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Article: European bone mineral density loci are also associated with BMD in East-Asian populations
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TitleEuropean bone mineral density loci are also associated with BMD in East-Asian populations
 
AuthorsStyrkarsdottir, U3
Halldorsson, BV1 3
Gudbjartsson, DF3
Tang, NLS9
Koh, JM6 5
Xiao, SM2
Kwok, TCY9
Kim, GS6 5
Chan, JCN9
Cherny, S2
Lee, SH6 5
Kwok, A9
Ho, S9
Gretarsdottir, S3
Kostic, JP3
Palsson, ST3
Sigurdsson, G8 4
Sham, PC2
Kim, BJ6 5
Kung, AWC2
Kim, SY5 7
Woo, J9
Leung, PC9
Kong, A3
Thorsteinsdottir, U3 4
Stefansson, K3 4
 
Issue Date2010
 
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
CitationPlos One, 2010, v. 5 n. 10 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0013217
 
AbstractMost genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment of the influence of the sequence variants on populations of other ethnicities. To determine whether markers that we have recently shown to associate with Bone Mineral Density (BMD) in Europeans also associate with BMD in East-Asians we analysed 50 markers from 23 genomic loci in samples from Korea (n = 1,397) and two Chinese Hong Kong sample sets (n = 3,869 and n = 785). Through this effort we identified fourteen loci that associated with BMD in East-Asian samples using a false discovery rate (FDR) of 0.05; 1p36 (ZBTB40, P = 4.3×10 -9), 1p31 (GPR177, P = 0.00012), 3p22 (CTNNB1, P = 0.00013), 4q22 (MEPE, P = 0.0026), 5q14 (MEF2C, P = 1.3×10 -5), 6q25 (ESR1, P = 0.0011), 7p14 (STARD3NL, P = 0.00025), 7q21 (FLJ42280, P = 0.00017), 8q24 (TNFRSF11B, P = 3.4×10 -5), 11p15 (SOX6, P = 0.00033), 11q13 (LRP5, P = 0.0033), 13q14 (TNFSF11, P = 7.5×10 -5), 16q24 (FOXL1, P = 0.0010) and 17q21 (SOST, P = 0.015). Our study marks an early effort towards the challenge of cataloguing bone density variants shared by many ethnicities by testing BMD variants that have been established in Europeans, in East-Asians. © 2010 Styrkarsdottir et al.
 
ISSN1932-6203
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
 
DOIhttp://dx.doi.org/10.1371/journal.pone.0013217
 
PubMed Central IDPMC2951352
 
ISI Accession Number IDWOS:000282633700012
Funding AgencyGrant Number
European CommunityFP7/2007-2013
HEALTH-F2-2008-201865-GEFOS
Korea Healthcare Technology
Ministry for Health, Welfare & Family Affairs, Republic of KoreaA010252
Research Grants Council of Hong KongCUHK 4101/02M
Chinese University of Hong Kong
Centre for Nutritional Studies
School of Public Health and Primary Care
Hong Kong Jockey Club Charities Foundation
Hong Kong Research Grant Council
HKU Foundation
University of Hong Kong
deCODE Genetics
Funding Information:

This work was supported by deCODE Genetics and funded in part by the European Community's Seventh Framework Programme (FP7/2007-2013)/grant agreement HEALTH-F2-2008-201865-GEFOS. The Korean study was supported by a grant from the Korea Healthcare Technology R& D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (Project No.: A010252). The Chinese Hong Kong-I study was supported in part by grants from Research Grants Council of Hong Kong, (CUHK 4101/02M), Direct Grant from the Chinese University of Hong Kong, the Centre for Nutritional Studies, School of Public Health and Primary Care, and the Hong Kong Jockey Club Charities Foundation. The Hong Kong-II study was supported by Hong Kong Research Grant Council; The Bone Health fund of HKU Foundation; Matching Grant, CRCG Grant and The Osteoporosis Research Fund of The University of Hong Kong. The study design, data generation (in part), overall analysis of data, decision to publish and preparation of the manuscript was lead by employees of deCODE Genetics, a funder of this study.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorStyrkarsdottir, U
 
dc.contributor.authorHalldorsson, BV
 
dc.contributor.authorGudbjartsson, DF
 
dc.contributor.authorTang, NLS
 
dc.contributor.authorKoh, JM
 
dc.contributor.authorXiao, SM
 
dc.contributor.authorKwok, TCY
 
dc.contributor.authorKim, GS
 
dc.contributor.authorChan, JCN
 
dc.contributor.authorCherny, S
 
dc.contributor.authorLee, SH
 
dc.contributor.authorKwok, A
 
dc.contributor.authorHo, S
 
dc.contributor.authorGretarsdottir, S
 
dc.contributor.authorKostic, JP
 
dc.contributor.authorPalsson, ST
 
dc.contributor.authorSigurdsson, G
 
dc.contributor.authorSham, PC
 
dc.contributor.authorKim, BJ
 
dc.contributor.authorKung, AWC
 
dc.contributor.authorKim, SY
 
dc.contributor.authorWoo, J
 
dc.contributor.authorLeung, PC
 
dc.contributor.authorKong, A
 
dc.contributor.authorThorsteinsdottir, U
 
dc.contributor.authorStefansson, K
 
dc.date.accessioned2011-07-27T01:35:09Z
 
dc.date.available2011-07-27T01:35:09Z
 
dc.date.issued2010
 
dc.description.abstractMost genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment of the influence of the sequence variants on populations of other ethnicities. To determine whether markers that we have recently shown to associate with Bone Mineral Density (BMD) in Europeans also associate with BMD in East-Asians we analysed 50 markers from 23 genomic loci in samples from Korea (n = 1,397) and two Chinese Hong Kong sample sets (n = 3,869 and n = 785). Through this effort we identified fourteen loci that associated with BMD in East-Asian samples using a false discovery rate (FDR) of 0.05; 1p36 (ZBTB40, P = 4.3×10 -9), 1p31 (GPR177, P = 0.00012), 3p22 (CTNNB1, P = 0.00013), 4q22 (MEPE, P = 0.0026), 5q14 (MEF2C, P = 1.3×10 -5), 6q25 (ESR1, P = 0.0011), 7p14 (STARD3NL, P = 0.00025), 7q21 (FLJ42280, P = 0.00017), 8q24 (TNFRSF11B, P = 3.4×10 -5), 11p15 (SOX6, P = 0.00033), 11q13 (LRP5, P = 0.0033), 13q14 (TNFSF11, P = 7.5×10 -5), 16q24 (FOXL1, P = 0.0010) and 17q21 (SOST, P = 0.015). Our study marks an early effort towards the challenge of cataloguing bone density variants shared by many ethnicities by testing BMD variants that have been established in Europeans, in East-Asians. © 2010 Styrkarsdottir et al.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationPlos One, 2010, v. 5 n. 10 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0013217
 
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0013217
 
dc.identifier.epagee13217
 
dc.identifier.hkuros188279
 
dc.identifier.hkuros187294
 
dc.identifier.isiWOS:000282633700012
Funding AgencyGrant Number
European CommunityFP7/2007-2013
HEALTH-F2-2008-201865-GEFOS
Korea Healthcare Technology
Ministry for Health, Welfare & Family Affairs, Republic of KoreaA010252
Research Grants Council of Hong KongCUHK 4101/02M
Chinese University of Hong Kong
Centre for Nutritional Studies
School of Public Health and Primary Care
Hong Kong Jockey Club Charities Foundation
Hong Kong Research Grant Council
HKU Foundation
University of Hong Kong
deCODE Genetics
Funding Information:

This work was supported by deCODE Genetics and funded in part by the European Community's Seventh Framework Programme (FP7/2007-2013)/grant agreement HEALTH-F2-2008-201865-GEFOS. The Korean study was supported by a grant from the Korea Healthcare Technology R& D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (Project No.: A010252). The Chinese Hong Kong-I study was supported in part by grants from Research Grants Council of Hong Kong, (CUHK 4101/02M), Direct Grant from the Chinese University of Hong Kong, the Centre for Nutritional Studies, School of Public Health and Primary Care, and the Hong Kong Jockey Club Charities Foundation. The Hong Kong-II study was supported by Hong Kong Research Grant Council; The Bone Health fund of HKU Foundation; Matching Grant, CRCG Grant and The Osteoporosis Research Fund of The University of Hong Kong. The study design, data generation (in part), overall analysis of data, decision to publish and preparation of the manuscript was lead by employees of deCODE Genetics, a funder of this study.

 
dc.identifier.issn1932-6203
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
 
dc.identifier.issue10
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC2951352
 
dc.identifier.pmid20949110
 
dc.identifier.scopuseid_2-s2.0-78049233765
 
dc.identifier.spagee13217
 
dc.identifier.urihttp://hdl.handle.net/10722/135438
 
dc.identifier.volume5
 
dc.languageeng
 
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
dc.publisher.placeUnited States
 
dc.relation.ispartofPLoS ONE
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAsian Continental Ancestry Group - genetics
 
dc.subject.meshBone Density - genetics
 
dc.subject.meshEuropean Continental Ancestry Group - genetics
 
dc.subject.meshGenome-Wide Association Study
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.titleEuropean bone mineral density loci are also associated with BMD in East-Asian populations
 
dc.typeArticle
 
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Author Affiliations
  1. Reykjavik University
  2. The University of Hong Kong
  3. deCODE Genetics
  4. University of Iceland
  5. Kyungpook National University Hospital
  6. University of Ulsan, College of Medicine
  7. Kyungpook National University, School of Medicine
  8. Landspitali University Hospital
  9. Chinese University of Hong Kong