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Conference Paper: Rapid measurement of indocyanine green clearance by pulse spectrophotometry: a validation study in 70 patients with Child-pugh A liver function

TitleRapid measurement of indocyanine green clearance by pulse spectrophotometry: a validation study in 70 patients with Child-pugh A liver function
Authors
KeywordsMedical sciences
Endocrinology
Issue Date2011
PublisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0
Citation
The 21st Conferece of the Asian Pacific Association for the Study of the Liver (APASL 2011), Bangkok, Thailand, 17-20 February 2011. In Hepatology International, 2011, v. 5 n. 1, p. 464, abstract PP34-21 How to Cite?
AbstractBACKGROUND: Inadequate liver functional reserve is the greatest barrier for major hepatectomy in patients with hepatocellular carcinoma and liver cirrhosis. The development of pulse spectrophotometry provides a faster alternative for ICG measurement but its accuracy in for preoperative assessment is not well documented as most of the previous studies consisted of a heterogenous group of patients in the critically ill patients. This study compared the result of non-invasive liver function monitoring using the LiMON (Pulsion Medical System, Munich, Germany) and traditional spectrophotometry by serial blood sampling in patient with Pugh Child A score before major hepatic resection. STUDY DESIGN: From September 2008 to Jan 2009, 70 patients with Pugh Child A score were enrolled for investigations. Their ICG clearance at 15 min were measured by traditional spectrophotometry with serial blood sampling and the LiMON. The results were compared. RESULTS: The median ICG retention at 15 min by spectrophotometry was 14.748%. The median ICGR15 measured by LiMON was 10.38. The mean difference between the LiMON and spectrophotometry was -4.3606. There was a strong correlation between the 2 measurement methods (correlation coefficient 0.844, 95% CI = 0.762, 0.899). The ICGR15 measured by LiMON, the ICG15 measured by traditional method can be calculated using the following formula. ICG15 = 1.16 * ICGR15 + 2.73 Conclusions: The LiMON is a portable unit which provides a fast and repeatable method to evaluate the ICG clearance at 15 min for patient with Pugh Child A Score. Adjustment of result is necessary in order to achieve a comparable result obtained by spectrophotometry.
Descriptionpp. 3-558 of this journal issue contain Abstracts of the 21st APASL Conference 2011
Persistent Identifierhttp://hdl.handle.net/10722/136097
ISSN
2014 Impact Factor: 1.780
2014 SCImago Journal Rankings: 0.609
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, TTen_US
dc.contributor.authorChan, SCen_US
dc.contributor.authorPoon, RTPen_US
dc.contributor.authorLo, CMen_US
dc.contributor.authorFan, STen_US
dc.date.accessioned2011-07-27T02:02:46Z-
dc.date.available2011-07-27T02:02:46Z-
dc.date.issued2011en_US
dc.identifier.citationThe 21st Conferece of the Asian Pacific Association for the Study of the Liver (APASL 2011), Bangkok, Thailand, 17-20 February 2011. In Hepatology International, 2011, v. 5 n. 1, p. 464, abstract PP34-21en_US
dc.identifier.issn1936-0533-
dc.identifier.urihttp://hdl.handle.net/10722/136097-
dc.descriptionpp. 3-558 of this journal issue contain Abstracts of the 21st APASL Conference 2011-
dc.description.abstractBACKGROUND: Inadequate liver functional reserve is the greatest barrier for major hepatectomy in patients with hepatocellular carcinoma and liver cirrhosis. The development of pulse spectrophotometry provides a faster alternative for ICG measurement but its accuracy in for preoperative assessment is not well documented as most of the previous studies consisted of a heterogenous group of patients in the critically ill patients. This study compared the result of non-invasive liver function monitoring using the LiMON (Pulsion Medical System, Munich, Germany) and traditional spectrophotometry by serial blood sampling in patient with Pugh Child A score before major hepatic resection. STUDY DESIGN: From September 2008 to Jan 2009, 70 patients with Pugh Child A score were enrolled for investigations. Their ICG clearance at 15 min were measured by traditional spectrophotometry with serial blood sampling and the LiMON. The results were compared. RESULTS: The median ICG retention at 15 min by spectrophotometry was 14.748%. The median ICGR15 measured by LiMON was 10.38. The mean difference between the LiMON and spectrophotometry was -4.3606. There was a strong correlation between the 2 measurement methods (correlation coefficient 0.844, 95% CI = 0.762, 0.899). The ICGR15 measured by LiMON, the ICG15 measured by traditional method can be calculated using the following formula. ICG15 = 1.16 * ICGR15 + 2.73 Conclusions: The LiMON is a portable unit which provides a fast and repeatable method to evaluate the ICG clearance at 15 min for patient with Pugh Child A Score. Adjustment of result is necessary in order to achieve a comparable result obtained by spectrophotometry.-
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0-
dc.relation.ispartofHepatology Internationalen_US
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectMedical sciences-
dc.subjectEndocrinology-
dc.titleRapid measurement of indocyanine green clearance by pulse spectrophotometry: a validation study in 70 patients with Child-pugh A liver functionen_US
dc.typeConference_Paperen_US
dc.identifier.emailCheung, TT: cheung68@hku.hken_US
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_US
dc.identifier.emailPoon, RTP: poontp@hku.hken_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.authorityChan, SC=rp01568en_US
dc.identifier.authorityPoon, RTP=rp00446en_US
dc.identifier.authorityLo, CM=rp00412en_US
dc.identifier.doi10.1007/s12072-010-9241-z-
dc.identifier.hkuros188347en_US
dc.identifier.volume5en_US
dc.identifier.issue1-
dc.identifier.spage464en_US
dc.identifier.epage464en_US
dc.identifier.isiWOS:000300105300001-
dc.publisher.placeUnited States-
dc.description.otherThe 21st Conferece of the Asian Pacific Association for the Study of the Liver (APASL 2011), Bangkok, Thailand, 17-20 February 2011. In Hepatology International, 2011, v. 5 n. 1, p. 464, abstract PP34-21-

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