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Article: The neuropathological contribution of prenatal inflammation to schizophrenia

TitleThe neuropathological contribution of prenatal inflammation to schizophrenia
Authors
Keywordscerebrospinal fluid
cytokines
enthorinal cortex
hippocampus
immune system
infection
MRI
neurodevelopment
prevention
ventricles
Issue Date2011
PublisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/ern
Citation
Expert Review Of Neurotherapeutics, 2011, v. 11 n. 1, p. 29-32 How to Cite?
Abstract
Maternal infection and/or inflammation during pregnancy has been repeatedly shown to elevate the risk of schizophrenia and related psychotic disorders in offspring. However, the relative contribution of such immune-related prenatal insults to specific neuropathological outcomes in schizophrenia remains essentially unknown. The study by Ellman et al. is the first to explore whether prenatal levels of the proinflammatory cytokine, IL-8, are associated with the volume of specific brain regions in patients diagnosed with schizophrenia spectrum disorder. The authors provide new data to support a significant association between higher prenatal IL-8 levels in the second/third trimester of pregnancy and greater ventricular cerebrospinal fluid volume in adult schizophrenia spectrum cases. In addition, the results provide evidence for a significant relationship between higher prenatal IL-8 levels and lower volumes in the left entorhinal cortex and right posterior cingulate. The findings provided by Ellman et al., together with the results obtained in other epidemiological studies and experimental animal research, should encourage basic researchers and clinicians alike to make efforts towards the investigation of maternal immunomodulatory interventions that may help alleviate abnormal brain development and long-term psychotic illness in offspring. © 2010 Expert Reviews Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/135406
ISSN
2013 Impact Factor: 2.834
2013 SCImago Journal Rankings: 1.046
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMeyer, Uen_HK
dc.contributor.authorWeiner, Ien_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorFeldon, Jen_HK
dc.date.accessioned2011-07-27T01:34:48Z-
dc.date.available2011-07-27T01:34:48Z-
dc.date.issued2011en_HK
dc.identifier.citationExpert Review Of Neurotherapeutics, 2011, v. 11 n. 1, p. 29-32en_HK
dc.identifier.issn1473-7175en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135406-
dc.description.abstractMaternal infection and/or inflammation during pregnancy has been repeatedly shown to elevate the risk of schizophrenia and related psychotic disorders in offspring. However, the relative contribution of such immune-related prenatal insults to specific neuropathological outcomes in schizophrenia remains essentially unknown. The study by Ellman et al. is the first to explore whether prenatal levels of the proinflammatory cytokine, IL-8, are associated with the volume of specific brain regions in patients diagnosed with schizophrenia spectrum disorder. The authors provide new data to support a significant association between higher prenatal IL-8 levels in the second/third trimester of pregnancy and greater ventricular cerebrospinal fluid volume in adult schizophrenia spectrum cases. In addition, the results provide evidence for a significant relationship between higher prenatal IL-8 levels and lower volumes in the left entorhinal cortex and right posterior cingulate. The findings provided by Ellman et al., together with the results obtained in other epidemiological studies and experimental animal research, should encourage basic researchers and clinicians alike to make efforts towards the investigation of maternal immunomodulatory interventions that may help alleviate abnormal brain development and long-term psychotic illness in offspring. © 2010 Expert Reviews Ltd.en_HK
dc.languageengen_US
dc.publisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/ernen_HK
dc.relation.ispartofExpert Review of Neurotherapeuticsen_HK
dc.subjectcerebrospinal fluiden_HK
dc.subjectcytokinesen_HK
dc.subjectenthorinal cortexen_HK
dc.subjecthippocampusen_HK
dc.subjectimmune systemen_HK
dc.subjectinfectionen_HK
dc.subjectMRIen_HK
dc.subjectneurodevelopmenten_HK
dc.subjectpreventionen_HK
dc.subjectventriclesen_HK
dc.titleThe neuropathological contribution of prenatal inflammation to schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1586/ern.10.169en_HK
dc.identifier.pmid21158552-
dc.identifier.scopuseid_2-s2.0-78650359084en_HK
dc.identifier.hkuros187261en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650359084&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1en_HK
dc.identifier.spage29en_HK
dc.identifier.epage32en_HK
dc.identifier.isiWOS:000288581800009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMeyer, U=35196427300en_HK
dc.identifier.scopusauthoridWeiner, I=7102720633en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridFeldon, J=7102146902en_HK
dc.identifier.citeulike8599475-

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