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Conference Paper: Brain activations of deglutition in normal adult humans - fMRI study
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TitleBrain activations of deglutition in normal adult humans - fMRI study
 
AuthorsGoto, T
Nakamura, Y
Kawasaki, T
Tokumor, K
Kobayashi, K
Yoshiura, T
Nakamura, Y
Honda, H
Yoshimura, K
 
KeywordsFunction
Human
Magnetic Resonance Imaging
Deglutition
 
Issue Date2010
 
PublisherInternational Association of Dental Research (IADR).
 
CitationThe 88th General Session & Exhibition of the International Association of Dental Research (IADR), Barcelone, Spain, 14-17 July 2010. [How to Cite?]
 
AbstractOBJECTIVES: The purpose of this study was to explore the brain activation of volitional deglutition in normal adult humans using functional MRI (fMRI). METHODS: Six healthy young adults (three females and three males, 27-31 yrs of age, right-handed, non-smokers) participated in this study. The Human Experimentation Committee of Kyushu University approved all experimental procedures. The participants underwent MRI in a 3T scanner, and functional EPI images and three-dimensional anatomical images were acquired. In the experiment, small volume of tasteless artificial saliva (25 mM KCl plus 2.5 mM NaHCO3) was delivered 32 times through original intra-oral and computer-controlled extra-oral devices. The participants swallowed the artificial saliva at the timing of tone signals. Data analysis was performed using the Statistical Parametric Mapping 8 software (WTCN, London, UK). To remove the artifacts by the head movements of the participants during deglutition, the images were realigned, and then the estimated movement parameters were included as covariates in the design matrix. First, the activation of each subject was investigated and anatomically identified on her/his own brain anatomy. Second, each individual data set was entered into the group analysis (conjunction analysis) to infer the typical characteristics of the participants. RESULTS: Multiple regions of highly significant activations were obtained with the volitional deglutition (p < 0.05 Family Wise Error corrected). Those activation foci were located in the pre- and postcentral gyri (the primary motor and somatosensory cortices, respectively), the anterior cingulated cortex (corresponding to affective/attentive reactions), the insula (sensory-motor integration), as well as in areas of the thalamus (relay station for sensory information) and the cerebellum (adaptive modulation). CONCLUSION: The brain activities of deglutition were represented in many of the spatially and functionally distinct cortical regions which work differently in the regulation of deglutition.
 
DescriptionSession 8 - Computed Tomography and Magnetic Resonance Imaging: abstract no. 31
 
DC FieldValue
dc.contributor.authorGoto, T
 
dc.contributor.authorNakamura, Y
 
dc.contributor.authorKawasaki, T
 
dc.contributor.authorTokumor, K
 
dc.contributor.authorKobayashi, K
 
dc.contributor.authorYoshiura, T
 
dc.contributor.authorNakamura, Y
 
dc.contributor.authorHonda, H
 
dc.contributor.authorYoshimura, K
 
dc.date.accessioned2011-07-27T01:47:36Z
 
dc.date.available2011-07-27T01:47:36Z
 
dc.date.issued2010
 
dc.description.abstractOBJECTIVES: The purpose of this study was to explore the brain activation of volitional deglutition in normal adult humans using functional MRI (fMRI). METHODS: Six healthy young adults (three females and three males, 27-31 yrs of age, right-handed, non-smokers) participated in this study. The Human Experimentation Committee of Kyushu University approved all experimental procedures. The participants underwent MRI in a 3T scanner, and functional EPI images and three-dimensional anatomical images were acquired. In the experiment, small volume of tasteless artificial saliva (25 mM KCl plus 2.5 mM NaHCO3) was delivered 32 times through original intra-oral and computer-controlled extra-oral devices. The participants swallowed the artificial saliva at the timing of tone signals. Data analysis was performed using the Statistical Parametric Mapping 8 software (WTCN, London, UK). To remove the artifacts by the head movements of the participants during deglutition, the images were realigned, and then the estimated movement parameters were included as covariates in the design matrix. First, the activation of each subject was investigated and anatomically identified on her/his own brain anatomy. Second, each individual data set was entered into the group analysis (conjunction analysis) to infer the typical characteristics of the participants. RESULTS: Multiple regions of highly significant activations were obtained with the volitional deglutition (p < 0.05 Family Wise Error corrected). Those activation foci were located in the pre- and postcentral gyri (the primary motor and somatosensory cortices, respectively), the anterior cingulated cortex (corresponding to affective/attentive reactions), the insula (sensory-motor integration), as well as in areas of the thalamus (relay station for sensory information) and the cerebellum (adaptive modulation). CONCLUSION: The brain activities of deglutition were represented in many of the spatially and functionally distinct cortical regions which work differently in the regulation of deglutition.
 
dc.description.naturelink_to_OA_fulltext
 
dc.descriptionSession 8 - Computed Tomography and Magnetic Resonance Imaging: abstract no. 31
 
dc.identifier.citationThe 88th General Session & Exhibition of the International Association of Dental Research (IADR), Barcelone, Spain, 14-17 July 2010. [How to Cite?]
 
dc.identifier.hkuros186179
 
dc.identifier.urihttp://hdl.handle.net/10722/135734
 
dc.languageeng
 
dc.publisherInternational Association of Dental Research (IADR).
 
dc.publisher.placeUnited States
 
dc.relation.ispartof88th IADR General Session, 2010
 
dc.subjectFunction
 
dc.subjectHuman
 
dc.subjectMagnetic Resonance Imaging
 
dc.subjectDeglutition
 
dc.titleBrain activations of deglutition in normal adult humans - fMRI study
 
dc.typeConference_Paper
 
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<item><contributor.author>Goto, T</contributor.author>
<contributor.author>Nakamura, Y</contributor.author>
<contributor.author>Kawasaki, T</contributor.author>
<contributor.author>Tokumor, K</contributor.author>
<contributor.author>Kobayashi, K</contributor.author>
<contributor.author>Yoshiura, T</contributor.author>
<contributor.author>Nakamura, Y</contributor.author>
<contributor.author>Honda, H</contributor.author>
<contributor.author>Yoshimura, K</contributor.author>
<date.accessioned>2011-07-27T01:47:36Z</date.accessioned>
<date.available>2011-07-27T01:47:36Z</date.available>
<date.issued>2010</date.issued>
<identifier.citation>The 88th General Session &amp; Exhibition of the International Association of Dental Research (IADR), Barcelone, Spain, 14-17 July 2010.</identifier.citation>
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<description.abstract>OBJECTIVES: The purpose of this study was to explore the brain activation of volitional deglutition in normal adult humans using functional MRI (fMRI). METHODS: Six healthy young adults (three females and three males, 27-31 yrs of age, right-handed, non-smokers) participated in this study. The Human Experimentation Committee of Kyushu University approved all experimental procedures. The participants underwent MRI in a 3T scanner, and functional EPI images and three-dimensional anatomical images were acquired. In the experiment, small volume of tasteless artificial saliva (25 mM KCl plus 2.5 mM NaHCO3) was delivered 32 times through original intra-oral and computer-controlled extra-oral devices. The participants swallowed the artificial saliva at the timing of tone signals. Data analysis was performed using the Statistical Parametric Mapping 8 software (WTCN, London, UK). To remove the artifacts by the head movements of the participants during deglutition, the images were realigned, and then the estimated movement parameters were included as covariates in the design matrix. First, the activation of each subject was investigated and anatomically identified on her/his own brain anatomy. Second, each individual data set was entered into the group analysis (conjunction analysis) to infer the typical characteristics of the participants. RESULTS: Multiple regions of highly significant activations were obtained with the volitional deglutition (p &lt; 0.05 Family Wise Error corrected). Those activation foci were located in the pre- and postcentral gyri (the primary motor and somatosensory cortices, respectively), the anterior cingulated cortex (corresponding to affective/attentive reactions), the insula (sensory-motor integration), as well as in areas of the thalamus (relay station for sensory information) and the cerebellum (adaptive modulation). CONCLUSION: The brain activities of deglutition were represented in many of the spatially and functionally distinct cortical regions which work differently in the regulation of deglutition.</description.abstract>
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<subject>Function</subject>
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