Article: Melamine-tainted milk product-associated urinary stones in children
| Title | Melamine-tainted milk product-associated urinary stones in children | ||||
|---|---|---|---|---|---|
| Authors | Wang, Z5 Luo, H5 Tu, W1 4 Yang, H5 Wong, WHS4 Wong, WT4 Yung, KF4 Zhou, N3 Zhang, J3 Li, X3 Wang, Z5 Guo, W5 Mu, D5 Li, F5 Mao, M1 2 4 5 Lau, YL4 | ||||
| Keywords | cyanuric acid melamine milk uric acid urinary stones | ||||
| Issue Date | 2011 | ||||
| Publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PED | ||||
| Citation | Pediatrics International, 2011, v. 53 n. 4, p. 489-496 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1442-200X.2010.03284.x | ||||
| Abstract | Background: An outbreak of urinary stones related to consumption of melamine-tainted milk products (MTMP) occurred in China in 2008. The aim of the present study was to evaluate such children to identify their clinical features and risk factors. Methods: Renal ultrasound was performed for 7328 children who presented to a Sichuan teaching hospital between 13 September and 15 October 2008 due to concern of such stones. Clinical data, family information, feeding history and urinary stones were analyzed. Results: Of the 7328 children, 189 (2.58%) had ultrasound findings of urinary stones, and 51 were admitted. Age (mean ± SD) was 27.4 ± 25.5 months, and 101 were male and 88, female. The odds ratio (OR) for urinary stones for infants and young children (1-3 years) as compared to older children (>3 years), was 2.42 (95% confidence interval [CI], 1.64-3.56; P < 0.0001) and 1.95 (95%CI, 1.31-2.89; P < 0.0011), respectively. Independent risk factors associated with urinary stones included consumption of MTMP with melamine at >5500 mg/kg (OR, 13.3; 95%CI, 6.8-26.1, P < 0.0001) as compared to that with melamine at <200 mg/kg, and younger father (P = 0.0006). On logistic regression, the only risk factor associated with inpatient care was lower family income per person (OR, 4.4; 95%CI, 1.2-15.9, P = 0.02). Repeat ultrasound for 51 children at mean follow up of 15.3 ± 8.9 days found that 33 passed out all stones, which was associated with a larger number of smaller stones (P = 0.003). Urinary stones contained melamine and uric acid, but no cyanuric acid. Conclusions: MTMP-associated urinary stones were more frequent in young children and more severe in children from poorer families. © 2011 Japan Pediatric Society. | ||||
| ISSN | 1328-8067 2011 Impact Factor: 0.626 2011 SCImago Journal Rankings: 0.065 | ||||
| DOI | http://dx.doi.org/10.1111/j.1442-200X.2010.03284.x | ||||
| ISI Accession Number ID | WOS:000294026800012
Funding Information: This research was partially supported by the Melamine Incident Funded Project of the Food and Health Bureau, Government of the Hong Kong Special Administrative Region (Project MI-FU-08). | ||||
| References | References in Scopus | ||||
| Grants | Case-control study of Sichuan and Hong Kong children with melamine associated renal stones - renal ultasounds and urinary IL-8 and MCP-1 |
| dc.contributor.author | Wang, Z | ||||
|---|---|---|---|---|---|
| dc.contributor.author | Luo, H | ||||
| dc.contributor.author | Tu, W | ||||
| dc.contributor.author | Yang, H | ||||
| dc.contributor.author | Wong, WHS | ||||
| dc.contributor.author | Wong, WT | ||||
| dc.contributor.author | Yung, KF | ||||
| dc.contributor.author | Zhou, N | ||||
| dc.contributor.author | Zhang, J | ||||
| dc.contributor.author | Li, X | ||||
| dc.contributor.author | Wang, Z | ||||
| dc.contributor.author | Guo, W | ||||
| dc.contributor.author | Mu, D | ||||
| dc.contributor.author | Li, F | ||||
| dc.contributor.author | Mao, M | ||||
| dc.contributor.author | Lau, YL | ||||
| dc.date.accessioned | 2011-07-27T01:38:24Z | ||||
| dc.date.available | 2011-07-27T01:38:24Z | ||||
| dc.date.issued | 2011 | ||||
| dc.description.abstract | Background: An outbreak of urinary stones related to consumption of melamine-tainted milk products (MTMP) occurred in China in 2008. The aim of the present study was to evaluate such children to identify their clinical features and risk factors. Methods: Renal ultrasound was performed for 7328 children who presented to a Sichuan teaching hospital between 13 September and 15 October 2008 due to concern of such stones. Clinical data, family information, feeding history and urinary stones were analyzed. Results: Of the 7328 children, 189 (2.58%) had ultrasound findings of urinary stones, and 51 were admitted. Age (mean ± SD) was 27.4 ± 25.5 months, and 101 were male and 88, female. The odds ratio (OR) for urinary stones for infants and young children (1-3 years) as compared to older children (>3 years), was 2.42 (95% confidence interval [CI], 1.64-3.56; P < 0.0001) and 1.95 (95%CI, 1.31-2.89; P < 0.0011), respectively. Independent risk factors associated with urinary stones included consumption of MTMP with melamine at >5500 mg/kg (OR, 13.3; 95%CI, 6.8-26.1, P < 0.0001) as compared to that with melamine at <200 mg/kg, and younger father (P = 0.0006). On logistic regression, the only risk factor associated with inpatient care was lower family income per person (OR, 4.4; 95%CI, 1.2-15.9, P = 0.02). Repeat ultrasound for 51 children at mean follow up of 15.3 ± 8.9 days found that 33 passed out all stones, which was associated with a larger number of smaller stones (P = 0.003). Urinary stones contained melamine and uric acid, but no cyanuric acid. Conclusions: MTMP-associated urinary stones were more frequent in young children and more severe in children from poorer families. © 2011 Japan Pediatric Society. | ||||
| dc.description.grant | Case-control study of Sichuan and Hong Kong children with melamine associated renal stones - renal ultasounds and urinary IL-8 and MCP-1 | ||||
| dc.description.grantcode | 100083 | ||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||
| dc.identifier.citation | Pediatrics International, 2011, v. 53 n. 4, p. 489-496 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1442-200X.2010.03284.x | ||||
| dc.identifier.citeulike | 9714420 | ||||
| dc.identifier.doi | http://dx.doi.org/10.1111/j.1442-200X.2010.03284.x | ||||
| dc.identifier.epage | 496 | ||||
| dc.identifier.hkuros | 187712 | ||||
| dc.identifier.hkuros | 203918 | ||||
| dc.identifier.isi | WOS:000294026800012
Funding Information: This research was partially supported by the Melamine Incident Funded Project of the Food and Health Bureau, Government of the Hong Kong Special Administrative Region (Project MI-FU-08). | ||||
| dc.identifier.issn | 1328-8067 2011 Impact Factor: 0.626 2011 SCImago Journal Rankings: 0.065 | ||||
| dc.identifier.issue | 4 | ||||
| dc.identifier.pmid | 21040195 | ||||
| dc.identifier.scopus | eid_2-s2.0-80051998321 | ||||
| dc.identifier.spage | 489 | ||||
| dc.identifier.uri | http://hdl.handle.net/10722/135642 | ||||
| dc.identifier.volume | 53 | ||||
| dc.language | eng | ||||
| dc.publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PED | ||||
| dc.publisher.place | Australia | ||||
| dc.relation.ispartof | Pediatrics International | ||||
| dc.relation.references | References in Scopus | ||||
| dc.rights | The definitive version is available at www3.interscience.wiley.com | ||||
| dc.subject | cyanuric acid | ||||
| dc.subject | melamine | ||||
| dc.subject | milk | ||||
| dc.subject | uric acid | ||||
| dc.subject | urinary stones | ||||
| dc.title | Melamine-tainted milk product-associated urinary stones in children | ||||
| dc.type | Article |
Author Affiliations
- European Commission Joint Research Centre
- West China Hospital
- Xian Children's Hospital
- The University of Hong Kong
- West China Second University Hospital