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Article: Electroacupuncture for residual insomnia associated with major depressive disorder: A randomized controlled trial

TitleElectroacupuncture for residual insomnia associated with major depressive disorder: A randomized controlled trial
Authors
KeywordsAcupuncture
Electroacupuncture
Insomnia
Major depressive disorder
Randomized controlled trial
Residual insomnia
Issue Date2011
PublisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org
Citation
Sleep, 2011, v. 34 n. 6, p. 807-815 How to Cite?
AbstractStudy Objectives: To evaluate the efficacy and safety of electroacupuncture as an additional treatment for residual insomnia associated with major depressive disorder (MDD). Design: Randomized, placebo-controlled. Setting: A psychiatric outpatient clinic. Participants: 78 Chinese patients with DSM-IV-diagnosed MDD, insomnia complaint, a Hamilton Rating Scale for Depression (HDRS 17) score ≤ 18, and fixed antidepressant dosage. Intervention: Electroacupuncture, minimal acupuncture (superficial needling at non-acupuncture points), or noninvasive placebo acupuncture 3 sessions weekly for 3 weeks. Measurements and Results: Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), HDRS 17, 1 week sleep diaries, and 3 day actigraphy were administered at baseline, 1 week post-treatment, and 4 week post-treatment. There was significant group by time interaction in ISI, PSQI, and sleep diary-derived sleep efficiency (mixed-effects models, P = 0.04, P = 0.03, and P = 0.01, respectively). Post hoc pairwise comparisons revealed that electroacupuncture and minimal acupuncture were more efficacious than placebo acupuncture in ISI and PSQI at 1 week and 4 week post-treatment. Minimal acupuncture resulted in greater improvement in sleep diary-derived sleep efficiency than placebo acupuncture at 1 week post-treatment. There was no significant between-group difference in actigraphy measures, depressive symptoms, daily functioning, and hypnotic consumption, and no difference in any measures between electroacupuncture and minimal acupuncture. Conclusion: Compared with placebo acupuncture, electroacupuncture and minimal acupuncture resulted in greater improvement in subjective sleep measures at 1 week and 4 week post-treatment. No significant difference was found between electroacupuncture and minimal acupuncture, suggesting that the observed differences could be due to nonspecific effects of needling, regardless of whether it is done according to traditional Chinese medicine theory. Clinical Trial Information: Acupuncture for Residual Insomnia Associated with Major Depressive Disorder; Registration #NCT00838994; URL - http://clinicaltrials.gov/ ct2/show/NCT00838994?term = NCT00838994&rank = 1.
Persistent Identifierhttp://hdl.handle.net/10722/135402
ISSN
2015 Impact Factor: 4.793
2015 SCImago Journal Rankings: 2.606
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYeung, WFen_HK
dc.contributor.authorChung, KFen_HK
dc.contributor.authorTso, KCen_HK
dc.contributor.authorZhang, SPen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorHo, LMen_HK
dc.date.accessioned2011-07-27T01:34:45Z-
dc.date.available2011-07-27T01:34:45Z-
dc.date.issued2011en_HK
dc.identifier.citationSleep, 2011, v. 34 n. 6, p. 807-815en_HK
dc.identifier.issn0161-8105en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135402-
dc.description.abstractStudy Objectives: To evaluate the efficacy and safety of electroacupuncture as an additional treatment for residual insomnia associated with major depressive disorder (MDD). Design: Randomized, placebo-controlled. Setting: A psychiatric outpatient clinic. Participants: 78 Chinese patients with DSM-IV-diagnosed MDD, insomnia complaint, a Hamilton Rating Scale for Depression (HDRS 17) score ≤ 18, and fixed antidepressant dosage. Intervention: Electroacupuncture, minimal acupuncture (superficial needling at non-acupuncture points), or noninvasive placebo acupuncture 3 sessions weekly for 3 weeks. Measurements and Results: Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), HDRS 17, 1 week sleep diaries, and 3 day actigraphy were administered at baseline, 1 week post-treatment, and 4 week post-treatment. There was significant group by time interaction in ISI, PSQI, and sleep diary-derived sleep efficiency (mixed-effects models, P = 0.04, P = 0.03, and P = 0.01, respectively). Post hoc pairwise comparisons revealed that electroacupuncture and minimal acupuncture were more efficacious than placebo acupuncture in ISI and PSQI at 1 week and 4 week post-treatment. Minimal acupuncture resulted in greater improvement in sleep diary-derived sleep efficiency than placebo acupuncture at 1 week post-treatment. There was no significant between-group difference in actigraphy measures, depressive symptoms, daily functioning, and hypnotic consumption, and no difference in any measures between electroacupuncture and minimal acupuncture. Conclusion: Compared with placebo acupuncture, electroacupuncture and minimal acupuncture resulted in greater improvement in subjective sleep measures at 1 week and 4 week post-treatment. No significant difference was found between electroacupuncture and minimal acupuncture, suggesting that the observed differences could be due to nonspecific effects of needling, regardless of whether it is done according to traditional Chinese medicine theory. Clinical Trial Information: Acupuncture for Residual Insomnia Associated with Major Depressive Disorder; Registration #NCT00838994; URL - http://clinicaltrials.gov/ ct2/show/NCT00838994?term = NCT00838994&rank = 1.en_HK
dc.languageengen_US
dc.publisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.orgen_HK
dc.relation.ispartofSleepen_HK
dc.subjectAcupunctureen_HK
dc.subjectElectroacupunctureen_HK
dc.subjectInsomniaen_HK
dc.subjectMajor depressive disorderen_HK
dc.subjectRandomized controlled trialen_HK
dc.subjectResidual insomniaen_HK
dc.titleElectroacupuncture for residual insomnia associated with major depressive disorder: A randomized controlled trialen_HK
dc.typeArticleen_HK
dc.identifier.emailChung, KF: kfchung@hkucc.hku.hken_HK
dc.identifier.emailZhang, J: zhangzj@hkucc.hku.hken_HK
dc.identifier.emailHo, LM: lmho@hkucc.hku.hken_HK
dc.identifier.authorityChung, KF=rp00377en_HK
dc.identifier.authorityZhang, J=rp01297en_HK
dc.identifier.authorityHo, LM=rp00360en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.5665/SLEEP.1056en_HK
dc.identifier.pmid21629370-
dc.identifier.pmcidPMC3099500-
dc.identifier.scopuseid_2-s2.0-79957961631en_HK
dc.identifier.hkuros186981en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79957961631&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue6en_HK
dc.identifier.spage807en_HK
dc.identifier.epage815en_HK
dc.identifier.eissn1550-9109-
dc.identifier.isiWOS:000291158000018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYeung, WF=24345897100en_HK
dc.identifier.scopusauthoridChung, KF=7404086681en_HK
dc.identifier.scopusauthoridTso, KC=7003571935en_HK
dc.identifier.scopusauthoridZhang, SP=8056720600en_HK
dc.identifier.scopusauthoridZhang, J=8061473900en_HK
dc.identifier.scopusauthoridHo, LM=7402955625en_HK

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