Conference Paper: Rapid measurement of indocyanine green clearance by pulse spectrophotometry: a validation study in 70 patients with Child-pugh A liver function
| Title | Rapid measurement of indocyanine green clearance by pulse spectrophotometry: a validation study in 70 patients with Child-pugh A liver function |
|---|---|
| Authors | Cheung, TT Chan, SC Poon, RTP Lo, CM Fan, ST |
| Keywords | Medical sciences Endocrinology |
| Issue Date | 2011 |
| Publisher | Springer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0 |
| Citation | The 21st Conferece of the Asian Pacific Association for the Study of the Liver (APASL 2011), Bangkok, Thailand, 17-20 February 2011. In Hepatology International, 2011, v. 5 n. 1, p. 464, abstract PP34-21 [How to Cite?] DOI: http://dx.doi.org/10.1007/s12072-010-9241-z |
| Abstract | BACKGROUND: Inadequate liver functional reserve is the greatest barrier for major hepatectomy in patients with hepatocellular carcinoma and liver cirrhosis. The development of pulse spectrophotometry provides a faster alternative for ICG measurement but its accuracy in for preoperative assessment is not well documented as most of the previous studies consisted of a heterogenous group of patients in the critically ill patients. This study compared the result of non-invasive liver function monitoring using the LiMON (Pulsion Medical System, Munich, Germany) and traditional spectrophotometry by serial blood sampling in patient with Pugh Child A score before major hepatic resection. STUDY DESIGN: From September 2008 to Jan 2009, 70 patients with Pugh Child A score were enrolled for investigations. Their ICG clearance at 15 min were measured by traditional spectrophotometry with serial blood sampling and the LiMON. The results were compared. RESULTS: The median ICG retention at 15 min by spectrophotometry was 14.748%. The median ICGR15 measured by LiMON was 10.38. The mean difference between the LiMON and spectrophotometry was -4.3606. There was a strong correlation between the 2 measurement methods (correlation coefficient 0.844, 95% CI = 0.762, 0.899). The ICGR15 measured by LiMON, the ICG15 measured by traditional method can be calculated using the following formula. ICG15 = 1.16 * ICGR15 + 2.73 Conclusions: The LiMON is a portable unit which provides a fast and repeatable method to evaluate the ICG clearance at 15 min for patient with Pugh Child A Score. Adjustment of result is necessary in order to achieve a comparable result obtained by spectrophotometry. |
| Description | pp. 3-558 of this journal issue contain Abstracts of the 21st APASL Conference 2011 |
| ISSN | 1936-0533 2011 Impact Factor: 2.645 2011 SCImago Journal Rankings: 0.244 |
| DOI | http://dx.doi.org/10.1007/s12072-010-9241-z |
| dc.contributor.author | Cheung, TT |
|---|---|
| dc.contributor.author | Chan, SC |
| dc.contributor.author | Poon, RTP |
| dc.contributor.author | Lo, CM |
| dc.contributor.author | Fan, ST |
| dc.date.accessioned | 2011-07-27T02:02:46Z |
| dc.date.available | 2011-07-27T02:02:46Z |
| dc.date.issued | 2011 |
| dc.description.abstract | BACKGROUND: Inadequate liver functional reserve is the greatest barrier for major hepatectomy in patients with hepatocellular carcinoma and liver cirrhosis. The development of pulse spectrophotometry provides a faster alternative for ICG measurement but its accuracy in for preoperative assessment is not well documented as most of the previous studies consisted of a heterogenous group of patients in the critically ill patients. This study compared the result of non-invasive liver function monitoring using the LiMON (Pulsion Medical System, Munich, Germany) and traditional spectrophotometry by serial blood sampling in patient with Pugh Child A score before major hepatic resection. STUDY DESIGN: From September 2008 to Jan 2009, 70 patients with Pugh Child A score were enrolled for investigations. Their ICG clearance at 15 min were measured by traditional spectrophotometry with serial blood sampling and the LiMON. The results were compared. RESULTS: The median ICG retention at 15 min by spectrophotometry was 14.748%. The median ICGR15 measured by LiMON was 10.38. The mean difference between the LiMON and spectrophotometry was -4.3606. There was a strong correlation between the 2 measurement methods (correlation coefficient 0.844, 95% CI = 0.762, 0.899). The ICGR15 measured by LiMON, the ICG15 measured by traditional method can be calculated using the following formula. ICG15 = 1.16 * ICGR15 + 2.73 Conclusions: The LiMON is a portable unit which provides a fast and repeatable method to evaluate the ICG clearance at 15 min for patient with Pugh Child A Score. Adjustment of result is necessary in order to achieve a comparable result obtained by spectrophotometry. |
| dc.description | pp. 3-558 of this journal issue contain Abstracts of the 21st APASL Conference 2011 |
| dc.description.other | The 21st Conferece of the Asian Pacific Association for the Study of the Liver (APASL 2011), Bangkok, Thailand, 17-20 February 2011. In Hepatology International, 2011, v. 5 n. 1, p. 464, abstract PP34-21 |
| dc.identifier.citation | The 21st Conferece of the Asian Pacific Association for the Study of the Liver (APASL 2011), Bangkok, Thailand, 17-20 February 2011. In Hepatology International, 2011, v. 5 n. 1, p. 464, abstract PP34-21 [How to Cite?] DOI: http://dx.doi.org/10.1007/s12072-010-9241-z |
| dc.identifier.doi | http://dx.doi.org/10.1007/s12072-010-9241-z |
| dc.identifier.epage | 464 |
| dc.identifier.hkuros | 188347 |
| dc.identifier.issn | 1936-0533 2011 Impact Factor: 2.645 2011 SCImago Journal Rankings: 0.244 |
| dc.identifier.issue | 1 |
| dc.identifier.spage | 464 |
| dc.identifier.uri | http://hdl.handle.net/10722/136097 |
| dc.identifier.volume | 5 |
| dc.language | eng |
| dc.publisher | Springer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0 |
| dc.publisher.place | United States |
| dc.relation.ispartof | Hepatology International |
| dc.rights | The original publication is available at www.springerlink.com |
| dc.subject | Medical sciences |
| dc.subject | Endocrinology |
| dc.title | Rapid measurement of indocyanine green clearance by pulse spectrophotometry: a validation study in 70 patients with Child-pugh A liver function |
| dc.type | Conference_Paper |