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Article: Porcine reproductive and respiratory syndrome virus in Ontario, Canada 1999 to 2010: Genetic diversity and restriction fragment length polymorphisms

TitlePorcine reproductive and respiratory syndrome virus in Ontario, Canada 1999 to 2010: Genetic diversity and restriction fragment length polymorphisms
Authors
Issue Date2011
PublisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org
Citation
Journal Of General Virology, 2011, v. 92 n. 6, p. 1391-1397 How to Cite?
AbstractClassification of Ontario porcine reproductive and respiratory syndrome virus (PRRSV) field isolates (n=5505) from 1999 to 2010, based on a global type 2 PRRSV ORF5 phylogenetic framework, revealed genetic diversity comparable to PRRSV in the USA, with sequences assigned to five of nine lineages (1, 2, 5, 8 and 9). Importantly, the tree topology indicated a Canadian ancestry for the highly virulent MN184-related strains that first emerged in 2001 in the USA. Mapping of the RFLP patterns onto the phylogenetic tree revealed numerous examples of different RFLP patterns located within the same phylogenetic cluster. Statistical analysis showed occurrences where similar RFLP patterns masked diverse genetic distances and instances of close genetic proximity with divergent RFLP patterns. Collectively, extensive genetic diversity prevails in type 2 PRRSV in one region of the North American swine industry, and it is not described adequately by RFLP typing, which might have value in differentiating strains at the local farm level. © 2011 SGM.
Persistent Identifierhttp://hdl.handle.net/10722/136237
ISSN
2015 Impact Factor: 3.192
2015 SCImago Journal Rankings: 1.741
ISI Accession Number ID
Funding AgencyGrant Number
Strategic Research Theme of Infection and Immunology, The University of Hong Kong
Funding Information:

This work was partially supported by the Strategic Research Theme of Infection and Immunology, The University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorBrar, MSen_HK
dc.contributor.authorShi, Men_HK
dc.contributor.authorGe, Len_HK
dc.contributor.authorCarman, Sen_HK
dc.contributor.authorMurtaugh, MPen_HK
dc.contributor.authorLeung, FCCen_HK
dc.date.accessioned2011-07-27T02:05:33Z-
dc.date.available2011-07-27T02:05:33Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of General Virology, 2011, v. 92 n. 6, p. 1391-1397en_HK
dc.identifier.issn0022-1317en_HK
dc.identifier.urihttp://hdl.handle.net/10722/136237-
dc.description.abstractClassification of Ontario porcine reproductive and respiratory syndrome virus (PRRSV) field isolates (n=5505) from 1999 to 2010, based on a global type 2 PRRSV ORF5 phylogenetic framework, revealed genetic diversity comparable to PRRSV in the USA, with sequences assigned to five of nine lineages (1, 2, 5, 8 and 9). Importantly, the tree topology indicated a Canadian ancestry for the highly virulent MN184-related strains that first emerged in 2001 in the USA. Mapping of the RFLP patterns onto the phylogenetic tree revealed numerous examples of different RFLP patterns located within the same phylogenetic cluster. Statistical analysis showed occurrences where similar RFLP patterns masked diverse genetic distances and instances of close genetic proximity with divergent RFLP patterns. Collectively, extensive genetic diversity prevails in type 2 PRRSV in one region of the North American swine industry, and it is not described adequately by RFLP typing, which might have value in differentiating strains at the local farm level. © 2011 SGM.en_HK
dc.languageengen_US
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.orgen_HK
dc.relation.ispartofJournal of General Virologyen_HK
dc.rightsJournal of general virology. Copyright © Society for General Microbiology.-
dc.subject.meshGenetic Variation-
dc.subject.meshPolymorphism, Restriction Fragment Length-
dc.subject.meshPorcine Reproductive and Respiratory Syndrome - virology-
dc.subject.meshPorcine respiratory and reproductive syndrome virus - classification - genetics - isolation and purification-
dc.subject.meshSwine-
dc.titlePorcine reproductive and respiratory syndrome virus in Ontario, Canada 1999 to 2010: Genetic diversity and restriction fragment length polymorphismsen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, FCC=rp00731en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1099/vir.0.030155-0en_HK
dc.identifier.pmid21346028-
dc.identifier.scopuseid_2-s2.0-79956297855en_HK
dc.identifier.hkuros186075en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956297855&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume92en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1391en_HK
dc.identifier.epage1397en_HK
dc.identifier.isiWOS:000291370100016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBrar, MS=44161059200en_HK
dc.identifier.scopusauthoridShi, M=25951822000en_HK
dc.identifier.scopusauthoridGe, L=36645965000en_HK
dc.identifier.scopusauthoridCarman, S=7003877448en_HK
dc.identifier.scopusauthoridMurtaugh, MP=7005137127en_HK
dc.identifier.scopusauthoridLeung, FCC=7103078633en_HK

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