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- Publisher Website: 10.1586/ern.10.169
- Scopus: eid_2-s2.0-78650359084
- PMID: 21158552
- WOS: WOS:000288581800009
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Article: The neuropathological contribution of prenatal inflammation to schizophrenia
Title | The neuropathological contribution of prenatal inflammation to schizophrenia |
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Authors | |
Keywords | cerebrospinal fluid cytokines enthorinal cortex hippocampus immune system infection MRI neurodevelopment prevention ventricles |
Issue Date | 2011 |
Publisher | Expert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/ern |
Citation | Expert Review Of Neurotherapeutics, 2011, v. 11 n. 1, p. 29-32 How to Cite? |
Abstract | Maternal infection and/or inflammation during pregnancy has been repeatedly shown to elevate the risk of schizophrenia and related psychotic disorders in offspring. However, the relative contribution of such immune-related prenatal insults to specific neuropathological outcomes in schizophrenia remains essentially unknown. The study by Ellman et al. is the first to explore whether prenatal levels of the proinflammatory cytokine, IL-8, are associated with the volume of specific brain regions in patients diagnosed with schizophrenia spectrum disorder. The authors provide new data to support a significant association between higher prenatal IL-8 levels in the second/third trimester of pregnancy and greater ventricular cerebrospinal fluid volume in adult schizophrenia spectrum cases. In addition, the results provide evidence for a significant relationship between higher prenatal IL-8 levels and lower volumes in the left entorhinal cortex and right posterior cingulate. The findings provided by Ellman et al., together with the results obtained in other epidemiological studies and experimental animal research, should encourage basic researchers and clinicians alike to make efforts towards the investigation of maternal immunomodulatory interventions that may help alleviate abnormal brain development and long-term psychotic illness in offspring. © 2010 Expert Reviews Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/135406 |
ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 0.957 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Meyer, U | en_HK |
dc.contributor.author | Weiner, I | en_HK |
dc.contributor.author | McAlonan, GM | en_HK |
dc.contributor.author | Feldon, J | en_HK |
dc.date.accessioned | 2011-07-27T01:34:48Z | - |
dc.date.available | 2011-07-27T01:34:48Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Expert Review Of Neurotherapeutics, 2011, v. 11 n. 1, p. 29-32 | en_HK |
dc.identifier.issn | 1473-7175 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/135406 | - |
dc.description.abstract | Maternal infection and/or inflammation during pregnancy has been repeatedly shown to elevate the risk of schizophrenia and related psychotic disorders in offspring. However, the relative contribution of such immune-related prenatal insults to specific neuropathological outcomes in schizophrenia remains essentially unknown. The study by Ellman et al. is the first to explore whether prenatal levels of the proinflammatory cytokine, IL-8, are associated with the volume of specific brain regions in patients diagnosed with schizophrenia spectrum disorder. The authors provide new data to support a significant association between higher prenatal IL-8 levels in the second/third trimester of pregnancy and greater ventricular cerebrospinal fluid volume in adult schizophrenia spectrum cases. In addition, the results provide evidence for a significant relationship between higher prenatal IL-8 levels and lower volumes in the left entorhinal cortex and right posterior cingulate. The findings provided by Ellman et al., together with the results obtained in other epidemiological studies and experimental animal research, should encourage basic researchers and clinicians alike to make efforts towards the investigation of maternal immunomodulatory interventions that may help alleviate abnormal brain development and long-term psychotic illness in offspring. © 2010 Expert Reviews Ltd. | en_HK |
dc.language | eng | en_US |
dc.publisher | Expert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/ern | en_HK |
dc.relation.ispartof | Expert Review of Neurotherapeutics | en_HK |
dc.subject | cerebrospinal fluid | en_HK |
dc.subject | cytokines | en_HK |
dc.subject | enthorinal cortex | en_HK |
dc.subject | hippocampus | en_HK |
dc.subject | immune system | en_HK |
dc.subject | infection | en_HK |
dc.subject | MRI | en_HK |
dc.subject | neurodevelopment | en_HK |
dc.subject | prevention | en_HK |
dc.subject | ventricles | en_HK |
dc.title | The neuropathological contribution of prenatal inflammation to schizophrenia | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | McAlonan, GM: mcalonan@hkucc.hku.hk | en_HK |
dc.identifier.authority | McAlonan, GM=rp00475 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1586/ern.10.169 | en_HK |
dc.identifier.pmid | 21158552 | - |
dc.identifier.scopus | eid_2-s2.0-78650359084 | en_HK |
dc.identifier.hkuros | 187261 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-78650359084&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 11 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 29 | en_HK |
dc.identifier.epage | 32 | en_HK |
dc.identifier.isi | WOS:000288581800009 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Meyer, U=35196427300 | en_HK |
dc.identifier.scopusauthorid | Weiner, I=7102720633 | en_HK |
dc.identifier.scopusauthorid | McAlonan, GM=6603123011 | en_HK |
dc.identifier.scopusauthorid | Feldon, J=7102146902 | en_HK |
dc.identifier.citeulike | 8599475 | - |
dc.identifier.issnl | 1473-7175 | - |