Article: Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells

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TitleRegulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells
AuthorsWu, H2
Lin, Y2
Li, W2
Sun, Z2
Gao, W2
Zhang, H2
Xie, L2
Jiang, F2
Qin, B2
Yan, T2
Chen, L2
Zhao, Y2
Cao, X1
Wu, Y1
Lin, B1
Zhou, H1
Wong, AST3
Zhang, XK1 2
Zeng, JZ2
KeywordsAP-1
Bile acid
JNK
PI3K
Issue Date2011
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
CitationFaseb Journal, 2011, v. 25 n. 1, p. 192-205 [How to Cite?]
DOI: http://dx.doi.org/10.1096/fj.10-166462
AbstractThe orphan nuclear receptor Nur77 is an immediate-early response gene whose expression is rapidly induced by various extracellular stimuli. The aims of this study were to study the role of Nur77 expression in the growth and survival of colon cancer cells and the mechanism by which Nur77 expression was regulated. We showed that levels of Nur77 were elevated in a majority of human colon tumors (9/12) compared to their nontumorous tissues and that Nur77 expression could be strongly induced by different colonic carcinogens including deoxycholic acid (DCA). DCA-induced Nur77 expression resulted in up-regulation of antiapoptotic BRE and angiogenic VEGF, and it enhanced the growth, colony formation, and migration of colon cancer cells. In studying the mechanism by which Nur77 was regulated in colon cancer cells, we found that β-catenin was involved in induction of Nur77 expression through its activation of the transcriptional activity of AP-1 (c-Fos/c-Jun) that bound to and transactivated the Nur77 promoter. Together, our results demonstrate that Nur77 acts to promote the growth and survival of colon cancer cells and serves as an important mediator of the Wnt/β-catenin and AP-1 signaling pathways. © FASEB.
ISSN0892-6638
2011 Impact Factor: 5.712
2011 SCImago Journal Rankings: 0.680
DOIhttp://dx.doi.org/10.1096/fj.10-166462
PubMed Central IDPMC3005431
ReferencesReferences in Scopus
GrantsInvolvement of orphan nuclear receptor Nurr77 in regulating \xE1-catenin turnover and signaling
DC Field
Value
dc.contributor.authorWu, H
dc.contributor.authorLin, Y
dc.contributor.authorLi, W
dc.contributor.authorSun, Z
dc.contributor.authorGao, W
dc.contributor.authorZhang, H
dc.contributor.authorXie, L
dc.contributor.authorJiang, F
dc.contributor.authorQin, B
dc.contributor.authorYan, T
dc.contributor.authorChen, L
dc.contributor.authorZhao, Y
dc.contributor.authorCao, X
dc.contributor.authorWu, Y
dc.contributor.authorLin, B
dc.contributor.authorZhou, H
dc.contributor.authorWong, AST
dc.contributor.authorZhang, XK
dc.contributor.authorZeng, JZ
dc.date.accessioned2011-07-27T02:11:46Z
dc.date.available2011-07-27T02:11:46Z
dc.date.issued2011
dc.description.abstractThe orphan nuclear receptor Nur77 is an immediate-early response gene whose expression is rapidly induced by various extracellular stimuli. The aims of this study were to study the role of Nur77 expression in the growth and survival of colon cancer cells and the mechanism by which Nur77 expression was regulated. We showed that levels of Nur77 were elevated in a majority of human colon tumors (9/12) compared to their nontumorous tissues and that Nur77 expression could be strongly induced by different colonic carcinogens including deoxycholic acid (DCA). DCA-induced Nur77 expression resulted in up-regulation of antiapoptotic BRE and angiogenic VEGF, and it enhanced the growth, colony formation, and migration of colon cancer cells. In studying the mechanism by which Nur77 was regulated in colon cancer cells, we found that β-catenin was involved in induction of Nur77 expression through its activation of the transcriptional activity of AP-1 (c-Fos/c-Jun) that bound to and transactivated the Nur77 promoter. Together, our results demonstrate that Nur77 acts to promote the growth and survival of colon cancer cells and serves as an important mediator of the Wnt/β-catenin and AP-1 signaling pathways. © FASEB.
dc.description.grantInvolvement of orphan nuclear receptor Nurr77 in regulating \xE1-catenin turnover and signaling
dc.description.grantcode101473
dc.description.naturelink_to_OA_fulltext
dc.identifier.citationFaseb Journal, 2011, v. 25 n. 1, p. 192-205 [How to Cite?]
DOI: http://dx.doi.org/10.1096/fj.10-166462
dc.identifier.doihttp://dx.doi.org/10.1096/fj.10-166462
dc.identifier.epage205
dc.identifier.hkuros188959
dc.identifier.isiWOS:000285869500018
Funding AgencyGrant Number
863 Program2007AA09Z404
National Natural Science Foundation of China (NSFC)30971445
Key Science and Technology Planning Project2007I0023
Natural Science Foundation of Fujian Province, China2009J01198
NSFC/Hong Kong Research Grants Council (RGC)30931160431
U.S. National Institutes of HealthCA109345
CA140980
GM089927
U.S. Army Medical Research and Material CommandPCRPW81XWH-08-1-0478
Natural Science Foundation of Fujian Province2008Y0062
N_HKU 735/09
Funding Information:

This work was in part supported by grants to J.-Z.Z. from the 863 Program (2007AA09Z404), the National Natural Science Foundation of China (NSFC; 30971445), the Key Science and Technology Planning Project (2007I0023), the Natural Science Foundation of Fujian Province, China (2009J01198), and the NSFC/Hong Kong Research Grants Council (RGC; 30931160431), a grant to A.S.-T.W. (N_HKU 735/09), and grants to X.Z. from the U.S. National Institutes of Health (CA109345, CA140980, GM089927), the U.S. Army Medical Research and Material Command (PCRPW81XWH-08-1-0478), and the Natural Science Foundation of Fujian Province (2008Y0062). The authors declare no conflicts of interest.

dc.identifier.issn0892-6638
2011 Impact Factor: 5.712
2011 SCImago Journal Rankings: 0.680
dc.identifier.issue1
dc.identifier.pmcidPMC3005431
dc.identifier.pmid20847229
dc.identifier.scopuseid_2-s2.0-78651376455
dc.identifier.spage192
dc.identifier.urihttp://hdl.handle.net/10722/136256
dc.identifier.volume25
dc.languageeng
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
dc.publisher.placeUnited States
dc.relation.ispartofFASEB Journal
dc.relation.referencesReferences in Scopus
dc.subject.meshCell Proliferation
dc.subject.meshColonic Neoplasms - genetics - metabolism - pathology
dc.subject.meshImmunohistochemistry
dc.subject.meshNuclear Receptor Subfamily 4, Group A, Member 1 - genetics - metabolism
dc.subject.meshbeta Catenin - genetics - metabolism
dc.subjectAP-1
dc.subjectBile acid
dc.subjectJNK
dc.subjectPI3K
dc.titleRegulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells
dc.typeArticle
Author Affiliations
  1. Sanford-Burnham Medical Research Institute
  2. Xiamen University
  3. The University of Hong Kong