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Conference Paper: Evaluation of DNA mixtures accounting for sampling variability

TitleEvaluation of DNA mixtures accounting for sampling variability
Authors
KeywordsBayesian inference
Hardy-Weinberg equilibrium
Relatedness coefficient
Likelihood ratio
Mixed stain
Relative
Issue Date2010
PublisherSpringer.
Citation
The 19th International Symposium on Computational Statistics (COMPSTAT 2010), Paris, France, 22-27 August 2010. In Proceedings of COMPSTAT2010, 2010, pt. 16, p. 437-444 How to Cite?
AbstractIn the conventional evaluation of DNA mixtures, the allele frequencies are often taken as constants. But they are in fact estimated from a sample taken from a population and thus the variability of the estimates has to be taken into account. Within a Bayesian framework, the evaluation of DNA mixtures accounting for sampling variability in the population database of allele frequencies are discussed in this paper. The concise and general formulae are provided for calculating the likelihood ratio when the people involved are biologically related. The implementation of the formula is demonstrated on the analysis of a real example. The resulting formulae are shown to be more conservative, which is generally more favorable to the defendant.
DescriptionSession - CP6 Biostatistics & Bio-Computing 2: no. 90
Persistent Identifierhttp://hdl.handle.net/10722/136198
ISBN

 

DC FieldValueLanguage
dc.contributor.authorChung, YKen_US
dc.contributor.authorHu, Yen_US
dc.contributor.authorZhu, DGen_US
dc.contributor.authorFung, WKen_US
dc.date.accessioned2011-07-27T02:04:33Z-
dc.date.available2011-07-27T02:04:33Z-
dc.date.issued2010en_US
dc.identifier.citationThe 19th International Symposium on Computational Statistics (COMPSTAT 2010), Paris, France, 22-27 August 2010. In Proceedings of COMPSTAT2010, 2010, pt. 16, p. 437-444en_US
dc.identifier.isbn978-3-7908-2603-6en_US
dc.identifier.urihttp://hdl.handle.net/10722/136198-
dc.descriptionSession - CP6 Biostatistics & Bio-Computing 2: no. 90-
dc.description.abstractIn the conventional evaluation of DNA mixtures, the allele frequencies are often taken as constants. But they are in fact estimated from a sample taken from a population and thus the variability of the estimates has to be taken into account. Within a Bayesian framework, the evaluation of DNA mixtures accounting for sampling variability in the population database of allele frequencies are discussed in this paper. The concise and general formulae are provided for calculating the likelihood ratio when the people involved are biologically related. The implementation of the formula is demonstrated on the analysis of a real example. The resulting formulae are shown to be more conservative, which is generally more favorable to the defendant.-
dc.languageengen_US
dc.publisherSpringer.en_US
dc.relation.ispartofProceedings of COMPSTAT2010en_US
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectBayesian inference-
dc.subjectHardy-Weinberg equilibrium-
dc.subjectRelatedness coefficient-
dc.subjectLikelihood ratio-
dc.subjectMixed stain-
dc.subjectRelative-
dc.titleEvaluation of DNA mixtures accounting for sampling variabilityen_US
dc.typeConference_Paperen_US
dc.identifier.emailChung, YK: yukchung@hku.hken_US
dc.identifier.emailHu, Y: yqhu@hku.hken_US
dc.identifier.emailFung, WK: wingfung@hku.hken_US
dc.identifier.authorityHu, Y=rp00708en_US
dc.identifier.authorityFung, WK=rp00696en_US
dc.identifier.doi10.1007/978-3-7908-2604-3_42-
dc.identifier.hkuros187608en_US
dc.identifier.volumept. 16-
dc.identifier.spage437en_US
dc.identifier.epage444en_US
dc.publisher.placeHeidelberg-
dc.description.otherThe 19th International Symposium on Computational Statistics (COMPSTAT 2010), Paris, France, 22-27 August 2010. In Proceedings of COMPSTAT2010, 2010, pt. 16, p. 437-444-

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