Conference Paper: Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva

TitleTropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva
Authors
Keywords2009 pandemic H1N1 influenza virus
Conjunctiva
Swine influenza virus
Tropism
Innate host responses
Issue Date2011
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/subs.asp?ref=1750-2640&site=1
Citation
The 2010 International Scientific Conference of Options for the Control of Influenza (Options-7), Hong Kong SAR, China, 3-7 September 2010. In Influenza and Other Respiratory Viruses, 2011, v. 5 suppl. s1, p. 54-55 How to Cite?
AbstractBACKGROUND: Pandemic influenza H1N1 (H1N1pdm) virus of swine-origin causes mild disease, but occasionally is associated with acute respiratory distress syndrome and death.1,2 It is important to understand the pathogenesis of this new disease. Previously we showed a comparable virus tropism and host innate immune responses between H1N1pdm and seasonal H1N1 influenza virus in the human respiratory tract,3 however H1N1pdm virus differed from seasonal H1N1 influenza virus in its ability to replicate in human conjunctiva, suggesting subtle differences in receptor-binding profile and highlighting the potential role of the conjunctiva as an additional route of infection. We now compare the tropism and host responses elicited by pandemic H1N1 with that of related swine influenza viruses and a pandemic-swine reassortant virus in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva. We have used recombinant virus to investigate the role of the hemagglutinin (HA) and neuraminidase (NA) of H1N1pdm virus in its conjunctival tropism. These findings are relevant for understanding transmission and therapy …
Persistent Identifierhttp://hdl.handle.net/10722/135687
ISSN
2015 Impact Factor: 2.378
2015 SCImago Journal Rankings: 1.570

 

DC FieldValueLanguage
dc.contributor.authorChan, MCWen_US
dc.contributor.authorChan, RWYen_US
dc.contributor.authorYen, HLen_US
dc.contributor.authorYu, WCLen_US
dc.contributor.authorYuen, KMen_US
dc.contributor.authorTang, LLSen_US
dc.contributor.authorLi, ACLen_US
dc.contributor.authorKang, SSRen_US
dc.contributor.authorHui, CFFen_US
dc.contributor.authorLai, WWKen_US
dc.contributor.authorSihoe, ADLen_US
dc.contributor.authorGuan, Yen_US
dc.contributor.authorNicholls, JMen_US
dc.contributor.authorPeiris, JSMen_US
dc.date.accessioned2011-07-27T01:39:26Z-
dc.date.available2011-07-27T01:39:26Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2010 International Scientific Conference of Options for the Control of Influenza (Options-7), Hong Kong SAR, China, 3-7 September 2010. In Influenza and Other Respiratory Viruses, 2011, v. 5 suppl. s1, p. 54-55en_US
dc.identifier.issn1750-2640-
dc.identifier.urihttp://hdl.handle.net/10722/135687-
dc.description.abstractBACKGROUND: Pandemic influenza H1N1 (H1N1pdm) virus of swine-origin causes mild disease, but occasionally is associated with acute respiratory distress syndrome and death.1,2 It is important to understand the pathogenesis of this new disease. Previously we showed a comparable virus tropism and host innate immune responses between H1N1pdm and seasonal H1N1 influenza virus in the human respiratory tract,3 however H1N1pdm virus differed from seasonal H1N1 influenza virus in its ability to replicate in human conjunctiva, suggesting subtle differences in receptor-binding profile and highlighting the potential role of the conjunctiva as an additional route of infection. We now compare the tropism and host responses elicited by pandemic H1N1 with that of related swine influenza viruses and a pandemic-swine reassortant virus in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva. We have used recombinant virus to investigate the role of the hemagglutinin (HA) and neuraminidase (NA) of H1N1pdm virus in its conjunctival tropism. These findings are relevant for understanding transmission and therapy …-
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/subs.asp?ref=1750-2640&site=1-
dc.relation.ispartofInfluenza and Other Respiratory Virusesen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject2009 pandemic H1N1 influenza virus-
dc.subjectConjunctiva-
dc.subjectSwine influenza virus-
dc.subjectTropism-
dc.subjectInnate host responses-
dc.titleTropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctivaen_US
dc.typeConference_Paperen_US
dc.identifier.emailChan, MCW: mchan@hku.hken_US
dc.identifier.emailChan, RWY: reneewy@hku.hken_US
dc.identifier.emailYen, HL: hyen@hku.hken_US
dc.identifier.emailYu, WCL: wendyucl@hkucc.hku.hken_US
dc.identifier.emailTang, LLS: lynsia@hku.hken_US
dc.identifier.emailLi, ACL: alancl@hku.hken_US
dc.identifier.emailKang, SSR: sarakang@hku.hken_US
dc.identifier.emailHui, CFF: celineh@hku.hken_US
dc.identifier.emailLai, WWK: wicolai@hku.hken_US
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_US
dc.identifier.emailNicholls, JM: jmnichol@hkucc.hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityChan, MCW=rp00420en_US
dc.identifier.authorityChan, RWY=rp01596en_US
dc.identifier.authorityYen, HL=rp00304en_US
dc.identifier.authorityLai, WWK=rp00531en_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.identifier.authorityNicholls, JM=rp00364en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1750-2659.2011.00209.x-
dc.identifier.hkuros187329en_US
dc.identifier.hkuros170679-
dc.identifier.volume5en_US
dc.identifier.issuesuppl. s1en_US
dc.identifier.spage54en_US
dc.identifier.epage55en_US
dc.publisher.placeUnited Kingdom-

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