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Article: Melamine-tainted milk product-associated urinary stones in children
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TitleMelamine-tainted milk product-associated urinary stones in children
 
AuthorsWang, Z4
Luo, H4
Tu, W1 2
Yang, H4
Wong, WHS2
Wong, WT2
Yung, KF2
Zhou, N3
Zhang, J3
Li, X3
Wang, Z4
Guo, W4
Mu, D4
Li, F4
Mao, M1 2 4
Lau, YL2
 
Keywordscyanuric acid
melamine
milk
uric acid
urinary stones
 
Issue Date2011
 
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PED
 
CitationPediatrics International, 2011, v. 53 n. 4, p. 489-496 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1442-200X.2010.03284.x
 
AbstractBackground: An outbreak of urinary stones related to consumption of melamine-tainted milk products (MTMP) occurred in China in 2008. The aim of the present study was to evaluate such children to identify their clinical features and risk factors. Methods: Renal ultrasound was performed for 7328 children who presented to a Sichuan teaching hospital between 13 September and 15 October 2008 due to concern of such stones. Clinical data, family information, feeding history and urinary stones were analyzed. Results: Of the 7328 children, 189 (2.58%) had ultrasound findings of urinary stones, and 51 were admitted. Age (mean ± SD) was 27.4 ± 25.5 months, and 101 were male and 88, female. The odds ratio (OR) for urinary stones for infants and young children (1-3 years) as compared to older children (>3 years), was 2.42 (95% confidence interval [CI], 1.64-3.56; P < 0.0001) and 1.95 (95%CI, 1.31-2.89; P < 0.0011), respectively. Independent risk factors associated with urinary stones included consumption of MTMP with melamine at >5500 mg/kg (OR, 13.3; 95%CI, 6.8-26.1, P < 0.0001) as compared to that with melamine at <200 mg/kg, and younger father (P = 0.0006). On logistic regression, the only risk factor associated with inpatient care was lower family income per person (OR, 4.4; 95%CI, 1.2-15.9, P = 0.02). Repeat ultrasound for 51 children at mean follow up of 15.3 ± 8.9 days found that 33 passed out all stones, which was associated with a larger number of smaller stones (P = 0.003). Urinary stones contained melamine and uric acid, but no cyanuric acid. Conclusions: MTMP-associated urinary stones were more frequent in young children and more severe in children from poorer families. © 2011 Japan Pediatric Society.
 
ISSN1328-8067
2012 Impact Factor: 0.875
2012 SCImago Journal Rankings: 0.366
 
DOIhttp://dx.doi.org/10.1111/j.1442-200X.2010.03284.x
 
ISI Accession Number IDWOS:000294026800012
Funding AgencyGrant Number
Melamine Incident Funded ProjectMI-FU-08
Funding Information:

This research was partially supported by the Melamine Incident Funded Project of the Food and Health Bureau, Government of the Hong Kong Special Administrative Region (Project MI-FU-08).

 
ReferencesReferences in Scopus
 
GrantsCase-control study of Sichuan and Hong Kong children with melamine associated renal stones - renal ultasounds and urinary IL-8 and MCP-1
 
DC FieldValue
dc.contributor.authorWang, Z
 
dc.contributor.authorLuo, H
 
dc.contributor.authorTu, W
 
dc.contributor.authorYang, H
 
dc.contributor.authorWong, WHS
 
dc.contributor.authorWong, WT
 
dc.contributor.authorYung, KF
 
dc.contributor.authorZhou, N
 
dc.contributor.authorZhang, J
 
dc.contributor.authorLi, X
 
dc.contributor.authorWang, Z
 
dc.contributor.authorGuo, W
 
dc.contributor.authorMu, D
 
dc.contributor.authorLi, F
 
dc.contributor.authorMao, M
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2011-07-27T01:38:24Z
 
dc.date.available2011-07-27T01:38:24Z
 
dc.date.issued2011
 
dc.description.abstractBackground: An outbreak of urinary stones related to consumption of melamine-tainted milk products (MTMP) occurred in China in 2008. The aim of the present study was to evaluate such children to identify their clinical features and risk factors. Methods: Renal ultrasound was performed for 7328 children who presented to a Sichuan teaching hospital between 13 September and 15 October 2008 due to concern of such stones. Clinical data, family information, feeding history and urinary stones were analyzed. Results: Of the 7328 children, 189 (2.58%) had ultrasound findings of urinary stones, and 51 were admitted. Age (mean ± SD) was 27.4 ± 25.5 months, and 101 were male and 88, female. The odds ratio (OR) for urinary stones for infants and young children (1-3 years) as compared to older children (>3 years), was 2.42 (95% confidence interval [CI], 1.64-3.56; P < 0.0001) and 1.95 (95%CI, 1.31-2.89; P < 0.0011), respectively. Independent risk factors associated with urinary stones included consumption of MTMP with melamine at >5500 mg/kg (OR, 13.3; 95%CI, 6.8-26.1, P < 0.0001) as compared to that with melamine at <200 mg/kg, and younger father (P = 0.0006). On logistic regression, the only risk factor associated with inpatient care was lower family income per person (OR, 4.4; 95%CI, 1.2-15.9, P = 0.02). Repeat ultrasound for 51 children at mean follow up of 15.3 ± 8.9 days found that 33 passed out all stones, which was associated with a larger number of smaller stones (P = 0.003). Urinary stones contained melamine and uric acid, but no cyanuric acid. Conclusions: MTMP-associated urinary stones were more frequent in young children and more severe in children from poorer families. © 2011 Japan Pediatric Society.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationPediatrics International, 2011, v. 53 n. 4, p. 489-496 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1442-200X.2010.03284.x
 
dc.identifier.citeulike9714420
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1442-200X.2010.03284.x
 
dc.identifier.epage496
 
dc.identifier.hkuros187712
 
dc.identifier.hkuros203918
 
dc.identifier.isiWOS:000294026800012
Funding AgencyGrant Number
Melamine Incident Funded ProjectMI-FU-08
Funding Information:

This research was partially supported by the Melamine Incident Funded Project of the Food and Health Bureau, Government of the Hong Kong Special Administrative Region (Project MI-FU-08).

 
dc.identifier.issn1328-8067
2012 Impact Factor: 0.875
2012 SCImago Journal Rankings: 0.366
 
dc.identifier.issue4
 
dc.identifier.pmid21040195
 
dc.identifier.scopuseid_2-s2.0-80051998321
 
dc.identifier.spage489
 
dc.identifier.urihttp://hdl.handle.net/10722/135642
 
dc.identifier.volume53
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PED
 
dc.publisher.placeAustralia
 
dc.relation.ispartofPediatrics International
 
dc.relation.projectCase-control study of Sichuan and Hong Kong children with melamine associated renal stones - renal ultasounds and urinary IL-8 and MCP-1
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www3.interscience.wiley.com
 
dc.subjectcyanuric acid
 
dc.subjectmelamine
 
dc.subjectmilk
 
dc.subjecturic acid
 
dc.subjecturinary stones
 
dc.titleMelamine-tainted milk product-associated urinary stones in children
 
dc.typeArticle
 
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<contributor.author>Tu, W</contributor.author>
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<contributor.author>Wong, WHS</contributor.author>
<contributor.author>Wong, WT</contributor.author>
<contributor.author>Yung, KF</contributor.author>
<contributor.author>Zhou, N</contributor.author>
<contributor.author>Zhang, J</contributor.author>
<contributor.author>Li, X</contributor.author>
<contributor.author>Wang, Z</contributor.author>
<contributor.author>Guo, W</contributor.author>
<contributor.author>Mu, D</contributor.author>
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<description.abstract>Background: An outbreak of urinary stones related to consumption of melamine-tainted milk products (MTMP) occurred in China in 2008. The aim of the present study was to evaluate such children to identify their clinical features and risk factors. Methods: Renal ultrasound was performed for 7328 children who presented to a Sichuan teaching hospital between 13 September and 15 October 2008 due to concern of such stones. Clinical data, family information, feeding history and urinary stones were analyzed. Results: Of the 7328 children, 189 (2.58%) had ultrasound findings of urinary stones, and 51 were admitted. Age (mean &#177; SD) was 27.4 &#177; 25.5 months, and 101 were male and 88, female. The odds ratio (OR) for urinary stones for infants and young children (1-3 years) as compared to older children (&gt;3 years), was 2.42 (95% confidence interval [CI], 1.64-3.56; P &lt; 0.0001) and 1.95 (95%CI, 1.31-2.89; P &lt; 0.0011), respectively. Independent risk factors associated with urinary stones included consumption of MTMP with melamine at &gt;5500 mg/kg (OR, 13.3; 95%CI, 6.8-26.1, P &lt; 0.0001) as compared to that with melamine at &lt;200 mg/kg, and younger father (P = 0.0006). On logistic regression, the only risk factor associated with inpatient care was lower family income per person (OR, 4.4; 95%CI, 1.2-15.9, P = 0.02). Repeat ultrasound for 51 children at mean follow up of 15.3 &#177; 8.9 days found that 33 passed out all stones, which was associated with a larger number of smaller stones (P = 0.003). Urinary stones contained melamine and uric acid, but no cyanuric acid. Conclusions: MTMP-associated urinary stones were more frequent in young children and more severe in children from poorer families. &#169; 2011 Japan Pediatric Society.</description.abstract>
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Author Affiliations
  1. West China Hospital
  2. The University of Hong Kong
  3. Xian Children's Hospital
  4. Sichuan University