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Article: The neuropathological contribution of prenatal inflammation to schizophrenia
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TitleThe neuropathological contribution of prenatal inflammation to schizophrenia
 
AuthorsMeyer, U1
Weiner, I3
McAlonan, GM2 2
Feldon, J1
 
Keywordscerebrospinal fluid
cytokines
enthorinal cortex
hippocampus
immune system
infection
MRI
neurodevelopment
prevention
ventricles
 
Issue Date2011
 
PublisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/ern
 
CitationExpert Review Of Neurotherapeutics, 2011, v. 11 n. 1, p. 29-32 [How to Cite?]
DOI: http://dx.doi.org/10.1586/ern.10.169
 
AbstractMaternal infection and/or inflammation during pregnancy has been repeatedly shown to elevate the risk of schizophrenia and related psychotic disorders in offspring. However, the relative contribution of such immune-related prenatal insults to specific neuropathological outcomes in schizophrenia remains essentially unknown. The study by Ellman et al. is the first to explore whether prenatal levels of the proinflammatory cytokine, IL-8, are associated with the volume of specific brain regions in patients diagnosed with schizophrenia spectrum disorder. The authors provide new data to support a significant association between higher prenatal IL-8 levels in the second/third trimester of pregnancy and greater ventricular cerebrospinal fluid volume in adult schizophrenia spectrum cases. In addition, the results provide evidence for a significant relationship between higher prenatal IL-8 levels and lower volumes in the left entorhinal cortex and right posterior cingulate. The findings provided by Ellman et al., together with the results obtained in other epidemiological studies and experimental animal research, should encourage basic researchers and clinicians alike to make efforts towards the investigation of maternal immunomodulatory interventions that may help alleviate abnormal brain development and long-term psychotic illness in offspring. © 2010 Expert Reviews Ltd.
 
ISSN1473-7175
2012 Impact Factor: 2.955
2012 SCImago Journal Rankings: 0.956
 
DOIhttp://dx.doi.org/10.1586/ern.10.169
 
ISI Accession Number IDWOS:000288581800009
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorMeyer, U
 
dc.contributor.authorWeiner, I
 
dc.contributor.authorMcAlonan, GM
 
dc.contributor.authorFeldon, J
 
dc.date.accessioned2011-07-27T01:34:48Z
 
dc.date.available2011-07-27T01:34:48Z
 
dc.date.issued2011
 
dc.description.abstractMaternal infection and/or inflammation during pregnancy has been repeatedly shown to elevate the risk of schizophrenia and related psychotic disorders in offspring. However, the relative contribution of such immune-related prenatal insults to specific neuropathological outcomes in schizophrenia remains essentially unknown. The study by Ellman et al. is the first to explore whether prenatal levels of the proinflammatory cytokine, IL-8, are associated with the volume of specific brain regions in patients diagnosed with schizophrenia spectrum disorder. The authors provide new data to support a significant association between higher prenatal IL-8 levels in the second/third trimester of pregnancy and greater ventricular cerebrospinal fluid volume in adult schizophrenia spectrum cases. In addition, the results provide evidence for a significant relationship between higher prenatal IL-8 levels and lower volumes in the left entorhinal cortex and right posterior cingulate. The findings provided by Ellman et al., together with the results obtained in other epidemiological studies and experimental animal research, should encourage basic researchers and clinicians alike to make efforts towards the investigation of maternal immunomodulatory interventions that may help alleviate abnormal brain development and long-term psychotic illness in offspring. © 2010 Expert Reviews Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationExpert Review Of Neurotherapeutics, 2011, v. 11 n. 1, p. 29-32 [How to Cite?]
DOI: http://dx.doi.org/10.1586/ern.10.169
 
dc.identifier.citeulike8599475
 
dc.identifier.doihttp://dx.doi.org/10.1586/ern.10.169
 
dc.identifier.epage32
 
dc.identifier.hkuros187261
 
dc.identifier.isiWOS:000288581800009
 
dc.identifier.issn1473-7175
2012 Impact Factor: 2.955
2012 SCImago Journal Rankings: 0.956
 
dc.identifier.issue1
 
dc.identifier.pmid21158552
 
dc.identifier.scopuseid_2-s2.0-78650359084
 
dc.identifier.spage29
 
dc.identifier.urihttp://hdl.handle.net/10722/135406
 
dc.identifier.volume11
 
dc.languageeng
 
dc.publisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/ern
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofExpert Review of Neurotherapeutics
 
dc.relation.referencesReferences in Scopus
 
dc.subjectcerebrospinal fluid
 
dc.subjectcytokines
 
dc.subjectenthorinal cortex
 
dc.subjecthippocampus
 
dc.subjectimmune system
 
dc.subjectinfection
 
dc.subjectMRI
 
dc.subjectneurodevelopment
 
dc.subjectprevention
 
dc.subjectventricles
 
dc.titleThe neuropathological contribution of prenatal inflammation to schizophrenia
 
dc.typeArticle
 
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Author Affiliations
  1. Eidgenossische Technische Hochschule Zurich
  2. The University of Hong Kong
  3. Tel Aviv University