Article: High-intensity focused ultrasound for hepatocellular carcinoma: A single-center experience

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TitleHigh-intensity focused ultrasound for hepatocellular carcinoma: A single-center experience
AuthorsNg, KKC1
Poon, RTP1
Chan, SC1
Chok, KSH1
Cheung, TT1
Tung, H1
Chu, F1
Tso, WK1
Yu, WC1
Lo, CM1
Fan, ST1
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com
CitationAnnals Of Surgery, 2011, v. 253 n. 5, p. 981-987 [How to Cite?]
DOI: http://dx.doi.org/10.1097/SLA.0b013e3182128a8b
AbstractObjective: This study aims to evaluate the outcome of patients with hepatocellular carcinoma (HCC) treated by high-intensity focused ultrasound (HIFU) in a single tertiary referral center. Background: HIFU is the latest developed local ablation technique for unresectable HCC. The initial experience on its efficacy is promising, but the survival benefit of patients undergoing HIFU for HCC is poorly defined. Methods: From October 2006 to December 2008, 49 patients received HIFU for unresectable HCC. Each patient underwent a single session of HIFU with a curative intent. Treatment efficacy and survival outcome were evaluated. Clinicopathologic factors affecting the primary technique effectiveness and overall survival rates were investigated by univariate analysis. Results: The median size of the treated tumors was 2.2 cm, ranging from 0.9 to 8 cm. The majority of patients had single tumors (n = 41, 83.6%). Thirty-one patients (63.2%) had artificial right pleural effusion during HIFU treatment to reduce damage to the lung and diaphragm. The hospital mortality rate was 2% (n = 1) and the complication rate was 8.1% (n = 4). The primary technique effectiveness rate was 79.5% (39 of 49 patients). It increased from 66.6% in the initial series to 89.2% in the last 28 patients. Tumor size (3.0 cm) was the significant risk factor affecting the complete ablation rate. The 1- and 3-year overall survival rates were 87.7% and 62.4%, respectively. Child-Pugh liver function grading was the significant prognostic factor influencing the overall survival rate. Conclusions: HIFU is an effective treatment modality for unresectable HCC with a high technique effectiveness rate and favorable survival outcome. © 2011 Lippincott Williams & Wilkins.
ISSN0003-4932
2011 Impact Factor: 7.492
2011 SCImago Journal Rankings: 0.617
DOIhttp://dx.doi.org/10.1097/SLA.0b013e3182128a8b
ISI Accession Number IDWOS:000289510600021
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorNg, KKC
dc.contributor.authorPoon, RTP
dc.contributor.authorChan, SC
dc.contributor.authorChok, KSH
dc.contributor.authorCheung, TT
dc.contributor.authorTung, H
dc.contributor.authorChu, F
dc.contributor.authorTso, WK
dc.contributor.authorYu, WC
dc.contributor.authorLo, CM
dc.contributor.authorFan, ST
dc.date.accessioned2011-07-27T01:36:46Z
dc.date.available2011-07-27T01:36:46Z
dc.date.issued2011
dc.description.abstractObjective: This study aims to evaluate the outcome of patients with hepatocellular carcinoma (HCC) treated by high-intensity focused ultrasound (HIFU) in a single tertiary referral center. Background: HIFU is the latest developed local ablation technique for unresectable HCC. The initial experience on its efficacy is promising, but the survival benefit of patients undergoing HIFU for HCC is poorly defined. Methods: From October 2006 to December 2008, 49 patients received HIFU for unresectable HCC. Each patient underwent a single session of HIFU with a curative intent. Treatment efficacy and survival outcome were evaluated. Clinicopathologic factors affecting the primary technique effectiveness and overall survival rates were investigated by univariate analysis. Results: The median size of the treated tumors was 2.2 cm, ranging from 0.9 to 8 cm. The majority of patients had single tumors (n = 41, 83.6%). Thirty-one patients (63.2%) had artificial right pleural effusion during HIFU treatment to reduce damage to the lung and diaphragm. The hospital mortality rate was 2% (n = 1) and the complication rate was 8.1% (n = 4). The primary technique effectiveness rate was 79.5% (39 of 49 patients). It increased from 66.6% in the initial series to 89.2% in the last 28 patients. Tumor size (3.0 cm) was the significant risk factor affecting the complete ablation rate. The 1- and 3-year overall survival rates were 87.7% and 62.4%, respectively. Child-Pugh liver function grading was the significant prognostic factor influencing the overall survival rate. Conclusions: HIFU is an effective treatment modality for unresectable HCC with a high technique effectiveness rate and favorable survival outcome. © 2011 Lippincott Williams & Wilkins.
dc.description.naturepostprint
dc.identifier.citationAnnals Of Surgery, 2011, v. 253 n. 5, p. 981-987 [How to Cite?]
DOI: http://dx.doi.org/10.1097/SLA.0b013e3182128a8b
dc.identifier.doihttp://dx.doi.org/10.1097/SLA.0b013e3182128a8b
dc.identifier.epage987
dc.identifier.hkuros187648
dc.identifier.isiWOS:000289510600021
dc.identifier.issn0003-4932
2011 Impact Factor: 7.492
2011 SCImago Journal Rankings: 0.617
dc.identifier.issue5
dc.identifier.openurl
dc.identifier.pmid21394012
dc.identifier.scopuseid_2-s2.0-79954631974
dc.identifier.spage981
dc.identifier.urihttp://hdl.handle.net/10722/135541
dc.identifier.volume253
dc.languageeng
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com
dc.publisher.placeUnited States
dc.relation.ispartofAnnals of Surgery
dc.relation.referencesReferences in Scopus
dc.rightsThis is a non-final version of an article published in final form in Annals of Surgery, 2011, v. 253 n. 5, p. 981-987
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshCarcinoma, Hepatocellular - mortality - pathology - therapy
dc.subject.meshCohort Studies
dc.subject.meshHigh-Intensity Focused Ultrasound Ablation - methods
dc.subject.meshLiver Neoplasms - mortality - pathology - therapy
dc.subject.meshPalliative Care
dc.titleHigh-intensity focused ultrasound for hepatocellular carcinoma: A single-center experience
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong