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Article: Effects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: A mini-review
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TitleEffects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: A mini-review
 
AuthorsLee, DCW2
Lau, ASY2 1
 
KeywordsCytokines
Ginsenosides
Immunomodulation
Inflammation
Panax ginseng
 
Issue Date2011
 
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/molecules
 
CitationMolecules, 2011, v. 16 n. 4, p. 2802-2816 [How to Cite?]
DOI: http://dx.doi.org/10.3390/molecules16042802
 
AbstractPanax ginseng is one of the most commonly used Chinese medicines in China, Asia and Western countries. The beneficial effects of ginseng have been attributed to the biological activities of its constituents, the ginsenosides. In this review, we summarize recent publications on the anti-inflammatory effects of ginseng extracts and ginsenosides on cellular responses triggered by different inducers including endotoxin, tumor necrosis factor-alpha (TNF-α), interferon-gamma and other stimuli. Proinflammatory cytokines, chemokines, adhesion molecules and mediators of inflammation including inducible nitric oxide synthase, cyclooxygenase-2 and nitric oxide orchestrate the inflammatory response. Ginseng extracts and ginsenosides including Rb 1, Rd, Rg 1, Rg 3, Rh 1, Rh 2, Rh 3 and Rp 1 have been reported to have anti-inflammatory properties in different studies related to inflammation. Ginsenosides inhibit different inducers-activated signaling protein kinases and transcription factor nuclear factor-kappaB leading to decreases in the production of cytokines and mediators of inflammation. The therapeutic potential of ginseng on TNF-α-mediated inflammatory diseases is also discussed. Taken together, this summary provides evidences for the anti-inflammatory effects of ginseng extracts and ginsenosides as well as the underlying mechanisms of their effects on inflammatory diseases. © 2011 by the authors.
 
ISSN1420-3049
2012 Impact Factor: 2.428
2012 SCImago Journal Rankings: 0.692
 
DOIhttp://dx.doi.org/10.3390/molecules16042802
 
ISI Accession Number IDWOS:000289236200006
Funding AgencyGrant Number
SK Lau and William Au Research Fund
Francis SK Lau Research Fund, HKU
Funding Information:

The project was supported in part by SK Lau and William Au Research Fund awarded to Allan Lau for performing Molecular Chinese Medicine studies. We also thank Stanley CC Chik for his expertise in performing the experiments in our published work. The Molecular Chinese Medicine program is supported by Francis SK Lau Research Fund, HKU.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLee, DCW
 
dc.contributor.authorLau, ASY
 
dc.date.accessioned2011-07-27T02:12:53Z
 
dc.date.available2011-07-27T02:12:53Z
 
dc.date.issued2011
 
dc.description.abstractPanax ginseng is one of the most commonly used Chinese medicines in China, Asia and Western countries. The beneficial effects of ginseng have been attributed to the biological activities of its constituents, the ginsenosides. In this review, we summarize recent publications on the anti-inflammatory effects of ginseng extracts and ginsenosides on cellular responses triggered by different inducers including endotoxin, tumor necrosis factor-alpha (TNF-α), interferon-gamma and other stimuli. Proinflammatory cytokines, chemokines, adhesion molecules and mediators of inflammation including inducible nitric oxide synthase, cyclooxygenase-2 and nitric oxide orchestrate the inflammatory response. Ginseng extracts and ginsenosides including Rb 1, Rd, Rg 1, Rg 3, Rh 1, Rh 2, Rh 3 and Rp 1 have been reported to have anti-inflammatory properties in different studies related to inflammation. Ginsenosides inhibit different inducers-activated signaling protein kinases and transcription factor nuclear factor-kappaB leading to decreases in the production of cytokines and mediators of inflammation. The therapeutic potential of ginseng on TNF-α-mediated inflammatory diseases is also discussed. Taken together, this summary provides evidences for the anti-inflammatory effects of ginseng extracts and ginsenosides as well as the underlying mechanisms of their effects on inflammatory diseases. © 2011 by the authors.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationMolecules, 2011, v. 16 n. 4, p. 2802-2816 [How to Cite?]
DOI: http://dx.doi.org/10.3390/molecules16042802
 
dc.identifier.citeulike9479375
 
dc.identifier.doihttp://dx.doi.org/10.3390/molecules16042802
 
dc.identifier.epage2816
 
dc.identifier.hkuros187952
 
dc.identifier.isiWOS:000289236200006
Funding AgencyGrant Number
SK Lau and William Au Research Fund
Francis SK Lau Research Fund, HKU
Funding Information:

The project was supported in part by SK Lau and William Au Research Fund awarded to Allan Lau for performing Molecular Chinese Medicine studies. We also thank Stanley CC Chik for his expertise in performing the experiments in our published work. The Molecular Chinese Medicine program is supported by Francis SK Lau Research Fund, HKU.

 
dc.identifier.issn1420-3049
2012 Impact Factor: 2.428
2012 SCImago Journal Rankings: 0.692
 
dc.identifier.issue4
 
dc.identifier.pmid21455094
 
dc.identifier.scopuseid_2-s2.0-79955545463
 
dc.identifier.spage2802
 
dc.identifier.urihttp://hdl.handle.net/10722/136305
 
dc.identifier.volume16
 
dc.languageeng
 
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/molecules
 
dc.publisher.placeSwitzerland
 
dc.relation.ispartofMolecules
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshCell Line
 
dc.subject.meshInflammation - prevention and control
 
dc.subject.meshPanax - chemistry
 
dc.subject.meshPlant Extracts - therapeutic use
 
dc.subject.meshTumor Necrosis Factor-alpha - physiology
 
dc.subjectCytokines
 
dc.subjectGinsenosides
 
dc.subjectImmunomodulation
 
dc.subjectInflammation
 
dc.subjectPanax ginseng
 
dc.titleEffects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: A mini-review
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong