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Article: Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin

TitleInduction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin
Authors
Keywordshuman hepatocellular carcinoma
mortalin
mutant p53-dependent apoptosis
RNAi
therapy
Issue Date2011
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 2011, v. 129 n. 8, p. 1806-1814 How to Cite?
AbstractStress protein mortalin (mtHSP70) is highly expressed in cancer cells. It was shown to contribute to carcinogenesis by sequestrating the wild type p53, a key tumor suppressor protein, in the cytoplasm resulting in an abrogation of its transcriptional activation function. We have found that the level of mortalin expression has significant correlation with human hepatocellular carcinoma (HCC) malignancy and therefore investigated whether it interacts with and influences the activities of mutant p53, frequently associated with HCC development. We have detected mortalin-p53 interactions in liver tumor and five HCC cell lines that harbored mutant p53. The data was in contrast to the normal liver and immortalized normal hepatocytes that lacked mortalin-p53 interaction. Furthermore, we have found that the shRNA-mediated mortalin silencing could induce mutant p53-mediated tumor-specific apoptosis in HCC. Such allotment of apoptotic function to mutant p53 by targeting mortalin-p53 interaction in cancer cells is a promising strategy for HCC therapy. Copyright © 2010 UICC.
Persistent Identifierhttp://hdl.handle.net/10722/135551
ISSN
2014 Impact Factor: 5.085
2014 SCImago Journal Rankings: 2.175
ISI Accession Number ID
Funding AgencyGrant Number
The HKU CRCG
New Energy & Industrial Technology Development Organization (NEDO)
Funding Information:

Grant sponsors: The HKU CRCG seed fund, New Energy & Industrial Technology Development Organization (NEDO) and Grant-in-Aid for Japan Society for the Promotion of Science (JSPS), Japan

References

 

DC FieldValueLanguage
dc.contributor.authorLu, WJen_HK
dc.contributor.authorLee, NPen_HK
dc.contributor.authorKaul, SCen_HK
dc.contributor.authorLan, Fen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorWadhwa, Ren_HK
dc.contributor.authorLuk, JMen_HK
dc.date.accessioned2011-07-27T01:37:01Z-
dc.date.available2011-07-27T01:37:01Z-
dc.date.issued2011en_HK
dc.identifier.citationInternational Journal Of Cancer, 2011, v. 129 n. 8, p. 1806-1814en_HK
dc.identifier.issn0020-7136en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135551-
dc.description.abstractStress protein mortalin (mtHSP70) is highly expressed in cancer cells. It was shown to contribute to carcinogenesis by sequestrating the wild type p53, a key tumor suppressor protein, in the cytoplasm resulting in an abrogation of its transcriptional activation function. We have found that the level of mortalin expression has significant correlation with human hepatocellular carcinoma (HCC) malignancy and therefore investigated whether it interacts with and influences the activities of mutant p53, frequently associated with HCC development. We have detected mortalin-p53 interactions in liver tumor and five HCC cell lines that harbored mutant p53. The data was in contrast to the normal liver and immortalized normal hepatocytes that lacked mortalin-p53 interaction. Furthermore, we have found that the shRNA-mediated mortalin silencing could induce mutant p53-mediated tumor-specific apoptosis in HCC. Such allotment of apoptotic function to mutant p53 by targeting mortalin-p53 interaction in cancer cells is a promising strategy for HCC therapy. Copyright © 2010 UICC.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_HK
dc.relation.ispartofInternational Journal of Canceren_HK
dc.rightsInternational Journal of Cancer. Copyright © John Wiley & Sons, Inc..-
dc.subjecthuman hepatocellular carcinomaen_HK
dc.subjectmortalinen_HK
dc.subjectmutant p53-dependent apoptosisen_HK
dc.subjectRNAien_HK
dc.subjecttherapyen_HK
dc.titleInduction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalinen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-7136&volume=129&issue=8&spage=1806&epage=1814&date=2010&atitle=Induction+of+mutant+p53-dependent+apoptosis+in+human+hepatocellular+carcinoma+by+targeting+stress+protein+mortalin-
dc.identifier.emailLee, NP: nikkilee@hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityLee, NP=rp00263en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ijc.25857en_HK
dc.identifier.pmid21165951en_US
dc.identifier.scopuseid_2-s2.0-80052036411en_HK
dc.identifier.hkuros188089en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052036411&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume129en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1806en_HK
dc.identifier.epage1814en_HK
dc.identifier.isiWOS:000294224300002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLu, WJ=35187521100en_HK
dc.identifier.scopusauthoridLee, NP=7402722690en_HK
dc.identifier.scopusauthoridKaul, SC=7403092602en_HK
dc.identifier.scopusauthoridLan, F=36349345200en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridWadhwa, R=7006876025en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK

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