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Article: The Iowa Gambling Task in fMRI images
Title | The Iowa Gambling Task in fMRI images | ||||||
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Authors | |||||||
Keywords | Decision making fMRI IGT Somatic marker hypothesis | ||||||
Issue Date | 2010 | ||||||
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751 | ||||||
Citation | Human Brain Mapping, 2010, v. 31 n. 3, p. 410-423 How to Cite? | ||||||
Abstract | The Iowa Gambling Task (IGT) is a sensitive test for the detection of decision-making impairments in several neurological and psychiatric populations. Very few studies have employed the IGT in functional magnetic resonance imaging (fMRI) investigations, in part, because the task is cognitively complex. Here we report a method for exploring brain activity using fMRI during performance of the IGT. Decision-making during the IGT was associated with activity in several brain regions in a group of healthy individuals. The activated regions were consistent with the neural circuitry hypothesized to underlie somatic marker activation and decision-making. Specifically, a neural circuitry involving the dorsolateral prefrontal cortex (for working memory), the insula and posterior cingulate cortex (for representations of emotional states), the mesial orbitofrontal and ventromedial prefrontal cortex (for coupling the two previous processes), the ventral striatum and anterior cingulate/SMA (supplementary motor area) for implementing behavioral decisions was engaged. These results have implications for using the IGT to study abnormal mechanisms of decision making in a variety of clinical populations. © 2009 Wiley-Liss, Inc. | ||||||
Persistent Identifier | http://hdl.handle.net/10722/135571 | ||||||
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.626 | ||||||
PubMed Central ID | |||||||
ISI Accession Number ID |
Funding Information: Contract grant sponsor: National Institute on Drug Abuse (NIDA); Contract grant numbers: DA11779, DA12487, DA16708; Contract grant sponsor: National Science Foundation (NSF), Contract grant number: IIS 04-42586. | ||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, X | en_HK |
dc.contributor.author | Lu, ZL | en_HK |
dc.contributor.author | D'Argembeau, A | en_HK |
dc.contributor.author | Ng, M | en_HK |
dc.contributor.author | Bechara, A | en_HK |
dc.date.accessioned | 2011-07-27T01:37:20Z | - |
dc.date.available | 2011-07-27T01:37:20Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Human Brain Mapping, 2010, v. 31 n. 3, p. 410-423 | en_HK |
dc.identifier.issn | 1065-9471 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/135571 | - |
dc.description.abstract | The Iowa Gambling Task (IGT) is a sensitive test for the detection of decision-making impairments in several neurological and psychiatric populations. Very few studies have employed the IGT in functional magnetic resonance imaging (fMRI) investigations, in part, because the task is cognitively complex. Here we report a method for exploring brain activity using fMRI during performance of the IGT. Decision-making during the IGT was associated with activity in several brain regions in a group of healthy individuals. The activated regions were consistent with the neural circuitry hypothesized to underlie somatic marker activation and decision-making. Specifically, a neural circuitry involving the dorsolateral prefrontal cortex (for working memory), the insula and posterior cingulate cortex (for representations of emotional states), the mesial orbitofrontal and ventromedial prefrontal cortex (for coupling the two previous processes), the ventral striatum and anterior cingulate/SMA (supplementary motor area) for implementing behavioral decisions was engaged. These results have implications for using the IGT to study abnormal mechanisms of decision making in a variety of clinical populations. © 2009 Wiley-Liss, Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751 | en_HK |
dc.relation.ispartof | Human Brain Mapping | en_HK |
dc.rights | Human Brain Mapping. Copyright © John Wiley & Sons, Inc. | - |
dc.subject | Decision making | en_HK |
dc.subject | fMRI | en_HK |
dc.subject | IGT | en_HK |
dc.subject | Somatic marker hypothesis | en_HK |
dc.subject.mesh | Brain - physiology | - |
dc.subject.mesh | Brain Mapping - methods | - |
dc.subject.mesh | Decision Making - physiology | - |
dc.subject.mesh | Gambling | - |
dc.subject.mesh | Magnetic Resonance Imaging - methods | - |
dc.title | The Iowa Gambling Task in fMRI images | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Ng, M: marieng@hku.hk | en_HK |
dc.identifier.authority | Ng, M=rp01451 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1002/hbm.20875 | en_HK |
dc.identifier.pmid | 19777556 | en_HK |
dc.identifier.pmcid | PMC2826566 | - |
dc.identifier.scopus | eid_2-s2.0-77149145482 | en_HK |
dc.identifier.hkuros | 186485 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77149145482&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 31 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 410 | en_HK |
dc.identifier.epage | 423 | en_HK |
dc.identifier.isi | WOS:000275380600007 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Li, X=7501706525 | en_HK |
dc.identifier.scopusauthorid | Lu, ZL=7404769411 | en_HK |
dc.identifier.scopusauthorid | D'Argembeau, A=6603105688 | en_HK |
dc.identifier.scopusauthorid | Ng, M=36155754200 | en_HK |
dc.identifier.scopusauthorid | Bechara, A=7003582694 | en_HK |
dc.identifier.citeulike | 7546391 | - |
dc.identifier.issnl | 1065-9471 | - |