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Article: Abnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophrenia
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TitleAbnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophrenia
 
AuthorsWang, Q3
Deng, W3
Huang, C3
Li, M3
Ma, X3
Wang, Y3
Jiang, L3
Lui, S3
Huang, X3
Chua, SE2
Cheung, C2
McAlonan, GM2
Sham, PC2
Murray, RM1
Collier, DA1
Gong, Q3
Li, T3 1
 
KeywordsDTI
family history
first episode
fractional anisotropy
schizophrenia
voxel-based analysis
 
Issue Date2011
 
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
 
CitationPsychological Medicine, 2011, v. 41 n. 8, p. 1691-1700 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0033291710002412
 
AbstractBackground Abnormalities in the connectivity of white-matter (WM) tracts in schizophrenia are supported by evidence from post-mortem investigations, functional and structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). The aims of this study were to explore the microstructural changes in first-episode schizophrenia in a Han Chinese population and to investigate whether a family history of psychiatric disorder is related to the severity of WM tract integrity abnormalities in these patients.Method T1-weighted MR and DT images were collected in 68 patients with first-episode schizophrenia [22 with a positive family history (PFH) and 46 with a negative family history (NFH)] and 100 healthy controls. Voxel-based analysis was performed and WM integrity was quantified by fractional anisotropy (FA). Cluster-and voxel-level analyses were performed by using two-sample t tests between patients and controls and/or using a full factorial model with one factor and three levels among the three sample groups (patients with PFH or NFH, and controls), as appropriate.Results FA deficits were observed in the patient group, especially in the left temporal lobe and right corpus callosum. This effect was more severe in the non-familial schizophrenia than in the familial schizophrenia subgroup.Conclusions Overall, these findings support the hypothesis that loss of WM integrity may be an important pathophysiological feature of schizophrenia, with particular implications for brain dysmaturation in non-familial and familial schizophrenia. © 2011 Cambridge University Press.
 
ISSN0033-2917
2012 Impact Factor: 5.587
2012 SCImago Journal Rankings: 2.581
 
DOIhttp://dx.doi.org/10.1017/S0033291710002412
 
ISI Accession Number IDWOS:000292704400011
Funding AgencyGrant Number
National Nature Science Foundation of China30 971 056
30 530 300
30 125 014
National Basic Research Programme of China (973 Programme)2007CB512301
2007CB512305
NARSAD
Wellcome Trust
Funding Information:

This work was funded partly by the National Nature Science Foundation of China (grant 30 971 056 to W. Q.; grants 30 530 300 and 30 125 014 to T. L.), the National Basic Research Programme of China (973 Programme 2007CB512301 to T. L.; 2007CB512305 to Q. G.), the NARSAD Independent Investigator Award (T. L.), and the Wellcome Trust (International Collaborative Award to T. L., D. A. C. and X. L.). We also thank two anonymous reviewers for their comprehensive comments, which greatly improved the manuscript.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWang, Q
 
dc.contributor.authorDeng, W
 
dc.contributor.authorHuang, C
 
dc.contributor.authorLi, M
 
dc.contributor.authorMa, X
 
dc.contributor.authorWang, Y
 
dc.contributor.authorJiang, L
 
dc.contributor.authorLui, S
 
dc.contributor.authorHuang, X
 
dc.contributor.authorChua, SE
 
dc.contributor.authorCheung, C
 
dc.contributor.authorMcAlonan, GM
 
dc.contributor.authorSham, PC
 
dc.contributor.authorMurray, RM
 
dc.contributor.authorCollier, DA
 
dc.contributor.authorGong, Q
 
dc.contributor.authorLi, T
 
dc.date.accessioned2011-07-27T01:34:51Z
 
dc.date.available2011-07-27T01:34:51Z
 
dc.date.issued2011
 
dc.description.abstractBackground Abnormalities in the connectivity of white-matter (WM) tracts in schizophrenia are supported by evidence from post-mortem investigations, functional and structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). The aims of this study were to explore the microstructural changes in first-episode schizophrenia in a Han Chinese population and to investigate whether a family history of psychiatric disorder is related to the severity of WM tract integrity abnormalities in these patients.Method T1-weighted MR and DT images were collected in 68 patients with first-episode schizophrenia [22 with a positive family history (PFH) and 46 with a negative family history (NFH)] and 100 healthy controls. Voxel-based analysis was performed and WM integrity was quantified by fractional anisotropy (FA). Cluster-and voxel-level analyses were performed by using two-sample t tests between patients and controls and/or using a full factorial model with one factor and three levels among the three sample groups (patients with PFH or NFH, and controls), as appropriate.Results FA deficits were observed in the patient group, especially in the left temporal lobe and right corpus callosum. This effect was more severe in the non-familial schizophrenia than in the familial schizophrenia subgroup.Conclusions Overall, these findings support the hypothesis that loss of WM integrity may be an important pathophysiological feature of schizophrenia, with particular implications for brain dysmaturation in non-familial and familial schizophrenia. © 2011 Cambridge University Press.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationPsychological Medicine, 2011, v. 41 n. 8, p. 1691-1700 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0033291710002412
 
dc.identifier.doihttp://dx.doi.org/10.1017/S0033291710002412
 
dc.identifier.epage1700
 
dc.identifier.hkuros187271
 
dc.identifier.isiWOS:000292704400011
Funding AgencyGrant Number
National Nature Science Foundation of China30 971 056
30 530 300
30 125 014
National Basic Research Programme of China (973 Programme)2007CB512301
2007CB512305
NARSAD
Wellcome Trust
Funding Information:

This work was funded partly by the National Nature Science Foundation of China (grant 30 971 056 to W. Q.; grants 30 530 300 and 30 125 014 to T. L.), the National Basic Research Programme of China (973 Programme 2007CB512301 to T. L.; 2007CB512305 to Q. G.), the NARSAD Independent Investigator Award (T. L.), and the Wellcome Trust (International Collaborative Award to T. L., D. A. C. and X. L.). We also thank two anonymous reviewers for their comprehensive comments, which greatly improved the manuscript.

 
dc.identifier.issn0033-2917
2012 Impact Factor: 5.587
2012 SCImago Journal Rankings: 2.581
 
dc.identifier.issue8
 
dc.identifier.openurl
 
dc.identifier.pmid21205362
 
dc.identifier.scopuseid_2-s2.0-80054966968
 
dc.identifier.spage1691
 
dc.identifier.urihttp://hdl.handle.net/10722/135413
 
dc.identifier.volume41
 
dc.languageeng
 
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofPsychological Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshBrain - pathology
 
dc.subject.meshChi-Square Distribution
 
dc.subject.meshDiffusion Tensor Imaging
 
dc.subject.meshMagnetic Resonance Imaging
 
dc.subject.meshSchizophrenia - genetics - pathology
 
dc.subjectDTI
 
dc.subjectfamily history
 
dc.subjectfirst episode
 
dc.subjectfractional anisotropy
 
dc.subjectschizophrenia
 
dc.subjectvoxel-based analysis
 
dc.titleAbnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophrenia
 
dc.typeArticle
 
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Author Affiliations
  1. King's College London
  2. The University of Hong Kong
  3. Sichuan University