File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Orexins and their receptors from fish to mammals: A comparative approach

TitleOrexins and their receptors from fish to mammals: A comparative approach
Authors
KeywordsEvolution
Orexin
Orexin receptor
Issue Date2011
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcen
Citation
General And Comparative Endocrinology, 2011, v. 171 n. 2, p. 124-130 How to Cite?
AbstractAlthough recently discovered, orexins have been rapidly established as important neuropeptides in regulating physiological processes including food intake, sleep/wake cycles and reproduction through binding to two class B G protein-coupled receptors (OX1R and OX2R). To date, a handful of sequences for orexins and their receptors ranging from fish to mammalian species have been identified, allowing a glimpse into their evolution. Structurally, the genetic and molecular organization of the peptides and receptors amongst vertebrates are highly similar, underlining the strong evolutionary pressure that has been exerted to preserve structure and ultimately function. Furthermore, the absence of invertebrate orexin-like sequences suggests early vertebrates as the origin from which orexins evolved. With respect to the receptors, OX2R is probably evolutionary more ancient whilst OX1R is specific to mammalian species and evolved only during this later lineage. In common to all vertebrates studied, the hypothalamus remains to be the key brain region in which orexinergic neurons and fibers are localized in, establishing orexin to be an important player in regulating physiological processes especially those related to food intake and energy metabolism. To allow better understanding of the evolution of orexins and their receptors, this review will provide a comparative approach to their structures and functions in vertebrates. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/136253
ISSN
2015 Impact Factor: 2.667
2015 SCImago Journal Rankings: 1.245
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Government RGC7638/09
Committee on Research and Conference1159084
Funding Information:

This work was supported by the Hong Kong Government RGC grants 7638/09 to Billy K.C. Chow and the Committee on Research and Conference Grants 1159084 to Leo T.O. Lee.

References

 

DC FieldValueLanguage
dc.contributor.authorWong, KKYen_HK
dc.contributor.authorNg, SYLen_HK
dc.contributor.authorLee, LTOen_HK
dc.contributor.authorNg, HKHen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2011-07-27T02:11:44Z-
dc.date.available2011-07-27T02:11:44Z-
dc.date.issued2011en_HK
dc.identifier.citationGeneral And Comparative Endocrinology, 2011, v. 171 n. 2, p. 124-130en_HK
dc.identifier.issn0016-6480en_HK
dc.identifier.urihttp://hdl.handle.net/10722/136253-
dc.description.abstractAlthough recently discovered, orexins have been rapidly established as important neuropeptides in regulating physiological processes including food intake, sleep/wake cycles and reproduction through binding to two class B G protein-coupled receptors (OX1R and OX2R). To date, a handful of sequences for orexins and their receptors ranging from fish to mammalian species have been identified, allowing a glimpse into their evolution. Structurally, the genetic and molecular organization of the peptides and receptors amongst vertebrates are highly similar, underlining the strong evolutionary pressure that has been exerted to preserve structure and ultimately function. Furthermore, the absence of invertebrate orexin-like sequences suggests early vertebrates as the origin from which orexins evolved. With respect to the receptors, OX2R is probably evolutionary more ancient whilst OX1R is specific to mammalian species and evolved only during this later lineage. In common to all vertebrates studied, the hypothalamus remains to be the key brain region in which orexinergic neurons and fibers are localized in, establishing orexin to be an important player in regulating physiological processes especially those related to food intake and energy metabolism. To allow better understanding of the evolution of orexins and their receptors, this review will provide a comparative approach to their structures and functions in vertebrates. © 2011 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcenen_HK
dc.relation.ispartofGeneral and Comparative Endocrinologyen_HK
dc.subjectEvolutionen_HK
dc.subjectOrexinen_HK
dc.subjectOrexin receptoren_HK
dc.subject.meshFishes - genetics - metabolism-
dc.subject.meshIntracellular Signaling Peptides and Proteins - chemistry - genetics - metabolism-
dc.subject.meshMammals - genetics - metabolism-
dc.subject.meshNeuropeptides - chemistry - genetics - metabolism-
dc.subject.meshReceptors, G-Protein-Coupled - chemistry - genetics - metabolism-
dc.titleOrexins and their receptors from fish to mammals: A comparative approachen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityLee, LTO=rp00727en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ygcen.2011.01.001en_HK
dc.identifier.pmid21216246-
dc.identifier.scopuseid_2-s2.0-79952487830en_HK
dc.identifier.hkuros188277en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952487830&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume171en_HK
dc.identifier.issue2en_HK
dc.identifier.spage124en_HK
dc.identifier.epage130en_HK
dc.identifier.isiWOS:000288590100003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, KKY=42462630500en_HK
dc.identifier.scopusauthoridNg, SYL=36499721800en_HK
dc.identifier.scopusauthoridLee, LTO=8367269000en_HK
dc.identifier.scopusauthoridNg, HKH=42462263600en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK
dc.identifier.citeulike8609107-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats