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Article: Proteomics of hepatocellular carcinoma in chinese patients

TitleProteomics of hepatocellular carcinoma in chinese patients
Authors
Issue Date2011
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/publication.aspx?pub_id=43
Citation
Omics A Journal Of Integrative Biology, 2011, v. 15 n. 5, p. 261-266 How to Cite?
AbstractHepatocellular carcinoma (HCC) is a malignant tumor of liver that causes approximately half a million deaths each year, of which over half of the cases are diagnosed in China. Because of its asymptomatic nature, HCC is usually diagnosed at late and advanced stages, for which there are no effective therapies. Thus, biomarkers for early detection and molecular targets for treating HCC are urgently needed. With the advent of high-throughput omics technologies, we have begun to mine the genomics and proteomics information of HCC, and most importantly, these data can be integrated with clinical annotations of the patients. Such new horizons of integrated profiling informatics have allowed us to search for and better identify clinically useful biomarkers and therapeutic targets for cancers including HCC. Capitalizing the large clinical samples cohort (over 100 pairs of tumor and matched adjacent nontumor tissues of HCC), we herein discuss the use of proteomics approach to identify biomarkers that are potentially useful for (1) discrimination of tumorous from nonmalignant tissues, (2) detection of small-sized and early stage of HCC, and (3) prediction of early disease relapse after hepatectomy. © 2011 Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/135558
ISSN
2015 Impact Factor: 2.896
2015 SCImago Journal Rankings: 1.068
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLuk, JMen_HK
dc.contributor.authorLiu, AMen_HK
dc.date.accessioned2011-07-27T01:37:07Z-
dc.date.available2011-07-27T01:37:07Z-
dc.date.issued2011en_HK
dc.identifier.citationOmics A Journal Of Integrative Biology, 2011, v. 15 n. 5, p. 261-266en_HK
dc.identifier.issn1536-2310en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135558-
dc.description.abstractHepatocellular carcinoma (HCC) is a malignant tumor of liver that causes approximately half a million deaths each year, of which over half of the cases are diagnosed in China. Because of its asymptomatic nature, HCC is usually diagnosed at late and advanced stages, for which there are no effective therapies. Thus, biomarkers for early detection and molecular targets for treating HCC are urgently needed. With the advent of high-throughput omics technologies, we have begun to mine the genomics and proteomics information of HCC, and most importantly, these data can be integrated with clinical annotations of the patients. Such new horizons of integrated profiling informatics have allowed us to search for and better identify clinically useful biomarkers and therapeutic targets for cancers including HCC. Capitalizing the large clinical samples cohort (over 100 pairs of tumor and matched adjacent nontumor tissues of HCC), we herein discuss the use of proteomics approach to identify biomarkers that are potentially useful for (1) discrimination of tumorous from nonmalignant tissues, (2) detection of small-sized and early stage of HCC, and (3) prediction of early disease relapse after hepatectomy. © 2011 Mary Ann Liebert, Inc.en_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/publication.aspx?pub_id=43en_HK
dc.relation.ispartofOMICS A Journal of Integrative Biologyen_HK
dc.rightsThis is a copy of an article published in the OMICS: A Journal of Integrative Biology © 2011 Mary Ann Liebert, Inc.; OMICS: A Journal of Integrative Biology is available online at: http://www.liebertonline.com.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAsian Continental Ancestry Group-
dc.subject.meshCarcinoma, Hepatocellular - diagnosis - metabolism-
dc.subject.meshLamin Type B - metabolism-
dc.subject.meshLiver Neoplasms - diagnosis - metabolism-
dc.subject.meshProteomics-
dc.titleProteomics of hepatocellular carcinoma in chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1089/omi.2010.0099en_HK
dc.identifier.pmid21348761-
dc.identifier.scopuseid_2-s2.0-79956126873en_HK
dc.identifier.hkuros188157en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956126873&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue5en_HK
dc.identifier.spage261en_HK
dc.identifier.epage266en_HK
dc.identifier.isiWOS:000290470800002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.scopusauthoridLiu, AM=36134439500en_HK
dc.identifier.citeulike10430021-

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