Article: Concordance between side-stream end-tidal carbon dioxide and arterial carbon dioxide partial pressure in respiratory service setting

File Download Links for fulltext
(May Require Subscription)
Supplementary

  • Basic View
  • Metadata View
  • XML View
TitleConcordance between side-stream end-tidal carbon dioxide and arterial carbon dioxide partial pressure in respiratory service setting
AuthorsLaw, GTS1
Wong, CY3
Kwan, CW2
Wong, KY1
Wong, FP1
Tse, HN1
Issue Date2009
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
CitationHong Kong Medical Journal, 2009, v. 15 n. 6, p. 440-446 [How to Cite?]
AbstractOBJECTIVE: To explore the correlation and concordance between end-tidal carbon dioxide and arterial carbon dioxide partial pressure, and confirm the experience of the general consensus among service environments. DESIGN: A prospective cross-sectional analysis. SETTING: Two respiratory service units in Hong Kong. PARTICIPANTS: Two hundred respiratory patients were recruited, in whom 219 sets of observations were recorded. Patients deemed to require arterial blood gas determination also had their end-tidal carbon dioxide partial pressure measured at that time, using two LifeSense LS1-9R Capnometers. MAIN OUTCOME MEASURES: The agreement of end-tidal carbon dioxide partial pressure and arterial carbon dioxide partial pressure was studied by correlation coefficients, mean and standard deviation of their difference, and the Bland-Altman plot. RESULTS: Overall, the correlation was low and insignificant (r=0.1185, P=0.0801). The mean of the difference was 7.2 torr (95% confidence interval, 5.5-8.9) and significant (P<0.001). The limits of agreement by Bland-Altman analysis were -18.1 to 32.5 torr, which were too large to be acceptable. In the sub-group on room air, the mean difference was reduced to 2.26 torr, the correlation between end-tidal carbon dioxide partial pressure and arterial carbon dioxide partial pressure was 0.2194 (P=0.0068), though statistically significant, the extent of correlation was still low. CONCLUSION: End-tidal carbon dioxide partial pressure did not show significant correlation or concordance with arterial carbon dioxide partial pressure, especially when supplemental oxygen was used. End-tidal carbon dioxide partial pressure currently cannot replace arterial blood gas measurement as a tool for monitoring arterial carbon dioxide partial pressure. Possible reasons for the discrepancy with previous studies include small sample size in previous studies, lack of research facilities in service settings, and publication bias against negative studies.
ISSN1024-2708
2011 SCImago Journal Rankings: 0.054
DC Field
Value
dc.contributor.authorLaw, GTS
dc.contributor.authorWong, CY
dc.contributor.authorKwan, CW
dc.contributor.authorWong, KY
dc.contributor.authorWong, FP
dc.contributor.authorTse, HN
dc.date.accessioned2011-07-27T01:36:11Z
dc.date.available2011-07-27T01:36:11Z
dc.date.issued2009
dc.description.abstractOBJECTIVE: To explore the correlation and concordance between end-tidal carbon dioxide and arterial carbon dioxide partial pressure, and confirm the experience of the general consensus among service environments. DESIGN: A prospective cross-sectional analysis. SETTING: Two respiratory service units in Hong Kong. PARTICIPANTS: Two hundred respiratory patients were recruited, in whom 219 sets of observations were recorded. Patients deemed to require arterial blood gas determination also had their end-tidal carbon dioxide partial pressure measured at that time, using two LifeSense LS1-9R Capnometers. MAIN OUTCOME MEASURES: The agreement of end-tidal carbon dioxide partial pressure and arterial carbon dioxide partial pressure was studied by correlation coefficients, mean and standard deviation of their difference, and the Bland-Altman plot. RESULTS: Overall, the correlation was low and insignificant (r=0.1185, P=0.0801). The mean of the difference was 7.2 torr (95% confidence interval, 5.5-8.9) and significant (P<0.001). The limits of agreement by Bland-Altman analysis were -18.1 to 32.5 torr, which were too large to be acceptable. In the sub-group on room air, the mean difference was reduced to 2.26 torr, the correlation between end-tidal carbon dioxide partial pressure and arterial carbon dioxide partial pressure was 0.2194 (P=0.0068), though statistically significant, the extent of correlation was still low. CONCLUSION: End-tidal carbon dioxide partial pressure did not show significant correlation or concordance with arterial carbon dioxide partial pressure, especially when supplemental oxygen was used. End-tidal carbon dioxide partial pressure currently cannot replace arterial blood gas measurement as a tool for monitoring arterial carbon dioxide partial pressure. Possible reasons for the discrepancy with previous studies include small sample size in previous studies, lack of research facilities in service settings, and publication bias against negative studies.
dc.description.naturepublished_or_final_version
dc.identifier.citationHong Kong Medical Journal, 2009, v. 15 n. 6, p. 440-446 [How to Cite?]
dc.identifier.epage446
dc.identifier.hkuros187886
dc.identifier.issn1024-2708
2011 SCImago Journal Rankings: 0.054
dc.identifier.issue6
dc.identifier.openurl
dc.identifier.pmid19966348
dc.identifier.scopuseid_2-s2.0-76749144222
dc.identifier.spage440
dc.identifier.urihttp://hdl.handle.net/10722/135510
dc.identifier.volume15
dc.languageeng
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
dc.relation.ispartofHong Kong Medical Journal
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.
dc.subject.meshBlood Gas Analysis
dc.subject.meshBreath Tests - instrumentation - methods
dc.subject.meshCarbon Dioxide - analysis - blood
dc.subject.meshPartial Pressure
dc.subject.meshRespiratory Insufficiency - blood - physiopathology
dc.titleConcordance between side-stream end-tidal carbon dioxide and arterial carbon dioxide partial pressure in respiratory service setting
dc.typeArticle
Author Affiliations
  1. Kwong Wah Hospital
  2. The University of Hong Kong
  3. Wong Tai Sin Hospital