Article: Global Regulation on microRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma

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TitleGlobal Regulation on microRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma
AuthorsLiu, AM3 5
Zhang, C2 4
Burchard, J1 4
Fan, ST3
Wong, KF3 5
Dai, H2 4
Poon, RT3
Luk, JM3 5
Issue Date2011
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/publication.aspx?pub_id=43
CitationOmics A Journal Of Integrative Biology, 2011, v. 15 n. 3, p. 187-191 [How to Cite?]
DOI: http://dx.doi.org/10.1089/omi.2010.0098
AbstractRecent work has revealed the causative links between deregulation of microRNAs (miRNAs) and cancer development. In hepatocellular carcinoma (HCC), aberrant expression of miRNAs has been observed, but the molecular mechanisms that contribute to such changes remains to be elucidated. Here, we reported the analysis of miRNA expression in 94 pairs of tumor and adjacent nontumor tissues from HBV-associated HCC in Chinese patients. We found miRNAs were aberrantly expressed in HCC tissues. To investigate the cause of such deregulation, we detected changes in DNA copy number by measuring locus-specific hybridization intensity, and found changes in expression of several miRNAs are correlated with genomic amplification or deletion. For example, the genomic regions of miR-30d and miR-151 were amplified in ∼50% of HCC tumor tissues, and the expressions of these miRNAs are significantly correlated with DNA copy number. We also employed cDNA microarray data, and provide evidence that key regulators of the miRNA biosynthetic pathway, including DROSHA, DGCR8, AGO1, and AGO2, are frequently overexpressed in HCC. This study provides molecular clues that may contribute to the global changes of miRNA expression in HCC. Copyright © 2011, Mary Ann Liebert, Inc.
ISSN1536-2310
2011 Impact Factor: 2.441
2011 SCImago Journal Rankings: 0.262
DOIhttp://dx.doi.org/10.1089/omi.2010.0098
ISI Accession Number IDWOS:000288072100013
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLiu, AM
dc.contributor.authorZhang, C
dc.contributor.authorBurchard, J
dc.contributor.authorFan, ST
dc.contributor.authorWong, KF
dc.contributor.authorDai, H
dc.contributor.authorPoon, RT
dc.contributor.authorLuk, JM
dc.date.accessioned2011-07-27T01:36:49Z
dc.date.available2011-07-27T01:36:49Z
dc.date.issued2011
dc.description.abstractRecent work has revealed the causative links between deregulation of microRNAs (miRNAs) and cancer development. In hepatocellular carcinoma (HCC), aberrant expression of miRNAs has been observed, but the molecular mechanisms that contribute to such changes remains to be elucidated. Here, we reported the analysis of miRNA expression in 94 pairs of tumor and adjacent nontumor tissues from HBV-associated HCC in Chinese patients. We found miRNAs were aberrantly expressed in HCC tissues. To investigate the cause of such deregulation, we detected changes in DNA copy number by measuring locus-specific hybridization intensity, and found changes in expression of several miRNAs are correlated with genomic amplification or deletion. For example, the genomic regions of miR-30d and miR-151 were amplified in ∼50% of HCC tumor tissues, and the expressions of these miRNAs are significantly correlated with DNA copy number. We also employed cDNA microarray data, and provide evidence that key regulators of the miRNA biosynthetic pathway, including DROSHA, DGCR8, AGO1, and AGO2, are frequently overexpressed in HCC. This study provides molecular clues that may contribute to the global changes of miRNA expression in HCC. Copyright © 2011, Mary Ann Liebert, Inc.
dc.description.naturepublished_or_final_version
dc.identifier.citationOmics A Journal Of Integrative Biology, 2011, v. 15 n. 3, p. 187-191 [How to Cite?]
DOI: http://dx.doi.org/10.1089/omi.2010.0098
dc.identifier.doihttp://dx.doi.org/10.1089/omi.2010.0098
dc.identifier.epage191
dc.identifier.hkuros187663
dc.identifier.isiWOS:000288072100013
dc.identifier.issn1536-2310
2011 Impact Factor: 2.441
2011 SCImago Journal Rankings: 0.262
dc.identifier.issue3
dc.identifier.pmid21319996
dc.identifier.scopuseid_2-s2.0-79952499237
dc.identifier.spage187
dc.identifier.urihttp://hdl.handle.net/10722/135543
dc.identifier.volume15
dc.languageeng
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/publication.aspx?pub_id=43
dc.publisher.placeUnited States
dc.relation.ispartofOMICS A Journal of Integrative Biology
dc.relation.referencesReferences in Scopus
dc.rightsThis is a copy of an article published in the OMICS: A Journal of Integrative Biology © 2011 Mary Ann Liebert, Inc.; OMICS: A Journal of Integrative Biology is available online at: http://www.liebertonline.com.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshCarcinoma, Hepatocellular - genetics - virology
dc.subject.meshGene Expression Regulation, Neoplastic - genetics
dc.subject.meshHepatitis B virus - physiology
dc.subject.meshLiver Neoplasms - genetics - virology
dc.subject.meshMicroRNAs - genetics
dc.titleGlobal Regulation on microRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma
dc.typeArticle
Author Affiliations
  1. Sirna Therapeutics Inc.
  2. Merck Research Laboratories
  3. The University of Hong Kong
  4. Merck & Co.
  5. National University of Singapore