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Article: Changing trend in surgical indication and management for Graves' disease

TitleChanging trend in surgical indication and management for Graves' disease
Authors
KeywordsGraves' disease
Endocrine ophthalmopathy
Hypoparathyroidism
Thyroidectomy
Relapse
Issue Date2012
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurg
Citation
The American Journal of Surgery, 2012, v. 203 n. 2, p. 162-167 How to Cite?
AbstractBACKGROUND: Although thyroidectomy for Graves' disease (GD) is well established, surgical indications remain less well defined. This study aimed to evaluate the changes in surgical indication, type of resection, and surgical outcomes at a single institution. METHODS: A total of 346 patients who underwent thyroidectomy for GD were divided into 2 time periods: period 1 (1995-2001) and period 2 (2002-2008). Their surgical indication, type of resection, and surgical outcomes were compared. RESULTS: Patients in the earlier period were significantly younger, suffered more previous relapses, and were on a longer duration of antithyroid drugs before surgery. Graves' ophthalmopathy and refusal for radioactive iodine were the indications that changed significantly between the 2 periods. Total/near-total thyroidectomy was performed more commonly and resulted in a higher temporary hypoparathyroidism rate in the latter period (P < .001). CONCLUSIONS: Over the study period, significant changes in surgical indication, type of resection, and surgical outcomes were noted. Graves' ophthalmopathy became one of the most common surgical indications. Total thyroidectomy became the preferred surgery but that resulted in a higher temporary hypoparathyroidism rate.
Persistent Identifierhttp://hdl.handle.net/10722/135532
ISSN
2015 Impact Factor: 2.403
2015 SCImago Journal Rankings: 1.286
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYip, Jen_US
dc.contributor.authorLang, BHHen_US
dc.contributor.authorLo, CYen_US
dc.date.accessioned2011-07-27T01:36:36Z-
dc.date.available2011-07-27T01:36:36Z-
dc.date.issued2012en_US
dc.identifier.citationThe American Journal of Surgery, 2012, v. 203 n. 2, p. 162-167en_US
dc.identifier.issn0002-9610-
dc.identifier.urihttp://hdl.handle.net/10722/135532-
dc.description.abstractBACKGROUND: Although thyroidectomy for Graves' disease (GD) is well established, surgical indications remain less well defined. This study aimed to evaluate the changes in surgical indication, type of resection, and surgical outcomes at a single institution. METHODS: A total of 346 patients who underwent thyroidectomy for GD were divided into 2 time periods: period 1 (1995-2001) and period 2 (2002-2008). Their surgical indication, type of resection, and surgical outcomes were compared. RESULTS: Patients in the earlier period were significantly younger, suffered more previous relapses, and were on a longer duration of antithyroid drugs before surgery. Graves' ophthalmopathy and refusal for radioactive iodine were the indications that changed significantly between the 2 periods. Total/near-total thyroidectomy was performed more commonly and resulted in a higher temporary hypoparathyroidism rate in the latter period (P < .001). CONCLUSIONS: Over the study period, significant changes in surgical indication, type of resection, and surgical outcomes were noted. Graves' ophthalmopathy became one of the most common surgical indications. Total thyroidectomy became the preferred surgery but that resulted in a higher temporary hypoparathyroidism rate.-
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurg-
dc.relation.ispartofThe American Journal of Surgeryen_US
dc.subjectGraves' disease-
dc.subjectEndocrine ophthalmopathy-
dc.subjectHypoparathyroidism-
dc.subjectThyroidectomy-
dc.subjectRelapse-
dc.titleChanging trend in surgical indication and management for Graves' diseaseen_US
dc.typeArticleen_US
dc.identifier.emailLang, BHH: blang@hkucc.hku.hken_US
dc.identifier.emailLo, CY: cylo@hkucc.hku.hken_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.amjsurg.2011.01.029en_US
dc.identifier.pmid21683939-
dc.identifier.scopuseid_2-s2.0-84856082396en_US
dc.identifier.hkuros187595en_US
dc.identifier.volume203-
dc.identifier.issue2-
dc.identifier.spage162-
dc.identifier.epage167-
dc.identifier.isiWOS:000300770700008-
dc.publisher.placeUnited States-
dc.identifier.citeulike9489137-

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