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Conference Paper: The role of proheparanase in synaptic plasticity at the hippocampus

TitleThe role of proheparanase in synaptic plasticity at the hippocampus
Authors
Issue Date2011
Citation
The 9th Biennial Conference of the Chinese Neuroscience Society (CNS 2011) and The 5th Member Congress, Zhengzhou, China, 29 July-1 August 2011. How to Cite?
AbstractPerineuronal heparan sulfate (HS) moieties are implicated in the modulation of neurotransmission by controlling the functional properties of AMPA-type glutamate receptors. We hypothesize that neuronal mechanisms modulate peri-synaptic HS level, thereby regulating synaptic strength and plasticity. To address this, basal synaptic strength and long-term changes in synaptic efficacy in the Schaffer collateral pathway of the rat hippocampus were assessed in relation to strategies that perturb peri-synaptic HS. In hippocampal slices, heparitinase treatment led to dose-dependent attenuation of long-term potentiation (LTP) in correlation with loss of perineuronal HS …
DescriptionAbstract no. P-110
Persistent Identifierhttp://hdl.handle.net/10722/136413

 

DC FieldValueLanguage
dc.contributor.authorMa, CWen_US
dc.contributor.authorCham, WCen_US
dc.contributor.authorLai, CHen_US
dc.contributor.authorShum, DKYen_US
dc.contributor.authorChan, YSen_US
dc.date.accessioned2011-07-27T02:15:36Z-
dc.date.available2011-07-27T02:15:36Z-
dc.date.issued2011en_US
dc.identifier.citationThe 9th Biennial Conference of the Chinese Neuroscience Society (CNS 2011) and The 5th Member Congress, Zhengzhou, China, 29 July-1 August 2011.en_US
dc.identifier.urihttp://hdl.handle.net/10722/136413-
dc.descriptionAbstract no. P-110-
dc.description.abstractPerineuronal heparan sulfate (HS) moieties are implicated in the modulation of neurotransmission by controlling the functional properties of AMPA-type glutamate receptors. We hypothesize that neuronal mechanisms modulate peri-synaptic HS level, thereby regulating synaptic strength and plasticity. To address this, basal synaptic strength and long-term changes in synaptic efficacy in the Schaffer collateral pathway of the rat hippocampus were assessed in relation to strategies that perturb peri-synaptic HS. In hippocampal slices, heparitinase treatment led to dose-dependent attenuation of long-term potentiation (LTP) in correlation with loss of perineuronal HS …-
dc.languageengen_US
dc.relation.ispartof9th CNS Biennial Conference and the 5th Member Congress 2011en_US
dc.relation.ispartof2011年中国神经科学学会第九届全国学术会议暨第五次会员代表大会-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleThe role of proheparanase in synaptic plasticity at the hippocampusen_US
dc.typeConference_Paperen_US
dc.identifier.emailMa, CW: cwma2010@hku.hken_US
dc.identifier.emailCham, WC: chamwc@hku.hken_US
dc.identifier.emailLai, CH: chlaib@hku.hken_US
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_US
dc.identifier.emailChan, YS: yschan@hku.hken_US
dc.identifier.authorityLai, CH=rp00396en_US
dc.identifier.authorityShum, DKY=rp00321en_US
dc.description.naturepostprint-
dc.identifier.hkuros187664en_US

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