File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Phenolic tyrosinase inhibitors from the stems of Cudrania cochinchinensis

TitlePhenolic tyrosinase inhibitors from the stems of Cudrania cochinchinensis
Authors
Issue Date2011
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/fo
Citation
Food And Function, 2011, v. 2 n. 5, p. 259-264 How to Cite?
Abstract
The phytochemcal profiles of Cudrania cochinchinensis leaf, twig, stem and root were compared by HPLC analysis. It was found that C. cochinchinensis stem extract contained some unknown natural products with potential tyrosinase inhibitory activities. Therefore, the chemical constitutes in extract (95% ethanol) of C. cochinchinensis stem were further investigated in this study. A new racemic mixture, (±)2,3-cis-dihydromorin, and fifteen known phenolic compounds, dihydrokaempferol 7-O-β-d-qlucopyranoside, skimmin, quercetin-7-O-β-d-glucoside, 2,3-dihydroquercetin 7-O-β-d-glucoside, kaempferol-7-O-β-glucopyranoside, quercetin-3,7-di-O-β-d-glucoside, morin-7-O-β-d-glucoside, 1,3,5,8-tetrahydroxyxanthen-9-one, 2,3-trans-dihydromorin, aromadendrin, oxyresveratrol, genistin, protocatechuic acid, kaempferol 3,7-di-O-β-glucopyranoside, and naringenin were isolated. Spectral techniques (MS, 1H NMR and 13C NMR) were utilized for their structural identification and their inhibitory activities on mushroom tyrosinase were also evaluated. The results showed that tyrosinase inhibitory activities of (±)2,3-cis-dihydromorin (IC 50 = 31.1 μM), 2,3-trans-dihydromorin (IC 50 = 21.1 μM), and oxyresveratrol (IC 50 = 2.33 μM), were more potent than that of kojic acid (IC 50 = 50.8 μM), a well-known tyrosinase inhibitor, indicating that Cudrania cochinchinensis stem will be a great potential agent for the development of effective natural tyrosinase inhibitors. © 2011 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/136245
ISSN
2013 Impact Factor: 2.907
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, ZPen_HK
dc.contributor.authorZhu, Qen_HK
dc.contributor.authorFan, CLen_HK
dc.contributor.authorTan, HYen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2011-07-27T02:11:39Z-
dc.date.available2011-07-27T02:11:39Z-
dc.date.issued2011en_HK
dc.identifier.citationFood And Function, 2011, v. 2 n. 5, p. 259-264en_HK
dc.identifier.issn2042-6496en_HK
dc.identifier.urihttp://hdl.handle.net/10722/136245-
dc.description.abstractThe phytochemcal profiles of Cudrania cochinchinensis leaf, twig, stem and root were compared by HPLC analysis. It was found that C. cochinchinensis stem extract contained some unknown natural products with potential tyrosinase inhibitory activities. Therefore, the chemical constitutes in extract (95% ethanol) of C. cochinchinensis stem were further investigated in this study. A new racemic mixture, (±)2,3-cis-dihydromorin, and fifteen known phenolic compounds, dihydrokaempferol 7-O-β-d-qlucopyranoside, skimmin, quercetin-7-O-β-d-glucoside, 2,3-dihydroquercetin 7-O-β-d-glucoside, kaempferol-7-O-β-glucopyranoside, quercetin-3,7-di-O-β-d-glucoside, morin-7-O-β-d-glucoside, 1,3,5,8-tetrahydroxyxanthen-9-one, 2,3-trans-dihydromorin, aromadendrin, oxyresveratrol, genistin, protocatechuic acid, kaempferol 3,7-di-O-β-glucopyranoside, and naringenin were isolated. Spectral techniques (MS, 1H NMR and 13C NMR) were utilized for their structural identification and their inhibitory activities on mushroom tyrosinase were also evaluated. The results showed that tyrosinase inhibitory activities of (±)2,3-cis-dihydromorin (IC 50 = 31.1 μM), 2,3-trans-dihydromorin (IC 50 = 21.1 μM), and oxyresveratrol (IC 50 = 2.33 μM), were more potent than that of kojic acid (IC 50 = 50.8 μM), a well-known tyrosinase inhibitor, indicating that Cudrania cochinchinensis stem will be a great potential agent for the development of effective natural tyrosinase inhibitors. © 2011 The Royal Society of Chemistry.en_HK
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/foen_HK
dc.relation.ispartofFood and Functionen_HK
dc.subject.meshEnzyme Inhibitors - pharmacology-
dc.subject.meshMonophenol Monooxygenase - metabolism-
dc.subject.meshMoraceae - chemistry-
dc.subject.meshPhenols - pharmacology-
dc.subject.meshPlant Stems - chemistry-
dc.titlePhenolic tyrosinase inhibitors from the stems of Cudrania cochinchinensisen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, M: mfwang@hku.hken_HK
dc.identifier.authorityWang, M=rp00800en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c1fo10033een_HK
dc.identifier.pmid21779564-
dc.identifier.scopuseid_2-s2.0-79957860606en_HK
dc.identifier.hkuros186786en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79957860606&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue5en_HK
dc.identifier.spage259en_HK
dc.identifier.epage264en_HK
dc.identifier.isiWOS:000291039200005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZheng, ZP=8451746600en_HK
dc.identifier.scopusauthoridZhu, Q=54909442800en_HK
dc.identifier.scopusauthoridFan, CL=7402656909en_HK
dc.identifier.scopusauthoridTan, HY=54391749200en_HK
dc.identifier.scopusauthoridWang, M=7406691844en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats