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Article: Steroidal saponins and ecdysterone from Asparagus filicinus and their cytotoxic activities

TitleSteroidal saponins and ecdysterone from Asparagus filicinus and their cytotoxic activities
Authors
KeywordsAsparagus filicinus
Cytotoxic activity
Ecdysterone
Liliaceae
Steroidal glycoside
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/steroids
Citation
Steroids, 2010, v. 75 n. 10, p. 734-739 How to Cite?
AbstractTwo new spirostanoides, filiasparosides E (1) and F (2), one new furostanoside, filiasparoside G (3), and one new ecdysterone, stachysterone A-20, 22-acetonide (4), together with six known steroidal saponins, asparagusin A (5), filiasparoside A (6), filiasparoside B (7), aspafilioside A (8), aspafilioside B (9), and filiasparoside C (10) were isolated from the roots of Asparagus filicinus Buch.-Ham. Their structures were elucidated on the basis of spectroscopic and chemical evidence. Compounds 110 were investigated for their cytotoxicities against human breast adenocarcinoma MDA-MB-231 cell line and compounds 810 exhibited cytotoxic activities with IC 50 values ranging from 3.4 to 6.6μM. © 2010 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/136240
ISSN
2015 Impact Factor: 2.513
2015 SCImago Journal Rankings: 0.876
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, JJen_HK
dc.contributor.authorCheng, KWen_HK
dc.contributor.authorZuo, XFen_HK
dc.contributor.authorWang, MFen_HK
dc.contributor.authorLi, Pen_HK
dc.contributor.authorZhang, LYen_HK
dc.contributor.authorWang, Hen_HK
dc.contributor.authorYe, WCen_HK
dc.date.accessioned2011-07-27T02:05:35Z-
dc.date.available2011-07-27T02:05:35Z-
dc.date.issued2010en_HK
dc.identifier.citationSteroids, 2010, v. 75 n. 10, p. 734-739en_HK
dc.identifier.issn0039-128Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/136240-
dc.description.abstractTwo new spirostanoides, filiasparosides E (1) and F (2), one new furostanoside, filiasparoside G (3), and one new ecdysterone, stachysterone A-20, 22-acetonide (4), together with six known steroidal saponins, asparagusin A (5), filiasparoside A (6), filiasparoside B (7), aspafilioside A (8), aspafilioside B (9), and filiasparoside C (10) were isolated from the roots of Asparagus filicinus Buch.-Ham. Their structures were elucidated on the basis of spectroscopic and chemical evidence. Compounds 110 were investigated for their cytotoxicities against human breast adenocarcinoma MDA-MB-231 cell line and compounds 810 exhibited cytotoxic activities with IC 50 values ranging from 3.4 to 6.6μM. © 2010 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/steroidsen_HK
dc.relation.ispartofSteroidsen_HK
dc.subjectAsparagus filicinusen_HK
dc.subjectCytotoxic activityen_HK
dc.subjectEcdysteroneen_HK
dc.subjectLiliaceaeen_HK
dc.subjectSteroidal glycosideen_HK
dc.subject.meshAsparagus Plant - chemistry-
dc.subject.meshCell Line, Tumor-
dc.subject.meshEcdysterone - chemistry - pharmacology-
dc.subject.meshPlant Extracts - chemistry - pharmacology-
dc.subject.meshSaponins - chemistry - pharmacology-
dc.titleSteroidal saponins and ecdysterone from Asparagus filicinus and their cytotoxic activitiesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0039-128X&volume=75&issue=10&spage=734&epage=739&date=2010&atitle=Steroidal+saponins+and+ecdysterone+from+Asparagus+filicinus+and+their+cytotoxic+activities-
dc.identifier.emailWang, MF: mfwang@hku.hken_HK
dc.identifier.authorityWang, MF=rp00800en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.steroids.2010.05.002en_HK
dc.identifier.pmid20470812-
dc.identifier.scopuseid_2-s2.0-77954311821en_HK
dc.identifier.hkuros186778en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954311821&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume75en_HK
dc.identifier.issue10en_HK
dc.identifier.spage734en_HK
dc.identifier.epage739en_HK
dc.identifier.isiWOS:000280046700016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, JJ=8298828200en_HK
dc.identifier.scopusauthoridCheng, KW=12141247000en_HK
dc.identifier.scopusauthoridZuo, XF=35075615300en_HK
dc.identifier.scopusauthoridWang, MF=7406691844en_HK
dc.identifier.scopusauthoridLi, P=7404772682en_HK
dc.identifier.scopusauthoridZhang, LY=8917926900en_HK
dc.identifier.scopusauthoridWang, H=10240993900en_HK
dc.identifier.scopusauthoridYe, WC=7201560816en_HK
dc.identifier.citeulike7181984-

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