Article: Laparoscopic liver resection for hepatocellular carcinoma

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleLaparoscopic liver resection for hepatocellular carcinoma
AuthorsChung, CD1
Lau, LL1
Ko, KL1
Wong, AC1
Wong, S1
Chan, AC1 2
Poon, RT1
Lo, CM1
Fan, ST1
Keywordshepatocellular carcinoma
laparoscopic liver resection
Issue Date2010
PublisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
CitationAsian Journal Of Surgery, 2010, v. 33 n. 4, p. 168-172 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S1015-9584(11)60002-X
AbstractOBJECTIVE: To provide an updated review on the clinical experience in laparoscopic liver resection, specifically for hepatocellular carcinoma. METHODS: A comprehensive literature search in MEDLINE was conducted for all English papers up to May 2010 on laparoscopic liver resection for hepatocellular carcinoma. Patient characteristics, perioperative results, and oncologic outcomes were compared and analysed. RESULTS: We analysed 11 clinical studies involving 466 hepatocellular carcinoma patients treated with laparoscopic hepatectomy. Thirty-seven (9%) patients underwent major resection. Cirrhosis occurred in 62%. The mean operative time was 189.5 min, and the mean blood loss was 315.6 mL. Blood transfusion was required in 14.6% of patients. There were two operative deaths. Postoperative complications included bile leakage (1%), bleeding (2.9%), liver failure (5.1%), and ascites (6%). The 1-year, 3-year, and 5-year diseasefree survival rates ranged from 60% to 90%, 50% to 64%, and 31% to 50%, respectively, and the corresponding overall survival rates ranged from 85% to 100%, 67% to 100%, and 50% to 97% respectively. CONCLUSION: Laparoscopic liver resection for hepatocellular carcinoma appears to be safe and to achieve acceptable oncologic outcomes even in cirrhotic livers, but whether it is comparable to conventional open surgery needs to be evaluated in a randomized, controlled trial setting. © 2010 Asian Surgical Association.
ISSN1015-9584
2011 Impact Factor: 0.575
2011 SCImago Journal Rankings: 0.070
DOIhttp://dx.doi.org/10.1016/S1015-9584(11)60002-X
ISI Accession Number IDWOS:000288476100002
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChung, CD
dc.contributor.authorLau, LL
dc.contributor.authorKo, KL
dc.contributor.authorWong, AC
dc.contributor.authorWong, S
dc.contributor.authorChan, AC
dc.contributor.authorPoon, RT
dc.contributor.authorLo, CM
dc.contributor.authorFan, ST
dc.date.accessioned2011-07-27T01:36:47Z
dc.date.available2011-07-27T01:36:47Z
dc.date.issued2010
dc.description.abstractOBJECTIVE: To provide an updated review on the clinical experience in laparoscopic liver resection, specifically for hepatocellular carcinoma. METHODS: A comprehensive literature search in MEDLINE was conducted for all English papers up to May 2010 on laparoscopic liver resection for hepatocellular carcinoma. Patient characteristics, perioperative results, and oncologic outcomes were compared and analysed. RESULTS: We analysed 11 clinical studies involving 466 hepatocellular carcinoma patients treated with laparoscopic hepatectomy. Thirty-seven (9%) patients underwent major resection. Cirrhosis occurred in 62%. The mean operative time was 189.5 min, and the mean blood loss was 315.6 mL. Blood transfusion was required in 14.6% of patients. There were two operative deaths. Postoperative complications included bile leakage (1%), bleeding (2.9%), liver failure (5.1%), and ascites (6%). The 1-year, 3-year, and 5-year diseasefree survival rates ranged from 60% to 90%, 50% to 64%, and 31% to 50%, respectively, and the corresponding overall survival rates ranged from 85% to 100%, 67% to 100%, and 50% to 97% respectively. CONCLUSION: Laparoscopic liver resection for hepatocellular carcinoma appears to be safe and to achieve acceptable oncologic outcomes even in cirrhotic livers, but whether it is comparable to conventional open surgery needs to be evaluated in a randomized, controlled trial setting. © 2010 Asian Surgical Association.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAsian Journal Of Surgery, 2010, v. 33 n. 4, p. 168-172 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S1015-9584(11)60002-X
dc.identifier.doihttp://dx.doi.org/10.1016/S1015-9584(11)60002-X
dc.identifier.epage172
dc.identifier.hkuros187658
dc.identifier.isiWOS:000288476100002
dc.identifier.issn1015-9584
2011 Impact Factor: 0.575
2011 SCImago Journal Rankings: 0.070
dc.identifier.issue4
dc.identifier.openurl
dc.identifier.pmid21377102
dc.identifier.scopuseid_2-s2.0-79952382942
dc.identifier.spage168
dc.identifier.urihttp://hdl.handle.net/10722/135542
dc.identifier.volume33
dc.languageeng
dc.publisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
dc.publisher.placeHong Kong
dc.relation.ispartofAsian Journal of Surgery
dc.relation.referencesReferences in Scopus
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI#
dc.subject.meshCarcinoma, Hepatocellular - mortality - surgery
dc.subject.meshDisease-Free Survival
dc.subject.meshHepatectomy - statistics and numerical data
dc.subject.meshLaparoscopy - statistics and numerical data
dc.subject.meshLiver Neoplasms - mortality - surgery
dc.subjecthepatocellular carcinoma
dc.subjectlaparoscopic liver resection
dc.titleLaparoscopic liver resection for hepatocellular carcinoma
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong