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Article: Melamine-tainted milk product-associated urinary stones in children

TitleMelamine-tainted milk product-associated urinary stones in children
Authors
Keywordscyanuric acid
melamine
milk
uric acid
urinary stones
Issue Date2011
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PED
Citation
Pediatrics International, 2011, v. 53 n. 4, p. 489-496 How to Cite?
Abstract
Background: An outbreak of urinary stones related to consumption of melamine-tainted milk products (MTMP) occurred in China in 2008. The aim of the present study was to evaluate such children to identify their clinical features and risk factors. Methods: Renal ultrasound was performed for 7328 children who presented to a Sichuan teaching hospital between 13 September and 15 October 2008 due to concern of such stones. Clinical data, family information, feeding history and urinary stones were analyzed. Results: Of the 7328 children, 189 (2.58%) had ultrasound findings of urinary stones, and 51 were admitted. Age (mean ± SD) was 27.4 ± 25.5 months, and 101 were male and 88, female. The odds ratio (OR) for urinary stones for infants and young children (1-3 years) as compared to older children (>3 years), was 2.42 (95% confidence interval [CI], 1.64-3.56; P < 0.0001) and 1.95 (95%CI, 1.31-2.89; P < 0.0011), respectively. Independent risk factors associated with urinary stones included consumption of MTMP with melamine at >5500 mg/kg (OR, 13.3; 95%CI, 6.8-26.1, P < 0.0001) as compared to that with melamine at <200 mg/kg, and younger father (P = 0.0006). On logistic regression, the only risk factor associated with inpatient care was lower family income per person (OR, 4.4; 95%CI, 1.2-15.9, P = 0.02). Repeat ultrasound for 51 children at mean follow up of 15.3 ± 8.9 days found that 33 passed out all stones, which was associated with a larger number of smaller stones (P = 0.003). Urinary stones contained melamine and uric acid, but no cyanuric acid. Conclusions: MTMP-associated urinary stones were more frequent in young children and more severe in children from poorer families. © 2011 Japan Pediatric Society.
Persistent Identifierhttp://hdl.handle.net/10722/135642
ISSN
2013 Impact Factor: 0.731
ISI Accession Number ID
Funding AgencyGrant Number
Melamine Incident Funded ProjectMI-FU-08
Funding Information:

This research was partially supported by the Melamine Incident Funded Project of the Food and Health Bureau, Government of the Hong Kong Special Administrative Region (Project MI-FU-08).

References
Grants

 

Author Affiliations
  1. West China Hospital
  2. The University of Hong Kong
  3. Xian Children's Hospital
  4. Sichuan University
DC FieldValueLanguage
dc.contributor.authorWang, Zen_HK
dc.contributor.authorLuo, Hen_HK
dc.contributor.authorTu, Wen_HK
dc.contributor.authorYang, Hen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorWong, WTen_HK
dc.contributor.authorYung, KFen_HK
dc.contributor.authorZhou, Nen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorWang, Zen_HK
dc.contributor.authorGuo, Wen_HK
dc.contributor.authorMu, Den_HK
dc.contributor.authorLi, Fen_HK
dc.contributor.authorMao, Men_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2011-07-27T01:38:24Z-
dc.date.available2011-07-27T01:38:24Z-
dc.date.issued2011en_HK
dc.identifier.citationPediatrics International, 2011, v. 53 n. 4, p. 489-496en_HK
dc.identifier.issn1328-8067en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135642-
dc.description.abstractBackground: An outbreak of urinary stones related to consumption of melamine-tainted milk products (MTMP) occurred in China in 2008. The aim of the present study was to evaluate such children to identify their clinical features and risk factors. Methods: Renal ultrasound was performed for 7328 children who presented to a Sichuan teaching hospital between 13 September and 15 October 2008 due to concern of such stones. Clinical data, family information, feeding history and urinary stones were analyzed. Results: Of the 7328 children, 189 (2.58%) had ultrasound findings of urinary stones, and 51 were admitted. Age (mean ± SD) was 27.4 ± 25.5 months, and 101 were male and 88, female. The odds ratio (OR) for urinary stones for infants and young children (1-3 years) as compared to older children (>3 years), was 2.42 (95% confidence interval [CI], 1.64-3.56; P < 0.0001) and 1.95 (95%CI, 1.31-2.89; P < 0.0011), respectively. Independent risk factors associated with urinary stones included consumption of MTMP with melamine at >5500 mg/kg (OR, 13.3; 95%CI, 6.8-26.1, P < 0.0001) as compared to that with melamine at <200 mg/kg, and younger father (P = 0.0006). On logistic regression, the only risk factor associated with inpatient care was lower family income per person (OR, 4.4; 95%CI, 1.2-15.9, P = 0.02). Repeat ultrasound for 51 children at mean follow up of 15.3 ± 8.9 days found that 33 passed out all stones, which was associated with a larger number of smaller stones (P = 0.003). Urinary stones contained melamine and uric acid, but no cyanuric acid. Conclusions: MTMP-associated urinary stones were more frequent in young children and more severe in children from poorer families. © 2011 Japan Pediatric Society.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PEDen_HK
dc.relation.ispartofPediatrics Internationalen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectcyanuric aciden_HK
dc.subjectmelamineen_HK
dc.subjectmilken_HK
dc.subjecturic aciden_HK
dc.subjecturinary stonesen_HK
dc.titleMelamine-tainted milk product-associated urinary stones in childrenen_HK
dc.typeArticleen_HK
dc.identifier.emailTu, W: wwtu@hku.hken_HK
dc.identifier.emailWong, WT: wtwong@hku.hken_HK
dc.identifier.emailYung, KF: kfyung@hkucc.hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.authorityTu, W=rp00416en_HK
dc.identifier.authorityWong, WT=rp00811en_HK
dc.identifier.authorityYung, KF=rp00837en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1442-200X.2010.03284.xen_HK
dc.identifier.pmid21040195en_HK
dc.identifier.scopuseid_2-s2.0-80051998321en_HK
dc.identifier.hkuros187712en_US
dc.identifier.hkuros203918-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80051998321&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue4en_HK
dc.identifier.spage489en_HK
dc.identifier.epage496en_HK
dc.identifier.isiWOS:000294026800012-
dc.publisher.placeAustraliaen_HK
dc.relation.projectCase-control study of Sichuan and Hong Kong children with melamine associated renal stones - renal ultasounds and urinary IL-8 and MCP-1-
dc.identifier.scopusauthoridWang, Z=7410051130en_HK
dc.identifier.scopusauthoridLuo, H=55267057600en_HK
dc.identifier.scopusauthoridTu, W=7006479236en_HK
dc.identifier.scopusauthoridYang, H=35493514000en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridWong, WT=7403973084en_HK
dc.identifier.scopusauthoridYung, KF=7006849172en_HK
dc.identifier.scopusauthoridZhou, N=35202890800en_HK
dc.identifier.scopusauthoridZhang, J=50062207700en_HK
dc.identifier.scopusauthoridLi, X=50061532800en_HK
dc.identifier.scopusauthoridWang, Z=50062104100en_HK
dc.identifier.scopusauthoridGuo, W=55455891400en_HK
dc.identifier.scopusauthoridMu, D=7005487575en_HK
dc.identifier.scopusauthoridLi, F=50061515600en_HK
dc.identifier.scopusauthoridMao, M=14033071500en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.citeulike9714420-

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