammalian kinesin gene discovery based on a comparative genomics approach. Contrary to previous predictions of 94 kinesins, we identify a total of 134 potentially kinesin genes from mammalian genomes, including 45 from mouse, 45 from rat and 44 from human. In addition, FKPP synthesizes 25 potentially full-length mammalian kinesins based on the partial sequences in the database. Surprisingly, FKPP reveals that full-length human CENP-E contains 2701 aa rather than 2663 aa in the database. Experimentation using sequence specific antibody and cDNA sequencing of human CENP-E validates the accuracy of FKPP. Given the remarkable computing efficiency and accuracy of FKPP, we reclassify the mammalian kinesin superfamily. Since current databases contain many incomplete sequences, FKPP may provide a novel approach for molecular delineation of kinesins and other protein families. © 2006 Science in China Press.
Persistent Identifierhttp://hdl.handle.net/10722/136780
ISSN
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXue, Yen_HK
dc.contributor.authorLiu, Den_HK
dc.contributor.authorFu, Cen_HK
dc.contributor.authorDou, Zen_HK
dc.contributor.authorZhou, Qen_HK
dc.contributor.authorYao, Xen_HK
dc.date.accessioned2011-07-29T02:12:08Z-
dc.date.available2011-07-29T02:12:08Z-
dc.date.issued2006en_HK
dc.identifier.citationHandbook Of Environmental Chemistry, Volume 5: Water Pollution, 2006, v. 51 n. 15, p. 1836-1847en_HK
dc.identifier.issn1433-6863en_HK
dc.identifier.urihttp://hdl.handle.net/10722/136780-
dc.description.abstractKinesin superfamily of microtubule-based motor orchestrates a variety of cellular processes. Recent availability of mammalian genomes has enabled analyses of kinesins on the whole genome. Here we present a novel full-length kinesin prediction program (FKPP) for mammalian kinesin gene discovery based on a comparative genomics approach. Contrary to previous predictions of 94 kinesins, we identify a total of 134 potentially kinesin genes from mammalian genomes, including 45 from mouse, 45 from rat and 44 from human. In addition, FKPP synthesizes 25 potentially full-length mammalian kinesins based on the partial sequences in the database. Surprisingly, FKPP reveals that full-length human CENP-E contains 2701 aa rather than 2663 aa in the database. Experimentation using sequence specific antibody and cDNA sequencing of human CENP-E validates the accuracy of FKPP. Given the remarkable computing efficiency and accuracy of FKPP, we reclassify the mammalian kinesin superfamily. Since current databases contain many incomplete sequences, FKPP may provide a novel approach for molecular delineation of kinesins and other protein families. © 2006 Science in China Press.en_HK
dc.languageengen_US
dc.relation.ispartofHandbook of Environmental Chemistry, Volume 5: Water Pollutionen_HK
dc.subjectCENP-Een_HK
dc.subjectComparative genomicsen_HK
dc.subjectFKPPen_HK
dc.subjectFull-length kinesin prediction programen_HK
dc.subjectKinesinen_HK
dc.titleA novel genome-wide full-length kinesin prediction analysis reveals additional mammalian kinesinsen_HK
dc.typeArticleen_HK
dc.identifier.emailFu, C:chuanhai@hku.hken_HK
dc.identifier.authorityFu, C=rp01515en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s11434-006-2054-8en_HK
dc.identifier.scopuseid_2-s2.0-33947308715en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33947308715&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume51en_HK
dc.identifier.issue15en_HK
dc.identifier.spage1836en_HK
dc.identifier.epage1847en_HK
dc.identifier.eissn1861-9541-
dc.identifier.isiWOS:000240864400007-
dc.identifier.scopusauthoridXue, Y=7402270422en_HK
dc.identifier.scopusauthoridLiu, D=14121530200en_HK
dc.identifier.scopusauthoridFu, C=8583808400en_HK
dc.identifier.scopusauthoridDou, Z=7007006881en_HK
dc.identifier.scopusauthoridZhou, Q=55182803300en_HK
dc.identifier.scopusauthoridYao, X=7402530401en_HK

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