Article: Abnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophrenia

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TitleAbnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophrenia
AuthorsWang, Q3
Deng, W3
Huang, C3
Li, M3
Ma, X3
Wang, Y3
Jiang, L3
Lui, S3
Huang, X3
Chua, SE2
Cheung, C2
McAlonan, GM2
Sham, PC2
Murray, RM1
Collier, DA1
Gong, Q3
Li, T1 3
KeywordsDTI
family history
first episode
fractional anisotropy
schizophrenia
voxel-based analysis
Issue Date2011
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
CitationPsychological Medicine, 2011, v. 41 n. 8, p. 1691-1700 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0033291710002412
AbstractBackground Abnormalities in the connectivity of white-matter (WM) tracts in schizophrenia are supported by evidence from post-mortem investigations, functional and structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). The aims of this study were to explore the microstructural changes in first-episode schizophrenia in a Han Chinese population and to investigate whether a family history of psychiatric disorder is related to the severity of WM tract integrity abnormalities in these patients.Method T1-weighted MR and DT images were collected in 68 patients with first-episode schizophrenia [22 with a positive family history (PFH) and 46 with a negative family history (NFH)] and 100 healthy controls. Voxel-based analysis was performed and WM integrity was quantified by fractional anisotropy (FA). Cluster-and voxel-level analyses were performed by using two-sample t tests between patients and controls and/or using a full factorial model with one factor and three levels among the three sample groups (patients with PFH or NFH, and controls), as appropriate.Results FA deficits were observed in the patient group, especially in the left temporal lobe and right corpus callosum. This effect was more severe in the non-familial schizophrenia than in the familial schizophrenia subgroup.Conclusions Overall, these findings support the hypothesis that loss of WM integrity may be an important pathophysiological feature of schizophrenia, with particular implications for brain dysmaturation in non-familial and familial schizophrenia. © 2011 Cambridge University Press.
ISSN0033-2917
2011 Impact Factor: 6.159
2011 SCImago Journal Rankings: 0.269
DOIhttp://dx.doi.org/10.1017/S0033291710002412
ISI Accession Number IDWOS:000292704400011
Funding AgencyGrant Number
National Nature Science Foundation of China30 971 056
30 530 300
30 125 014
National Basic Research Programme of China (973 Programme)2007CB512301
2007CB512305
NARSAD
Wellcome Trust
Funding Information:

This work was funded partly by the National Nature Science Foundation of China (grant 30 971 056 to W. Q.; grants 30 530 300 and 30 125 014 to T. L.), the National Basic Research Programme of China (973 Programme 2007CB512301 to T. L.; 2007CB512305 to Q. G.), the NARSAD Independent Investigator Award (T. L.), and the Wellcome Trust (International Collaborative Award to T. L., D. A. C. and X. L.). We also thank two anonymous reviewers for their comprehensive comments, which greatly improved the manuscript.

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWang, Q
dc.contributor.authorDeng, W
dc.contributor.authorHuang, C
dc.contributor.authorLi, M
dc.contributor.authorMa, X
dc.contributor.authorWang, Y
dc.contributor.authorJiang, L
dc.contributor.authorLui, S
dc.contributor.authorHuang, X
dc.contributor.authorChua, SE
dc.contributor.authorCheung, C
dc.contributor.authorMcAlonan, GM
dc.contributor.authorSham, PC
dc.contributor.authorMurray, RM
dc.contributor.authorCollier, DA
dc.contributor.authorGong, Q
dc.contributor.authorLi, T
dc.date.accessioned2011-07-27T01:34:51Z
dc.date.available2011-07-27T01:34:51Z
dc.date.issued2011
dc.description.abstractBackground Abnormalities in the connectivity of white-matter (WM) tracts in schizophrenia are supported by evidence from post-mortem investigations, functional and structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). The aims of this study were to explore the microstructural changes in first-episode schizophrenia in a Han Chinese population and to investigate whether a family history of psychiatric disorder is related to the severity of WM tract integrity abnormalities in these patients.Method T1-weighted MR and DT images were collected in 68 patients with first-episode schizophrenia [22 with a positive family history (PFH) and 46 with a negative family history (NFH)] and 100 healthy controls. Voxel-based analysis was performed and WM integrity was quantified by fractional anisotropy (FA). Cluster-and voxel-level analyses were performed by using two-sample t tests between patients and controls and/or using a full factorial model with one factor and three levels among the three sample groups (patients with PFH or NFH, and controls), as appropriate.Results FA deficits were observed in the patient group, especially in the left temporal lobe and right corpus callosum. This effect was more severe in the non-familial schizophrenia than in the familial schizophrenia subgroup.Conclusions Overall, these findings support the hypothesis that loss of WM integrity may be an important pathophysiological feature of schizophrenia, with particular implications for brain dysmaturation in non-familial and familial schizophrenia. © 2011 Cambridge University Press.
dc.description.naturepublished_or_final_version
dc.identifier.citationPsychological Medicine, 2011, v. 41 n. 8, p. 1691-1700 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0033291710002412
dc.identifier.doihttp://dx.doi.org/10.1017/S0033291710002412
dc.identifier.epage1700
dc.identifier.hkuros187271
dc.identifier.isiWOS:000292704400011
Funding AgencyGrant Number
National Nature Science Foundation of China30 971 056
30 530 300
30 125 014
National Basic Research Programme of China (973 Programme)2007CB512301
2007CB512305
NARSAD
Wellcome Trust
Funding Information:

This work was funded partly by the National Nature Science Foundation of China (grant 30 971 056 to W. Q.; grants 30 530 300 and 30 125 014 to T. L.), the National Basic Research Programme of China (973 Programme 2007CB512301 to T. L.; 2007CB512305 to Q. G.), the NARSAD Independent Investigator Award (T. L.), and the Wellcome Trust (International Collaborative Award to T. L., D. A. C. and X. L.). We also thank two anonymous reviewers for their comprehensive comments, which greatly improved the manuscript.

dc.identifier.issn0033-2917
2011 Impact Factor: 6.159
2011 SCImago Journal Rankings: 0.269
dc.identifier.issue8
dc.identifier.openurl
dc.identifier.pmid21205362
dc.identifier.scopuseid_2-s2.0-80054966968
dc.identifier.spage1691
dc.identifier.urihttp://hdl.handle.net/10722/135413
dc.identifier.volume41
dc.languageeng
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
dc.publisher.placeUnited Kingdom
dc.relation.ispartofPsychological Medicine
dc.relation.referencesReferences in Scopus
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshBrain - pathology
dc.subject.meshChi-Square Distribution
dc.subject.meshDiffusion Tensor Imaging
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshSchizophrenia - genetics - pathology
dc.subjectDTI
dc.subjectfamily history
dc.subjectfirst episode
dc.subjectfractional anisotropy
dc.subjectschizophrenia
dc.subjectvoxel-based analysis
dc.titleAbnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophrenia
dc.typeArticle
Author Affiliations
  1. King's College London
  2. The University of Hong Kong
  3. Sichuan University