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Article: Global Regulation on microRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma
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TitleGlobal Regulation on microRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma
 
AuthorsLiu, AM5 2
Zhang, C4 3
Burchard, J1 4
Fan, ST2
Wong, KF5 2
Dai, H4 3
Poon, RT2
Luk, JM5 2
 
Issue Date2011
 
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/publication.aspx?pub_id=43
 
CitationOmics A Journal Of Integrative Biology, 2011, v. 15 n. 3, p. 187-191 [How to Cite?]
DOI: http://dx.doi.org/10.1089/omi.2010.0098
 
AbstractRecent work has revealed the causative links between deregulation of microRNAs (miRNAs) and cancer development. In hepatocellular carcinoma (HCC), aberrant expression of miRNAs has been observed, but the molecular mechanisms that contribute to such changes remains to be elucidated. Here, we reported the analysis of miRNA expression in 94 pairs of tumor and adjacent nontumor tissues from HBV-associated HCC in Chinese patients. We found miRNAs were aberrantly expressed in HCC tissues. To investigate the cause of such deregulation, we detected changes in DNA copy number by measuring locus-specific hybridization intensity, and found changes in expression of several miRNAs are correlated with genomic amplification or deletion. For example, the genomic regions of miR-30d and miR-151 were amplified in ∼50% of HCC tumor tissues, and the expressions of these miRNAs are significantly correlated with DNA copy number. We also employed cDNA microarray data, and provide evidence that key regulators of the miRNA biosynthetic pathway, including DROSHA, DGCR8, AGO1, and AGO2, are frequently overexpressed in HCC. This study provides molecular clues that may contribute to the global changes of miRNA expression in HCC. Copyright © 2011, Mary Ann Liebert, Inc.
 
ISSN1536-2310
2012 Impact Factor: 2.73
2012 SCImago Journal Rankings: 0.867
 
DOIhttp://dx.doi.org/10.1089/omi.2010.0098
 
ISI Accession Number IDWOS:000288072100013
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLiu, AM
 
dc.contributor.authorZhang, C
 
dc.contributor.authorBurchard, J
 
dc.contributor.authorFan, ST
 
dc.contributor.authorWong, KF
 
dc.contributor.authorDai, H
 
dc.contributor.authorPoon, RT
 
dc.contributor.authorLuk, JM
 
dc.date.accessioned2011-07-27T01:36:49Z
 
dc.date.available2011-07-27T01:36:49Z
 
dc.date.issued2011
 
dc.description.abstractRecent work has revealed the causative links between deregulation of microRNAs (miRNAs) and cancer development. In hepatocellular carcinoma (HCC), aberrant expression of miRNAs has been observed, but the molecular mechanisms that contribute to such changes remains to be elucidated. Here, we reported the analysis of miRNA expression in 94 pairs of tumor and adjacent nontumor tissues from HBV-associated HCC in Chinese patients. We found miRNAs were aberrantly expressed in HCC tissues. To investigate the cause of such deregulation, we detected changes in DNA copy number by measuring locus-specific hybridization intensity, and found changes in expression of several miRNAs are correlated with genomic amplification or deletion. For example, the genomic regions of miR-30d and miR-151 were amplified in ∼50% of HCC tumor tissues, and the expressions of these miRNAs are significantly correlated with DNA copy number. We also employed cDNA microarray data, and provide evidence that key regulators of the miRNA biosynthetic pathway, including DROSHA, DGCR8, AGO1, and AGO2, are frequently overexpressed in HCC. This study provides molecular clues that may contribute to the global changes of miRNA expression in HCC. Copyright © 2011, Mary Ann Liebert, Inc.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationOmics A Journal Of Integrative Biology, 2011, v. 15 n. 3, p. 187-191 [How to Cite?]
DOI: http://dx.doi.org/10.1089/omi.2010.0098
 
dc.identifier.doihttp://dx.doi.org/10.1089/omi.2010.0098
 
dc.identifier.epage191
 
dc.identifier.hkuros187663
 
dc.identifier.isiWOS:000288072100013
 
dc.identifier.issn1536-2310
2012 Impact Factor: 2.73
2012 SCImago Journal Rankings: 0.867
 
dc.identifier.issue3
 
dc.identifier.pmid21319996
 
dc.identifier.scopuseid_2-s2.0-79952499237
 
dc.identifier.spage187
 
dc.identifier.urihttp://hdl.handle.net/10722/135543
 
dc.identifier.volume15
 
dc.languageeng
 
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/publication.aspx?pub_id=43
 
dc.publisher.placeUnited States
 
dc.relation.ispartofOMICS A Journal of Integrative Biology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThis is a copy of an article published in the OMICS: A Journal of Integrative Biology © 2011 Mary Ann Liebert, Inc.; OMICS: A Journal of Integrative Biology is available online at: http://www.liebertonline.com.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshCarcinoma, Hepatocellular - genetics - virology
 
dc.subject.meshGene Expression Regulation, Neoplastic - genetics
 
dc.subject.meshHepatitis B virus - physiology
 
dc.subject.meshLiver Neoplasms - genetics - virology
 
dc.subject.meshMicroRNAs - genetics
 
dc.titleGlobal Regulation on microRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma
 
dc.typeArticle
 
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<contributor.author>Wong, KF</contributor.author>
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Author Affiliations
  1. Sirna Therapeutics Inc.
  2. The University of Hong Kong
  3. Merck Research Laboratories
  4. Rosetta Inpharmatics LLC
  5. National University of Singapore