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Conference Paper: Subclinical left ventricular dysfunction revealed by circumferential 2D strain imaging in coronary artery disease patients with ECG fragmented QRS complex

TitleSubclinical left ventricular dysfunction revealed by circumferential 2D strain imaging in coronary artery disease patients with ECG fragmented QRS complex
Authors
KeywordsCoronary heart disease
Echocardiography
Strain rate
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org
Citation
The 2011 Scientific Sessions of the American Heart Association (AHA), Orlando, FL., 12-16 November 2011. In Circulation, 2011, v. 124 n. 21 suppl., abstract 15016 How to Cite?
AbstractBACKGROUND: Fragmented QRS complexes (fQRS) on a routine 12-lead electrocardiogram, a marker of depolarization abnormality, are associated with adverse cardiac events, including sudden death in patients with coronary artery disease (CAD). METHODS & RESULTS: We investigated the relationships between fQRS with global and regional left ventricular (LV) function in 176 CAD patients (pts, 68±9 year, 145 men) with narrow QRS duration and preserved LV ejection fraction (LVEF,>45%). Detailed 2D speckle-tracking echocardiography was performed to determine global and segmental(basal, middle and apical) LV circumferential strains and strain rates. fQRS was detected in 55(31%) of CAD pts. There were no significant differences in the clinical demographic features and medications between pts with (fQRS gp) and without fQRS (non-fQRS gp). However, wall motion score index (1.26±0.44 vs. 1.10±0.23, P=0.002) and the prevalence of multi-vessel disease (73% vs. 48%, P=0.003) were significantly higher and LVEF were lower (52 vs. 59%, P<0.01) in fQRS gp as compared with non-fQRS gp. Global circumferential strain and strain rate were significantly reduced in fQRS gp compared with non-fQRS gp (Table 1, all P<0.05). Furthermore, segmental circumferential strain and strain rate over apical LV was also decreased in fQRS gp compared with non-fQRS gp (Table 1, all P<0.01). Multivariate linear regression analysis showed that decreased global circumferential strain (Odd ratio [OR] 1.19, 95% confidence interval [CI] 1.06-1.33, P=0.003) and multivessel disease (OR 3.69, 95% CI 1.35-10.08, P=0.011) were predictors for fQRS independent regional wall motion abnormality and LVEF. CONCLUSION: Our results demonstrated that 2D circumferential strain imaging revealed subclinical LV dysfunction in CAD pts with fQRS complex on resting ECG, which may contribute to ventricular depolarization abnormalities and adverse clinical outcomes.
DescriptionCore 1. Cardiovascular Imaging
Session: Echocardiography: Evaluation of Systolic Function-Roles of Strain 2: abstract 15016
Persistent Identifierhttp://hdl.handle.net/10722/135903
ISSN
2015 Impact Factor: 17.047
2015 SCImago Journal Rankings: 7.853

 

DC FieldValueLanguage
dc.contributor.authorYan, Gen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorZhi, Gen_US
dc.contributor.authorYiu, KHen_US
dc.contributor.authorLau, CPen_US
dc.contributor.authorLee, SWLen_US
dc.contributor.authorSiu, CWen_US
dc.contributor.authorTse, HFen_US
dc.date.accessioned2011-07-27T01:59:30Z-
dc.date.available2011-07-27T01:59:30Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 Scientific Sessions of the American Heart Association (AHA), Orlando, FL., 12-16 November 2011. In Circulation, 2011, v. 124 n. 21 suppl., abstract 15016en_US
dc.identifier.issn0009-7322-
dc.identifier.urihttp://hdl.handle.net/10722/135903-
dc.descriptionCore 1. Cardiovascular Imaging-
dc.descriptionSession: Echocardiography: Evaluation of Systolic Function-Roles of Strain 2: abstract 15016-
dc.description.abstractBACKGROUND: Fragmented QRS complexes (fQRS) on a routine 12-lead electrocardiogram, a marker of depolarization abnormality, are associated with adverse cardiac events, including sudden death in patients with coronary artery disease (CAD). METHODS & RESULTS: We investigated the relationships between fQRS with global and regional left ventricular (LV) function in 176 CAD patients (pts, 68±9 year, 145 men) with narrow QRS duration and preserved LV ejection fraction (LVEF,>45%). Detailed 2D speckle-tracking echocardiography was performed to determine global and segmental(basal, middle and apical) LV circumferential strains and strain rates. fQRS was detected in 55(31%) of CAD pts. There were no significant differences in the clinical demographic features and medications between pts with (fQRS gp) and without fQRS (non-fQRS gp). However, wall motion score index (1.26±0.44 vs. 1.10±0.23, P=0.002) and the prevalence of multi-vessel disease (73% vs. 48%, P=0.003) were significantly higher and LVEF were lower (52 vs. 59%, P<0.01) in fQRS gp as compared with non-fQRS gp. Global circumferential strain and strain rate were significantly reduced in fQRS gp compared with non-fQRS gp (Table 1, all P<0.05). Furthermore, segmental circumferential strain and strain rate over apical LV was also decreased in fQRS gp compared with non-fQRS gp (Table 1, all P<0.01). Multivariate linear regression analysis showed that decreased global circumferential strain (Odd ratio [OR] 1.19, 95% confidence interval [CI] 1.06-1.33, P=0.003) and multivessel disease (OR 3.69, 95% CI 1.35-10.08, P=0.011) were predictors for fQRS independent regional wall motion abnormality and LVEF. CONCLUSION: Our results demonstrated that 2D circumferential strain imaging revealed subclinical LV dysfunction in CAD pts with fQRS complex on resting ECG, which may contribute to ventricular depolarization abnormalities and adverse clinical outcomes.-
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org-
dc.relation.ispartofCirculationen_US
dc.subjectCoronary heart disease-
dc.subjectEchocardiography-
dc.subjectStrain rate-
dc.titleSubclinical left ventricular dysfunction revealed by circumferential 2D strain imaging in coronary artery disease patients with ECG fragmented QRS complexen_US
dc.typeConference_Paperen_US
dc.identifier.emailYan, G: guohui@hkucc.hku.hken_US
dc.identifier.emailWang, M: meiwang@hkucc.hku.hken_US
dc.identifier.emailYiu, KH: khkyiu@hku.hken_US
dc.identifier.emailLau, CP: cplau@hku.hken_US
dc.identifier.emailLee, SWL: drsl@hkucc.hku.hken_US
dc.identifier.emailSiu, CW: cwdsiu@hkucc.hku.hken_US
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_US
dc.identifier.authorityWang, M=rp00281en_US
dc.identifier.authorityYiu, KH=rp01490en_US
dc.identifier.authoritySiu, CW=rp00534en_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.identifier.hkuros187161en_US
dc.identifier.volume124-
dc.identifier.issue21 meeting abstracts-
dc.publisher.placeUnited States-

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