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Article: Bone loss during menopausal transition among southern Chinese women

TitleBone loss during menopausal transition among southern Chinese women
Authors
KeywordsBone loss
Chinese
Menopausal transition
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/maturitas
Citation
Maturitas, 2011, v. 69 n. 1, p. 50-56 How to Cite?
AbstractObjectives: Estrogen deficiency during menopausal transition is associated with rapid bone loss. The purpose of this study was to examine the time of onset, the rate, and predictors of menopausal bone loss. Study design: Prospective data were analyzed from 160 Chinese women between the ages of 45 to 55 years who participated in the Hong Kong Osteoporotic Study. Main outcome measures: All participants were studied yearly for 4 years. Demographic information, menstrual status according to the Stages of Reproductive Aging Workshop (STRAW), and lifestyle habits were recorded as well as bone mineral density (BMD) measured every visit. Baseline follicular stimulating hormone, sex hormone binding globulin, parathyroid hormones, C-terminal telopeptides of type 1 collagen, estradiol and testosterone were also measured. Results: There was no significant bone loss at the spine, femoral neck and total hip in premenopausal women. Maximal bone loss occurred within the STRAW stage -2 and -1. Age at menopause, baseline age, body weight and FSH were independent predictors of bone loss. Subjects in the lowest quartile of baseline body weight (<50 kg) lost bone 2 times faster at spine compared with those in the highest quartile (>61 kg). Subjects in the highest quartile of baseline FSH (>40 IU/l) lost bone 1.3-2.3 times faster at all 3 sites compared with those in the lowest quartile (<5.8 IU/l). Conclusion: Strategies to retard bone loss should be stressed to middle aged women, especially those with lean body built or with early menopause, to prevent osteoporosis later on in life. © 2011 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/135682
ISSN
2014 Impact Factor: 2.942
2013 SCImago Journal Rankings: 1.125
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

This study is funded by University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Een_HK
dc.contributor.authorTsang, Sen_HK
dc.contributor.authorBow, Cen_HK
dc.contributor.authorSoong, Cen_HK
dc.contributor.authorYeung, Sen_HK
dc.contributor.authorLoong, Cen_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorKan, Aen_HK
dc.contributor.authorLo, Sen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorTang, Gen_HK
dc.contributor.authorKung, Aen_HK
dc.date.accessioned2011-07-27T01:39:16Z-
dc.date.available2011-07-27T01:39:16Z-
dc.date.issued2011en_HK
dc.identifier.citationMaturitas, 2011, v. 69 n. 1, p. 50-56en_HK
dc.identifier.issn0378-5122en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135682-
dc.description.abstractObjectives: Estrogen deficiency during menopausal transition is associated with rapid bone loss. The purpose of this study was to examine the time of onset, the rate, and predictors of menopausal bone loss. Study design: Prospective data were analyzed from 160 Chinese women between the ages of 45 to 55 years who participated in the Hong Kong Osteoporotic Study. Main outcome measures: All participants were studied yearly for 4 years. Demographic information, menstrual status according to the Stages of Reproductive Aging Workshop (STRAW), and lifestyle habits were recorded as well as bone mineral density (BMD) measured every visit. Baseline follicular stimulating hormone, sex hormone binding globulin, parathyroid hormones, C-terminal telopeptides of type 1 collagen, estradiol and testosterone were also measured. Results: There was no significant bone loss at the spine, femoral neck and total hip in premenopausal women. Maximal bone loss occurred within the STRAW stage -2 and -1. Age at menopause, baseline age, body weight and FSH were independent predictors of bone loss. Subjects in the lowest quartile of baseline body weight (<50 kg) lost bone 2 times faster at spine compared with those in the highest quartile (>61 kg). Subjects in the highest quartile of baseline FSH (>40 IU/l) lost bone 1.3-2.3 times faster at all 3 sites compared with those in the lowest quartile (<5.8 IU/l). Conclusion: Strategies to retard bone loss should be stressed to middle aged women, especially those with lean body built or with early menopause, to prevent osteoporosis later on in life. © 2011 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/maturitasen_HK
dc.relation.ispartofMaturitasen_HK
dc.subjectBone lossen_HK
dc.subjectChineseen_HK
dc.subjectMenopausal transitionen_HK
dc.subject.meshBody Weight-
dc.subject.meshBone and Bones - pathology-
dc.subject.meshEstrogens - deficiency-
dc.subject.meshFollicle Stimulating Hormone - blood-
dc.subject.meshMenopause - physiology-
dc.titleBone loss during menopausal transition among southern Chinese womenen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, CL: lung1212@hku.hken_HK
dc.identifier.emailTang, G: gwktang@hkucc.hku.hken_HK
dc.identifier.emailKung, A: awckung@hku.hken_HK
dc.identifier.authorityCheung, CL=rp01749en_HK
dc.identifier.authorityTang, G=rp00328en_HK
dc.identifier.authorityKung, A=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.maturitas.2011.01.010en_HK
dc.identifier.pmid21310558en_HK
dc.identifier.scopuseid_2-s2.0-79954629702en_HK
dc.identifier.hkuros188343en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79954629702&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume69en_HK
dc.identifier.issue1en_HK
dc.identifier.spage50en_HK
dc.identifier.epage56en_HK
dc.identifier.isiWOS:000290889200010-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridCheung, E=9942706500en_HK
dc.identifier.scopusauthoridTsang, S=35182014900en_HK
dc.identifier.scopusauthoridBow, C=36055977600en_HK
dc.identifier.scopusauthoridSoong, C=36769165800en_HK
dc.identifier.scopusauthoridYeung, S=7102767673en_HK
dc.identifier.scopusauthoridLoong, C=36768353300en_HK
dc.identifier.scopusauthoridCheung, CL=14520953400en_HK
dc.identifier.scopusauthoridKan, A=8574836200en_HK
dc.identifier.scopusauthoridLo, S=8718876900en_HK
dc.identifier.scopusauthoridTam, S=36947522200en_HK
dc.identifier.scopusauthoridTang, G=7401633864en_HK
dc.identifier.scopusauthoridKung, A=7102322339en_HK
dc.identifier.citeulike8831947-

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