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Article: Gray matter in first-episode schizophrenia before and after antipsychotic drug treatment. Anatomical likelihood estimation meta-analyses with sample size weighting
Title | Gray matter in first-episode schizophrenia before and after antipsychotic drug treatment. Anatomical likelihood estimation meta-analyses with sample size weighting | ||||
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Authors | |||||
Keywords | ALEn brain structure meta-analysis neuroleptic naive subtraction analysis voxel-based morphometry | ||||
Issue Date | 2011 | ||||
Publisher | Oxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/ | ||||
Citation | Schizophrenia Bulletin, 2011, v. 37 n. 1, p. 199-211 How to Cite? | ||||
Abstract | Background: Cerebral morphological abnormalities in schizophrenia may be modulated by treatment, chronicity, and duration of illness. Comparing brain imaging studies of individuals with first-episode schizophrenia and neuroleptic naive (NN-FES) with that of their neuroleptic-treated counterparts (NT-FES) can help to dissect out the effect of these potential confounders. Methods: We used the anatomical likelihood estimation method to compare voxel-based morphometric studies of NN-FES (n = 162 patients) and NT-FES (n = 336 patients) studies. The analysis included a sample size weighting step based on the Liptak-Stouffer method to reflect the greater power of larger studies. Results: Patient samples were matched for age, gender, and duration of illness. An extensive network of gray matter deficits in frontal, temporal, insular, striatal, posterior cingulate, and cerebellar regions was detected in the NN-FES samples as compared with healthy controls. Major deficits were detected in the frontal, superior temporal, insular, and parahippocampal regions for the NT-FES group compared with the NN-FES group. In addition, the NT-FES group showed minor deficits in the caudate, cingulate, and inferior temporal regions compared with the NN-FES group. There were no regions with gray matter volumetric excess in the NT-FES group. Conclusion: Frontal, striato-limbic, and temporal morphological abnormalities are present in the early stage of schizophrenia and are unrelated to the effects of neuroleptic treatment, chronicity, and duration of illness. There may be dynamic effects of treatment on striato-limbic and temporal, but not frontal, regional gray matter volumes of the brain. © 2010 The Author. | ||||
Persistent Identifier | http://hdl.handle.net/10722/135414 | ||||
ISSN | 2023 Impact Factor: 5.3 2023 SCImago Journal Rankings: 2.249 | ||||
PubMed Central ID | |||||
ISI Accession Number ID |
Funding Information: The University of Hong Kong Research Postgraduate studentship to M. L.; The University of Hong Kong Funding to S.C. | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leung, M | en_HK |
dc.contributor.author | Cheung, C | en_HK |
dc.contributor.author | Yu, K | en_HK |
dc.contributor.author | Yip, B | en_HK |
dc.contributor.author | Sham, P | en_HK |
dc.contributor.author | Li, Q | en_HK |
dc.contributor.author | Chua, S | en_HK |
dc.contributor.author | McAlonan, G | en_HK |
dc.date.accessioned | 2011-07-27T01:34:52Z | - |
dc.date.available | 2011-07-27T01:34:52Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Schizophrenia Bulletin, 2011, v. 37 n. 1, p. 199-211 | en_HK |
dc.identifier.issn | 0586-7614 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/135414 | - |
dc.description.abstract | Background: Cerebral morphological abnormalities in schizophrenia may be modulated by treatment, chronicity, and duration of illness. Comparing brain imaging studies of individuals with first-episode schizophrenia and neuroleptic naive (NN-FES) with that of their neuroleptic-treated counterparts (NT-FES) can help to dissect out the effect of these potential confounders. Methods: We used the anatomical likelihood estimation method to compare voxel-based morphometric studies of NN-FES (n = 162 patients) and NT-FES (n = 336 patients) studies. The analysis included a sample size weighting step based on the Liptak-Stouffer method to reflect the greater power of larger studies. Results: Patient samples were matched for age, gender, and duration of illness. An extensive network of gray matter deficits in frontal, temporal, insular, striatal, posterior cingulate, and cerebellar regions was detected in the NN-FES samples as compared with healthy controls. Major deficits were detected in the frontal, superior temporal, insular, and parahippocampal regions for the NT-FES group compared with the NN-FES group. In addition, the NT-FES group showed minor deficits in the caudate, cingulate, and inferior temporal regions compared with the NN-FES group. There were no regions with gray matter volumetric excess in the NT-FES group. Conclusion: Frontal, striato-limbic, and temporal morphological abnormalities are present in the early stage of schizophrenia and are unrelated to the effects of neuroleptic treatment, chronicity, and duration of illness. There may be dynamic effects of treatment on striato-limbic and temporal, but not frontal, regional gray matter volumes of the brain. © 2010 The Author. | en_HK |
dc.language | eng | en_US |
dc.publisher | Oxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/ | en_HK |
dc.relation.ispartof | Schizophrenia Bulletin | en_HK |
dc.subject | ALEn | en_HK |
dc.subject | brain structure | en_HK |
dc.subject | meta-analysis | en_HK |
dc.subject | neuroleptic naive | en_HK |
dc.subject | subtraction analysis | en_HK |
dc.subject | voxel-based morphometry | en_HK |
dc.subject.mesh | Antipsychotic Agents - therapeutic use | - |
dc.subject.mesh | Brain - pathology | - |
dc.subject.mesh | Disease Progression | - |
dc.subject.mesh | Frontal Lobe - pathology | - |
dc.subject.mesh | Schizophrenia - drug therapy - pathology | - |
dc.title | Gray matter in first-episode schizophrenia before and after antipsychotic drug treatment. Anatomical likelihood estimation meta-analyses with sample size weighting | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0586-7614&volume=37&issue=1&spage=199&epage=211&date=2011&atitle=Gray+matter+in+first-episode+schizophrenia+before+and+after+antipsychotic+drug+treatment:+anatomical+likelihood+estimation+meta-analyses+with+sample+size+weighting | - |
dc.identifier.email | Cheung, C: charlton@hkucc.hku.hk | en_HK |
dc.identifier.email | Sham, P: pcsham@hku.hk | en_HK |
dc.identifier.email | Chua, S: sechua@hku.hk | en_HK |
dc.identifier.email | McAlonan, G: mcalonan@hkucc.hku.hk | en_HK |
dc.identifier.authority | Cheung, C=rp01574 | en_HK |
dc.identifier.authority | Sham, P=rp00459 | en_HK |
dc.identifier.authority | Chua, S=rp00438 | en_HK |
dc.identifier.authority | McAlonan, G=rp00475 | en_HK |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1093/schbul/sbp099 | en_HK |
dc.identifier.pmid | 19759093 | - |
dc.identifier.pmcid | PMC3004197 | - |
dc.identifier.scopus | eid_2-s2.0-78651338152 | en_HK |
dc.identifier.hkuros | 187344 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-78651338152&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 37 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 199 | en_HK |
dc.identifier.epage | 211 | en_HK |
dc.identifier.isi | WOS:000285845300024 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Leung, M=36552785900 | en_HK |
dc.identifier.scopusauthorid | Cheung, C=7202061845 | en_HK |
dc.identifier.scopusauthorid | Yu, K=36706689100 | en_HK |
dc.identifier.scopusauthorid | Yip, B=16685586100 | en_HK |
dc.identifier.scopusauthorid | Sham, P=34573429300 | en_HK |
dc.identifier.scopusauthorid | Li, Q=22034705700 | en_HK |
dc.identifier.scopusauthorid | Chua, S=7201550427 | en_HK |
dc.identifier.scopusauthorid | McAlonan, G=6603123011 | en_HK |
dc.identifier.citeulike | 10462761 | - |
dc.identifier.issnl | 0586-7614 | - |