Article: Phenolic tyrosinase inhibitors from the stems of Cudrania cochinchinensis

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TitlePhenolic tyrosinase inhibitors from the stems of Cudrania cochinchinensis
AuthorsZheng, ZP1
Zhu, Q1
Fan, CL2
Tan, HY1
Wang, M1
Issue Date2011
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/fo
CitationFood And Function, 2011, v. 2 n. 5, p. 259-264 [How to Cite?]
DOI: http://dx.doi.org/10.1039/c1fo10033e
AbstractThe phytochemcal profiles of Cudrania cochinchinensis leaf, twig, stem and root were compared by HPLC analysis. It was found that C. cochinchinensis stem extract contained some unknown natural products with potential tyrosinase inhibitory activities. Therefore, the chemical constitutes in extract (95% ethanol) of C. cochinchinensis stem were further investigated in this study. A new racemic mixture, (±)2,3-cis-dihydromorin, and fifteen known phenolic compounds, dihydrokaempferol 7-O-β-d-qlucopyranoside, skimmin, quercetin-7-O-β-d-glucoside, 2,3-dihydroquercetin 7-O-β-d-glucoside, kaempferol-7-O-β-glucopyranoside, quercetin-3,7-di-O-β-d-glucoside, morin-7-O-β-d-glucoside, 1,3,5,8-tetrahydroxyxanthen-9-one, 2,3-trans-dihydromorin, aromadendrin, oxyresveratrol, genistin, protocatechuic acid, kaempferol 3,7-di-O-β-glucopyranoside, and naringenin were isolated. Spectral techniques (MS, 1H NMR and 13C NMR) were utilized for their structural identification and their inhibitory activities on mushroom tyrosinase were also evaluated. The results showed that tyrosinase inhibitory activities of (±)2,3-cis-dihydromorin (IC 50 = 31.1 μM), 2,3-trans-dihydromorin (IC 50 = 21.1 μM), and oxyresveratrol (IC 50 = 2.33 μM), were more potent than that of kojic acid (IC 50 = 50.8 μM), a well-known tyrosinase inhibitor, indicating that Cudrania cochinchinensis stem will be a great potential agent for the development of effective natural tyrosinase inhibitors. © 2011 The Royal Society of Chemistry.
ISSN2042-6496
2011 Impact Factor: 1.179
DOIhttp://dx.doi.org/10.1039/c1fo10033e
ISI Accession Number IDWOS:000291039200005
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorZheng, ZP
dc.contributor.authorZhu, Q
dc.contributor.authorFan, CL
dc.contributor.authorTan, HY
dc.contributor.authorWang, M
dc.date.accessioned2011-07-27T02:11:39Z
dc.date.available2011-07-27T02:11:39Z
dc.date.issued2011
dc.description.abstractThe phytochemcal profiles of Cudrania cochinchinensis leaf, twig, stem and root were compared by HPLC analysis. It was found that C. cochinchinensis stem extract contained some unknown natural products with potential tyrosinase inhibitory activities. Therefore, the chemical constitutes in extract (95% ethanol) of C. cochinchinensis stem were further investigated in this study. A new racemic mixture, (±)2,3-cis-dihydromorin, and fifteen known phenolic compounds, dihydrokaempferol 7-O-β-d-qlucopyranoside, skimmin, quercetin-7-O-β-d-glucoside, 2,3-dihydroquercetin 7-O-β-d-glucoside, kaempferol-7-O-β-glucopyranoside, quercetin-3,7-di-O-β-d-glucoside, morin-7-O-β-d-glucoside, 1,3,5,8-tetrahydroxyxanthen-9-one, 2,3-trans-dihydromorin, aromadendrin, oxyresveratrol, genistin, protocatechuic acid, kaempferol 3,7-di-O-β-glucopyranoside, and naringenin were isolated. Spectral techniques (MS, 1H NMR and 13C NMR) were utilized for their structural identification and their inhibitory activities on mushroom tyrosinase were also evaluated. The results showed that tyrosinase inhibitory activities of (±)2,3-cis-dihydromorin (IC 50 = 31.1 μM), 2,3-trans-dihydromorin (IC 50 = 21.1 μM), and oxyresveratrol (IC 50 = 2.33 μM), were more potent than that of kojic acid (IC 50 = 50.8 μM), a well-known tyrosinase inhibitor, indicating that Cudrania cochinchinensis stem will be a great potential agent for the development of effective natural tyrosinase inhibitors. © 2011 The Royal Society of Chemistry.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationFood And Function, 2011, v. 2 n. 5, p. 259-264 [How to Cite?]
DOI: http://dx.doi.org/10.1039/c1fo10033e
dc.identifier.doihttp://dx.doi.org/10.1039/c1fo10033e
dc.identifier.epage264
dc.identifier.hkuros186786
dc.identifier.isiWOS:000291039200005
dc.identifier.issn2042-6496
2011 Impact Factor: 1.179
dc.identifier.issue5
dc.identifier.pmid21779564
dc.identifier.scopuseid_2-s2.0-79957860606
dc.identifier.spage259
dc.identifier.urihttp://hdl.handle.net/10722/136245
dc.identifier.volume2
dc.languageeng
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/fo
dc.publisher.placeUnited Kingdom
dc.relation.ispartofFood and Function
dc.relation.referencesReferences in Scopus
dc.subject.meshEnzyme Inhibitors - pharmacology
dc.subject.meshMonophenol Monooxygenase - metabolism
dc.subject.meshMoraceae - chemistry
dc.subject.meshPhenols - pharmacology
dc.subject.meshPlant Stems - chemistry
dc.titlePhenolic tyrosinase inhibitors from the stems of Cudrania cochinchinensis
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Jinan University