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Article: Effects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: A mini-review

TitleEffects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: A mini-review
Authors
KeywordsCytokines
Ginsenosides
Immunomodulation
Inflammation
Panax ginseng
Issue Date2011
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/molecules
Citation
Molecules, 2011, v. 16 n. 4, p. 2802-2816 How to Cite?
Abstract
Panax ginseng is one of the most commonly used Chinese medicines in China, Asia and Western countries. The beneficial effects of ginseng have been attributed to the biological activities of its constituents, the ginsenosides. In this review, we summarize recent publications on the anti-inflammatory effects of ginseng extracts and ginsenosides on cellular responses triggered by different inducers including endotoxin, tumor necrosis factor-alpha (TNF-α), interferon-gamma and other stimuli. Proinflammatory cytokines, chemokines, adhesion molecules and mediators of inflammation including inducible nitric oxide synthase, cyclooxygenase-2 and nitric oxide orchestrate the inflammatory response. Ginseng extracts and ginsenosides including Rb 1, Rd, Rg 1, Rg 3, Rh 1, Rh 2, Rh 3 and Rp 1 have been reported to have anti-inflammatory properties in different studies related to inflammation. Ginsenosides inhibit different inducers-activated signaling protein kinases and transcription factor nuclear factor-kappaB leading to decreases in the production of cytokines and mediators of inflammation. The therapeutic potential of ginseng on TNF-α-mediated inflammatory diseases is also discussed. Taken together, this summary provides evidences for the anti-inflammatory effects of ginseng extracts and ginsenosides as well as the underlying mechanisms of their effects on inflammatory diseases. © 2011 by the authors.
Persistent Identifierhttp://hdl.handle.net/10722/136305
ISSN
2013 Impact Factor: 2.095
2013 SCImago Journal Rankings: 0.716
ISI Accession Number ID
Funding AgencyGrant Number
SK Lau and William Au Research Fund
Francis SK Lau Research Fund, HKU
Funding Information:

The project was supported in part by SK Lau and William Au Research Fund awarded to Allan Lau for performing Molecular Chinese Medicine studies. We also thank Stanley CC Chik for his expertise in performing the experiments in our published work. The Molecular Chinese Medicine program is supported by Francis SK Lau Research Fund, HKU.

References

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorLee, DCWen_HK
dc.contributor.authorLau, ASYen_HK
dc.date.accessioned2011-07-27T02:12:53Z-
dc.date.available2011-07-27T02:12:53Z-
dc.date.issued2011en_HK
dc.identifier.citationMolecules, 2011, v. 16 n. 4, p. 2802-2816en_HK
dc.identifier.issn1420-3049en_HK
dc.identifier.urihttp://hdl.handle.net/10722/136305-
dc.description.abstractPanax ginseng is one of the most commonly used Chinese medicines in China, Asia and Western countries. The beneficial effects of ginseng have been attributed to the biological activities of its constituents, the ginsenosides. In this review, we summarize recent publications on the anti-inflammatory effects of ginseng extracts and ginsenosides on cellular responses triggered by different inducers including endotoxin, tumor necrosis factor-alpha (TNF-α), interferon-gamma and other stimuli. Proinflammatory cytokines, chemokines, adhesion molecules and mediators of inflammation including inducible nitric oxide synthase, cyclooxygenase-2 and nitric oxide orchestrate the inflammatory response. Ginseng extracts and ginsenosides including Rb 1, Rd, Rg 1, Rg 3, Rh 1, Rh 2, Rh 3 and Rp 1 have been reported to have anti-inflammatory properties in different studies related to inflammation. Ginsenosides inhibit different inducers-activated signaling protein kinases and transcription factor nuclear factor-kappaB leading to decreases in the production of cytokines and mediators of inflammation. The therapeutic potential of ginseng on TNF-α-mediated inflammatory diseases is also discussed. Taken together, this summary provides evidences for the anti-inflammatory effects of ginseng extracts and ginsenosides as well as the underlying mechanisms of their effects on inflammatory diseases. © 2011 by the authors.en_HK
dc.languageengen_US
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/moleculesen_HK
dc.relation.ispartofMoleculesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCytokinesen_HK
dc.subjectGinsenosidesen_HK
dc.subjectImmunomodulationen_HK
dc.subjectInflammationen_HK
dc.subjectPanax ginsengen_HK
dc.subject.meshCell Line-
dc.subject.meshInflammation - prevention and control-
dc.subject.meshPanax - chemistry-
dc.subject.meshPlant Extracts - therapeutic use-
dc.subject.meshTumor Necrosis Factor-alpha - physiology-
dc.titleEffects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: A mini-reviewen_HK
dc.typeArticleen_HK
dc.identifier.emailLau, ASY:asylau@hku.hken_HK
dc.identifier.authorityLau, ASY=rp00474en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/molecules16042802en_HK
dc.identifier.pmid21455094en_HK
dc.identifier.scopuseid_2-s2.0-79955545463en_HK
dc.identifier.hkuros187952en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955545463&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue4en_HK
dc.identifier.spage2802en_HK
dc.identifier.epage2816en_HK
dc.identifier.isiWOS:000289236200006-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLee, DCW=45961310100en_HK
dc.identifier.scopusauthoridLau, ASY=7202626202en_HK
dc.identifier.citeulike9479375-

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