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Article: Facial emotion processing in schizophrenia: A meta-analysis of functional neuroimaging data

TitleFacial emotion processing in schizophrenia: A meta-analysis of functional neuroimaging data
Authors
Keywordsamygdala
emotion perception
meta-analysis
schizophrenia
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
Schizophrenia Bulletin, 2010, v. 36 n. 5, p. 1029-1039 How to Cite?
AbstractBackground: People with schizophrenia have difficulty with emotion perception. Functional imaging studies indicate regional brain activation abnormalities in patients with schizophrenia when processing facial emotion. However, findings have not been entirely consistent across different studies. Methods: Activation likelihood estimation (ALE) meta-analyses were conducted to examine brain activation during facial emotion processing in patients with schizophrenia, controls, and patients compared with controls. Secondary meta-analyses were performed to assess the contribution of task design and illness chronicity to the results reported. Results: When processing facial expressions of emotions, both patients with schizophrenia and healthy controls activated the bilateral amygdala and right fusiform gyri. However, the extent of activation in these regions was generally much more limited in the schizophrenia samples. When directly compared with controls, the extent of activation in bilateral amygdala, parahippocampal gyrus and fusiform gyrus, right superior frontal gyrus, and lentiform nucleus was significantly less in patients. Patients with schizophrenia, but not controls, activated the left insula. A relative failure to recruit the amygdala in patients occurred regardless of whether the task design was explicit or implicit, while differences in fusiform activation were evident in explicit, not implicit, tasks. Restricting the analysis to patients with chronic illness did not substantially change the results. Conclusions: A marked underrecruitment of the amygdala, accompanied by a substantial limitation in activation throughout a ventral temporal-basal ganglia-prefrontal cortex "social brain" system may be central to the difficulties patients experience when processing facial emotion. © The Author 2009.
Persistent Identifierhttp://hdl.handle.net/10722/135415
ISSN
2015 Impact Factor: 7.757
2015 SCImago Journal Rankings: 4.051
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
100-Scholar ProgrammeO7CX031003
Institute of Psychology, Chinese Academy of SciencesKSCX2-YW-R-131
National Science Foundation of China30770723
National Basic Research Programme (973 Programme)2007CB512302
2007CB512305
Funding Information:

Research Initiation Fund of the 100-Scholar Programme (O7CX031003); Institute of Psychology, Chinese Academy of Sciences (Research Fund KSCX2-YW-R-131); National Science Foundation of China (30770723); National Basic Research Programme (973 Programme No. 2007CB512302, 2007CB512305).

References

 

DC FieldValueLanguage
dc.contributor.authorLi, Hen_HK
dc.contributor.authorChan, RCKen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorGong, QYen_HK
dc.date.accessioned2011-07-27T01:34:53Z-
dc.date.available2011-07-27T01:34:53Z-
dc.date.issued2010en_HK
dc.identifier.citationSchizophrenia Bulletin, 2010, v. 36 n. 5, p. 1029-1039en_HK
dc.identifier.issn0586-7614en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135415-
dc.description.abstractBackground: People with schizophrenia have difficulty with emotion perception. Functional imaging studies indicate regional brain activation abnormalities in patients with schizophrenia when processing facial emotion. However, findings have not been entirely consistent across different studies. Methods: Activation likelihood estimation (ALE) meta-analyses were conducted to examine brain activation during facial emotion processing in patients with schizophrenia, controls, and patients compared with controls. Secondary meta-analyses were performed to assess the contribution of task design and illness chronicity to the results reported. Results: When processing facial expressions of emotions, both patients with schizophrenia and healthy controls activated the bilateral amygdala and right fusiform gyri. However, the extent of activation in these regions was generally much more limited in the schizophrenia samples. When directly compared with controls, the extent of activation in bilateral amygdala, parahippocampal gyrus and fusiform gyrus, right superior frontal gyrus, and lentiform nucleus was significantly less in patients. Patients with schizophrenia, but not controls, activated the left insula. A relative failure to recruit the amygdala in patients occurred regardless of whether the task design was explicit or implicit, while differences in fusiform activation were evident in explicit, not implicit, tasks. Restricting the analysis to patients with chronic illness did not substantially change the results. Conclusions: A marked underrecruitment of the amygdala, accompanied by a substantial limitation in activation throughout a ventral temporal-basal ganglia-prefrontal cortex "social brain" system may be central to the difficulties patients experience when processing facial emotion. © The Author 2009.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/en_HK
dc.relation.ispartofSchizophrenia Bulletinen_HK
dc.subjectamygdalaen_HK
dc.subjectemotion perceptionen_HK
dc.subjectmeta-analysisen_HK
dc.subjectschizophreniaen_HK
dc.subject.meshBrain - physiopathology-
dc.subject.meshEmotions - physiology-
dc.subject.meshFacial Expression-
dc.subject.meshPattern Recognition, Visual - physiology-
dc.subject.meshSchizophrenia - diagnosis - physiopathology-
dc.titleFacial emotion processing in schizophrenia: A meta-analysis of functional neuroimaging dataen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0586-7614&volume=36&issue=5&spage=1029&epage=1039&date=2010&atitle=Facial+emotion+processing+in+schizophrenia:+a+meta-analysis+of+functional+neuroimaging+data-
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/schbul/sbn190en_HK
dc.identifier.pmid19336391-
dc.identifier.pmcidPMC2930350-
dc.identifier.scopuseid_2-s2.0-77955972572en_HK
dc.identifier.hkuros187345en_US
dc.identifier.hkuros167690-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955972572&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1029en_HK
dc.identifier.epage1039en_HK
dc.identifier.isiWOS:000281188100019-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, H=27171755000en_HK
dc.identifier.scopusauthoridChan, RCK=35236280300en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridGong, QY=7201440871en_HK
dc.identifier.citeulike10131228-

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