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Conference Paper: Effect of donor steatosis on liver biochemistry and significance of body mass index and alanine aminotransferase in predicting steatosis

TitleEffect of donor steatosis on liver biochemistry and significance of body mass index and alanine aminotransferase in predicting steatosis
Authors
KeywordsMedical sciences
Endocrinology
Issue Date2011
PublisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0
Citation
The 21st Conferece of the Asian Pacific Association for the Study of the Liver (APASL 2011), Bangkok, Thailand, 17-20 February 2011. In Hepatology International, 2011, v. 5 n. 1, p. 489, abstract PP38-17 How to Cite?
AbstractBACKGROUND: Hepatic steatosis in living-donor liver transplantation is a major concern on donor safety and graft function. METHODS: Data of 329 Asian donors who underwent right hepatectomy were analyzed. The donors were categorized as having no steatosis (G0, n = 178), <10% steatosis (G1, n = 128), and >10% (G2, n = 19) steatosis. Pattern of change and factors affecting aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, and prothrombin time on days 1 to 7 and day 30 were assessed. Factors predicting steatosis were also assessed. RESULTS: A rise in ALT level was noted till day 3 in G1 and day 6 in G2 compared with G0 (p < 0.05). AST levels were different till day 7 in G2 but similar in G1 (p < 0.05). Bilirubin level was higher only in day 1 in G2 (p < 0.05). On multivariate analysis, apart from fatty change, body mass index (BMI) and remnant left lobe volume showed a significant correlation with ALT levels (p < 0.05). By day 30, the median level of enzymes and number of patients having levels above the reference range were similar (p > 0.05). Receiver operating characteristic area under the curve (AOC) for BMI on predicting steatosis was 0.75 (CI = 69–80). Seventy-five percent of patients in the fourth quartile of BMI (23.5–29 kg/m2) had steatosis. Seventy percent of G2 were in this category. In patients with BMI over 23.5 kg/m2, multivariate analysis showed a significant correlation between ALT and steatosis (p = 0.05, OR = 1.14, CI = 1–1.3). ALT level < 17.5 µL predicted steatosis with 66% sensitivity (CI = 52–77) and 78% (CI = 52–92) specificity (AOC -0.71, CI = 56–85). CONCLUSIONS: Donors showed a short-lasting rise in ALT, AST and bilirubin level dependent on the degree of steatosis. For Asian donors, an ALT level above 17.5 µL and a BMI above 23.5 kg/m2 are useful guides in the decision on liver biopsy.
Descriptionpp. 3-558 of this journal issue contain Abstracts of the 21st APASL Conference 2011
Persistent Identifierhttp://hdl.handle.net/10722/136100
ISSN
2015 Impact Factor: 1.125
2015 SCImago Journal Rankings: 0.669
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSiriwardana, RCen_US
dc.contributor.authorChan, SCen_US
dc.contributor.authorLo, CMen_US
dc.contributor.authorChok, KSHen_US
dc.contributor.authorFan, STen_US
dc.date.accessioned2011-07-27T02:02:50Z-
dc.date.available2011-07-27T02:02:50Z-
dc.date.issued2011en_US
dc.identifier.citationThe 21st Conferece of the Asian Pacific Association for the Study of the Liver (APASL 2011), Bangkok, Thailand, 17-20 February 2011. In Hepatology International, 2011, v. 5 n. 1, p. 489, abstract PP38-17en_US
dc.identifier.issn1936-0533-
dc.identifier.urihttp://hdl.handle.net/10722/136100-
dc.descriptionpp. 3-558 of this journal issue contain Abstracts of the 21st APASL Conference 2011-
dc.description.abstractBACKGROUND: Hepatic steatosis in living-donor liver transplantation is a major concern on donor safety and graft function. METHODS: Data of 329 Asian donors who underwent right hepatectomy were analyzed. The donors were categorized as having no steatosis (G0, n = 178), <10% steatosis (G1, n = 128), and >10% (G2, n = 19) steatosis. Pattern of change and factors affecting aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, and prothrombin time on days 1 to 7 and day 30 were assessed. Factors predicting steatosis were also assessed. RESULTS: A rise in ALT level was noted till day 3 in G1 and day 6 in G2 compared with G0 (p < 0.05). AST levels were different till day 7 in G2 but similar in G1 (p < 0.05). Bilirubin level was higher only in day 1 in G2 (p < 0.05). On multivariate analysis, apart from fatty change, body mass index (BMI) and remnant left lobe volume showed a significant correlation with ALT levels (p < 0.05). By day 30, the median level of enzymes and number of patients having levels above the reference range were similar (p > 0.05). Receiver operating characteristic area under the curve (AOC) for BMI on predicting steatosis was 0.75 (CI = 69–80). Seventy-five percent of patients in the fourth quartile of BMI (23.5–29 kg/m2) had steatosis. Seventy percent of G2 were in this category. In patients with BMI over 23.5 kg/m2, multivariate analysis showed a significant correlation between ALT and steatosis (p = 0.05, OR = 1.14, CI = 1–1.3). ALT level < 17.5 µL predicted steatosis with 66% sensitivity (CI = 52–77) and 78% (CI = 52–92) specificity (AOC -0.71, CI = 56–85). CONCLUSIONS: Donors showed a short-lasting rise in ALT, AST and bilirubin level dependent on the degree of steatosis. For Asian donors, an ALT level above 17.5 µL and a BMI above 23.5 kg/m2 are useful guides in the decision on liver biopsy.-
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0-
dc.relation.ispartofHepatology Internationalen_US
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectMedical sciences-
dc.subjectEndocrinology-
dc.titleEffect of donor steatosis on liver biochemistry and significance of body mass index and alanine aminotransferase in predicting steatosisen_US
dc.typeConference_Paperen_US
dc.identifier.emailSiriwardana, RC: rohan@hku.hken_US
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.authorityChan, SC=rp01568en_US
dc.identifier.authorityLo, CM=rp00412en_US
dc.identifier.doi10.1007/s12072-010-9241-z-
dc.identifier.hkuros188358en_US
dc.identifier.volume5en_US
dc.identifier.issue1-
dc.identifier.spage489en_US
dc.identifier.epage489en_US
dc.identifier.isiWOS:000300105300001-
dc.publisher.placeUnited States-
dc.description.otherThe 21st Conferece of the Asian Pacific Association for the Study of the Liver (APASL 2011), Bangkok, Thailand, 17-20 February 2011. In Hepatology International, 2011, v. 5 n. 1, p. 489, abstract PP38-17-

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