Article: The neuropathological contribution of prenatal inflammation to schizophrenia

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Publisher Website: 10.1586/ern.10.169
Scopus: eid_2-s2.0-78650359084
PMID: 21158552

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Title	The neuropathological contribution of prenatal inflammation to schizophrenia
Authors	Meyer, U1 Weiner, I3 McAlonan, GM2 Feldon, J1
Keywords	cerebrospinal fluid cytokines enthorinal cortex hippocampus immune system infection MRI neurodevelopment prevention ventricles
Issue Date	2011
Publisher	Expert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/ern
Citation	Expert Review Of Neurotherapeutics, 2011, v. 11 n. 1, p. 29-32 [How to Cite?] DOI: http://dx.doi.org/10.1586/ern.10.169
Abstract	Maternal infection and/or inflammation during pregnancy has been repeatedly shown to elevate the risk of schizophrenia and related psychotic disorders in offspring. However, the relative contribution of such immune-related prenatal insults to specific neuropathological outcomes in schizophrenia remains essentially unknown. The study by Ellman et al. is the first to explore whether prenatal levels of the proinflammatory cytokine, IL-8, are associated with the volume of specific brain regions in patients diagnosed with schizophrenia spectrum disorder. The authors provide new data to support a significant association between higher prenatal IL-8 levels in the second/third trimester of pregnancy and greater ventricular cerebrospinal fluid volume in adult schizophrenia spectrum cases. In addition, the results provide evidence for a significant relationship between higher prenatal IL-8 levels and lower volumes in the left entorhinal cortex and right posterior cingulate. The findings provided by Ellman et al., together with the results obtained in other epidemiological studies and experimental animal research, should encourage basic researchers and clinicians alike to make efforts towards the investigation of maternal immunomodulatory interventions that may help alleviate abnormal brain development and long-term psychotic illness in offspring. © 2010 Expert Reviews Ltd.
ISSN	1473-7175 2011 SCImago Journal Rankings: 0.200
DOI	http://dx.doi.org/10.1586/ern.10.169
ISI Accession Number ID	WOS:000288581800009
References	References in Scopus

DC Field	Value
dc.contributor.author	Meyer, U
dc.contributor.author	Weiner, I
dc.contributor.author	McAlonan, GM
dc.contributor.author	Feldon, J
dc.date.accessioned	2011-07-27T01:34:48Z
dc.date.available	2011-07-27T01:34:48Z
dc.date.issued	2011
dc.description.abstract	Maternal infection and/or inflammation during pregnancy has been repeatedly shown to elevate the risk of schizophrenia and related psychotic disorders in offspring. However, the relative contribution of such immune-related prenatal insults to specific neuropathological outcomes in schizophrenia remains essentially unknown. The study by Ellman et al. is the first to explore whether prenatal levels of the proinflammatory cytokine, IL-8, are associated with the volume of specific brain regions in patients diagnosed with schizophrenia spectrum disorder. The authors provide new data to support a significant association between higher prenatal IL-8 levels in the second/third trimester of pregnancy and greater ventricular cerebrospinal fluid volume in adult schizophrenia spectrum cases. In addition, the results provide evidence for a significant relationship between higher prenatal IL-8 levels and lower volumes in the left entorhinal cortex and right posterior cingulate. The findings provided by Ellman et al., together with the results obtained in other epidemiological studies and experimental animal research, should encourage basic researchers and clinicians alike to make efforts towards the investigation of maternal immunomodulatory interventions that may help alleviate abnormal brain development and long-term psychotic illness in offspring. © 2010 Expert Reviews Ltd.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Expert Review Of Neurotherapeutics, 2011, v. 11 n. 1, p. 29-32 [How to Cite?] DOI: http://dx.doi.org/10.1586/ern.10.169
dc.identifier.citeulike	8599475
dc.identifier.doi	http://dx.doi.org/10.1586/ern.10.169
dc.identifier.epage	32
dc.identifier.hkuros	187261
dc.identifier.isi	WOS:000288581800009
dc.identifier.issn	1473-7175 2011 SCImago Journal Rankings: 0.200
dc.identifier.issue	1
dc.identifier.pmid	21158552
dc.identifier.scopus	eid_2-s2.0-78650359084
dc.identifier.spage	29
dc.identifier.uri	http://hdl.handle.net/10722/135406
dc.identifier.volume	11
dc.language	eng
dc.publisher	Expert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/ern
dc.publisher.place	United Kingdom
dc.relation.ispartof	Expert Review of Neurotherapeutics
dc.relation.references	References in Scopus
dc.subject	cerebrospinal fluid
dc.subject	cytokines
dc.subject	enthorinal cortex
dc.subject	hippocampus
dc.subject	immune system
dc.subject	infection
dc.subject	MRI
dc.subject	neurodevelopment
dc.subject	prevention
dc.subject	ventricles
dc.title	The neuropathological contribution of prenatal inflammation to schizophrenia
dc.type	Article

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Author Affiliations

Eidgenossische Technische Hochschule Zurich
The University of Hong Kong
Tel Aviv University

Article: The neuropathological contribution of prenatal inflammation to schizophrenia

The HKU Scholars Hub has contact details for these author(s).