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Article: Global Regulation on microRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma

TitleGlobal Regulation on microRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma
Authors
Issue Date2011
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/publication.aspx?pub_id=43
Citation
Omics A Journal Of Integrative Biology, 2011, v. 15 n. 3, p. 187-191 How to Cite?
Abstract
Recent work has revealed the causative links between deregulation of microRNAs (miRNAs) and cancer development. In hepatocellular carcinoma (HCC), aberrant expression of miRNAs has been observed, but the molecular mechanisms that contribute to such changes remains to be elucidated. Here, we reported the analysis of miRNA expression in 94 pairs of tumor and adjacent nontumor tissues from HBV-associated HCC in Chinese patients. We found miRNAs were aberrantly expressed in HCC tissues. To investigate the cause of such deregulation, we detected changes in DNA copy number by measuring locus-specific hybridization intensity, and found changes in expression of several miRNAs are correlated with genomic amplification or deletion. For example, the genomic regions of miR-30d and miR-151 were amplified in ∼50% of HCC tumor tissues, and the expressions of these miRNAs are significantly correlated with DNA copy number. We also employed cDNA microarray data, and provide evidence that key regulators of the miRNA biosynthetic pathway, including DROSHA, DGCR8, AGO1, and AGO2, are frequently overexpressed in HCC. This study provides molecular clues that may contribute to the global changes of miRNA expression in HCC. Copyright © 2011, Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/135543
ISSN
2013 Impact Factor: 2.730
2013 SCImago Journal Rankings: 1.085
ISI Accession Number ID
References

 

Author Affiliations
  1. Sirna Therapeutics Inc.
  2. The University of Hong Kong
  3. Merck Research Laboratories
  4. Rosetta Inpharmatics LLC
  5. National University of Singapore
DC FieldValueLanguage
dc.contributor.authorLiu, AMen_HK
dc.contributor.authorZhang, Cen_HK
dc.contributor.authorBurchard, Jen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorWong, KFen_HK
dc.contributor.authorDai, Hen_HK
dc.contributor.authorPoon, RTen_HK
dc.contributor.authorLuk, JMen_HK
dc.date.accessioned2011-07-27T01:36:49Z-
dc.date.available2011-07-27T01:36:49Z-
dc.date.issued2011en_HK
dc.identifier.citationOmics A Journal Of Integrative Biology, 2011, v. 15 n. 3, p. 187-191en_HK
dc.identifier.issn1536-2310en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135543-
dc.description.abstractRecent work has revealed the causative links between deregulation of microRNAs (miRNAs) and cancer development. In hepatocellular carcinoma (HCC), aberrant expression of miRNAs has been observed, but the molecular mechanisms that contribute to such changes remains to be elucidated. Here, we reported the analysis of miRNA expression in 94 pairs of tumor and adjacent nontumor tissues from HBV-associated HCC in Chinese patients. We found miRNAs were aberrantly expressed in HCC tissues. To investigate the cause of such deregulation, we detected changes in DNA copy number by measuring locus-specific hybridization intensity, and found changes in expression of several miRNAs are correlated with genomic amplification or deletion. For example, the genomic regions of miR-30d and miR-151 were amplified in ∼50% of HCC tumor tissues, and the expressions of these miRNAs are significantly correlated with DNA copy number. We also employed cDNA microarray data, and provide evidence that key regulators of the miRNA biosynthetic pathway, including DROSHA, DGCR8, AGO1, and AGO2, are frequently overexpressed in HCC. This study provides molecular clues that may contribute to the global changes of miRNA expression in HCC. Copyright © 2011, Mary Ann Liebert, Inc.en_HK
dc.languageengen_US
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/publication.aspx?pub_id=43en_HK
dc.relation.ispartofOMICS A Journal of Integrative Biologyen_HK
dc.rightsThis is a copy of an article published in the OMICS: A Journal of Integrative Biology © 2011 Mary Ann Liebert, Inc.; OMICS: A Journal of Integrative Biology is available online at: http://www.liebertonline.com.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCarcinoma, Hepatocellular - genetics - virology-
dc.subject.meshGene Expression Regulation, Neoplastic - genetics-
dc.subject.meshHepatitis B virus - physiology-
dc.subject.meshLiver Neoplasms - genetics - virology-
dc.subject.meshMicroRNAs - genetics-
dc.titleGlobal Regulation on microRNA in Hepatitis B Virus-Associated Hepatocellular Carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailPoon, RT: poontp@hkucc.hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityPoon, RT=rp00446en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1089/omi.2010.0098en_HK
dc.identifier.pmid21319996en_HK
dc.identifier.scopuseid_2-s2.0-79952499237en_HK
dc.identifier.hkuros187663en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952499237&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue3en_HK
dc.identifier.spage187en_HK
dc.identifier.epage191en_HK
dc.identifier.isiWOS:000288072100013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, AM=36134439500en_HK
dc.identifier.scopusauthoridZhang, C=9747304800en_HK
dc.identifier.scopusauthoridBurchard, J=35586927300en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridWong, KF=35081410800en_HK
dc.identifier.scopusauthoridDai, H=7402206916en_HK
dc.identifier.scopusauthoridPoon, RT=7103097223en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK

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