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Conference Paper: Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cells: an in vitro and ex vivo study

TitleDifferential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cells: an in vitro and ex vivo study
Authors
KeywordsAlveolar epithelial cells
Apoptosis
Avian influenza H5N1 virus
Bronchial epithelial cells
Pathogenesis
Issue Date2011
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/subs.asp?ref=1750-2640&site=1
Citation
The 2010 International Scientific Conference of Options for the Control of Influenza (Options-7), Hong Kong SAR, China, 3-7 September 2010. In Influenza and Other Respiratory Viruses, 2011, v. 5 suppl. 1, p. 437-438 How to Cite?
AbstractINTRODUCTION: Human disease caused by highly pathogenic avian influenza (HPAI) H5N1 virus is associated with fulminant viral pneumonia and mortality rates in excess of 60%.1 Cytokine dysregulation is thought to contribute to its pathogenesis.2,3 We previously found delayed onset of apoptosis in H5N1 infected human macrophages and, therefore, a longer survival time of the target cells for prolonged virus replication and cytokine and chemokine secretion, which may contribute to the pathogenesis of H5N1 disease in humans.4 As bronchial and alveolar epithelial cells are target cells of influenza virus because of their proximal physiological location and interaction with macrophages, we further investigated if the differential onset of apoptosis could be found in influenza H5N1 and seasonal influenza H1N1 infected human respiratory epithelia. We dissected the apoptotic pathways triggered by influenza virus infection …
Persistent Identifierhttp://hdl.handle.net/10722/135686
ISSN
2015 Impact Factor: 2.378
2015 SCImago Journal Rankings: 1.570

 

DC FieldValueLanguage
dc.contributor.authorYuen, KMen_US
dc.contributor.authorChan, RWYen_US
dc.contributor.authorMok, CKPen_US
dc.contributor.authorWong, ACNen_US
dc.contributor.authorKang, SSRen_US
dc.contributor.authorNicholls, JMen_US
dc.contributor.authorChan, MCWen_US
dc.date.accessioned2011-07-27T01:39:25Z-
dc.date.available2011-07-27T01:39:25Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2010 International Scientific Conference of Options for the Control of Influenza (Options-7), Hong Kong SAR, China, 3-7 September 2010. In Influenza and Other Respiratory Viruses, 2011, v. 5 suppl. 1, p. 437-438en_US
dc.identifier.issn1750-2640-
dc.identifier.urihttp://hdl.handle.net/10722/135686-
dc.description.abstractINTRODUCTION: Human disease caused by highly pathogenic avian influenza (HPAI) H5N1 virus is associated with fulminant viral pneumonia and mortality rates in excess of 60%.1 Cytokine dysregulation is thought to contribute to its pathogenesis.2,3 We previously found delayed onset of apoptosis in H5N1 infected human macrophages and, therefore, a longer survival time of the target cells for prolonged virus replication and cytokine and chemokine secretion, which may contribute to the pathogenesis of H5N1 disease in humans.4 As bronchial and alveolar epithelial cells are target cells of influenza virus because of their proximal physiological location and interaction with macrophages, we further investigated if the differential onset of apoptosis could be found in influenza H5N1 and seasonal influenza H1N1 infected human respiratory epithelia. We dissected the apoptotic pathways triggered by influenza virus infection …-
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/subs.asp?ref=1750-2640&site=1-
dc.relation.ispartofInfluenza and Other Respiratory Virusesen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectAlveolar epithelial cells-
dc.subjectApoptosis-
dc.subjectAvian influenza H5N1 virus-
dc.subjectBronchial epithelial cells-
dc.subjectPathogenesis-
dc.titleDifferential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cells: an in vitro and ex vivo studyen_US
dc.typeConference_Paperen_US
dc.identifier.emailChan, RWY: reneewy@hku.hken_US
dc.identifier.emailMok, CKP: ch02mkp@hkucc.hku.hken_US
dc.identifier.emailKang, SSR: sarakang@hku.hken_US
dc.identifier.emailNicholls, JM: jmnichol@hkucc.hku.hken_US
dc.identifier.emailChan, MCW: mchan@hku.hken_US
dc.identifier.authorityChan, RWY=rp01596en_US
dc.identifier.authorityNicholls, JM=rp00364en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1750-2659.2011.00209.x-
dc.identifier.hkuros187327en_US
dc.identifier.hkuros170684-
dc.identifier.volume5en_US
dc.identifier.issuesuppl. 1en_US
dc.identifier.spage437en_US
dc.identifier.epage438en_US
dc.identifier.eissn1750-2640-
dc.publisher.placeUnited Kingdom-

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