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Article: Protective actions of microalgae against endogenous and exogenous advanced glycation endproducts (AGEs) in human retinal pigment epithelial cells

TitleProtective actions of microalgae against endogenous and exogenous advanced glycation endproducts (AGEs) in human retinal pigment epithelial cells
Authors
Issue Date2011
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/fo
Citation
Food And Function, 2011, v. 2 n. 5, p. 251-258 How to Cite?
Abstract
The formation and accumulation of advanced glycation endproducts (AGEs) is a key pathophysiological process involved in various diabetic complications such as diabetic retinopathy. In the present study, for the first time, protective effects of three microalgal strains, including their extracts and active compounds, against both endogenous and exogenous AGEs in cell-based models were investigated. Results showed that in cultured human-derived retinal pigment epithelial ARPE-19 cells, the extract of Chlorella zofingiensis and its nutritional ingredient astaxanthin exhibited significant inhibitory effects on the formation of endogenous N ε-carboxymethyllysine (CML), a key AGE representative, through the suppression of intracellular oxidative stress. On the other hand, extracts of Chlorella zofingiensis, Chlorella protothecoides and Nitzschia laevis as well as their nutritional ingredients, namely astaxanthin, lutein and eicosapentaenoic acid (EPA), attenuated the deleterious effects induced by exogenous AGEs, such as cell proliferation and mRNA upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2, which are critical steps involved in the pathogenesis of diabetic retinopathy. These results suggested the positive roles of astaxanthin, lutein and EPA in controlling the development of diabetes. These microalgae, therefore, might be regarded as beneficial foods and preventive agent choices for patients with diabetic retinopathy. © 2011 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/136244
ISSN
2013 Impact Factor: 2.907
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSun, Zen_HK
dc.contributor.authorLiu, Jen_HK
dc.contributor.authorZeng, Xen_HK
dc.contributor.authorHuangfu, Jen_HK
dc.contributor.authorJiang, Yen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorChen, Fen_HK
dc.date.accessioned2011-07-27T02:11:38Z-
dc.date.available2011-07-27T02:11:38Z-
dc.date.issued2011en_HK
dc.identifier.citationFood And Function, 2011, v. 2 n. 5, p. 251-258en_HK
dc.identifier.issn2042-6496en_HK
dc.identifier.urihttp://hdl.handle.net/10722/136244-
dc.description.abstractThe formation and accumulation of advanced glycation endproducts (AGEs) is a key pathophysiological process involved in various diabetic complications such as diabetic retinopathy. In the present study, for the first time, protective effects of three microalgal strains, including their extracts and active compounds, against both endogenous and exogenous AGEs in cell-based models were investigated. Results showed that in cultured human-derived retinal pigment epithelial ARPE-19 cells, the extract of Chlorella zofingiensis and its nutritional ingredient astaxanthin exhibited significant inhibitory effects on the formation of endogenous N ε-carboxymethyllysine (CML), a key AGE representative, through the suppression of intracellular oxidative stress. On the other hand, extracts of Chlorella zofingiensis, Chlorella protothecoides and Nitzschia laevis as well as their nutritional ingredients, namely astaxanthin, lutein and eicosapentaenoic acid (EPA), attenuated the deleterious effects induced by exogenous AGEs, such as cell proliferation and mRNA upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2, which are critical steps involved in the pathogenesis of diabetic retinopathy. These results suggested the positive roles of astaxanthin, lutein and EPA in controlling the development of diabetes. These microalgae, therefore, might be regarded as beneficial foods and preventive agent choices for patients with diabetic retinopathy. © 2011 The Royal Society of Chemistry.en_HK
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/foen_HK
dc.relation.ispartofFood and Functionen_HK
dc.subject.meshDiabetic Retinopathy - drug therapy - etiology - pathology-
dc.subject.meshEicosapentaenoic Acid - pharmacology-
dc.subject.meshGlycosylation End Products, Advanced - adverse effects - metabolism-
dc.subject.meshLutein - pharmacology-
dc.subject.meshMicroalgae - chemistry-
dc.titleProtective actions of microalgae against endogenous and exogenous advanced glycation endproducts (AGEs) in human retinal pigment epithelial cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, M: mfwang@hku.hken_HK
dc.identifier.emailChen, F: sfchen@hku.hken_HK
dc.identifier.authorityWang, M=rp00800en_HK
dc.identifier.authorityChen, F=rp00672en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c1fo10021aen_HK
dc.identifier.pmid21779563-
dc.identifier.scopuseid_2-s2.0-79957808756en_HK
dc.identifier.hkuros186785en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79957808756&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue5en_HK
dc.identifier.spage251en_HK
dc.identifier.epage258en_HK
dc.identifier.isiWOS:000291039200004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSun, Z=22837137300en_HK
dc.identifier.scopusauthoridLiu, J=36064082300en_HK
dc.identifier.scopusauthoridZeng, X=35760592200en_HK
dc.identifier.scopusauthoridHuangfu, J=36997828100en_HK
dc.identifier.scopusauthoridJiang, Y=24605346600en_HK
dc.identifier.scopusauthoridWang, M=7406691844en_HK
dc.identifier.scopusauthoridChen, F=7404907980en_HK

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