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Article: Heritability of Serum Osteoprotegerin

TitleHeritability of Serum Osteoprotegerin
Authors
KeywordsHeritability
Osteoprotegerin
Variance component
Issue Date2011
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHG
Citation
Annals Of Human Genetics, 2011, v. 75 n. 5, p. 584-588 How to Cite?
Abstract
Serum osteoprotegerin (OPG) level is a key biomarker for numerous traits of clinical importance like diabetes, coronary artery disease, blood pressure, lipid profile, and cancers, but its genetic basis remains poorly understood. We estimated the heritability (h 2) of serum OPG level in 1442 southern Chinese subjects from 306 families. The h 2 for unadjusted OPG was 0.62 for females and 0.17 for males; and for age-adjusted OPG, 0.75 for females and 0.37 for males. Adjustment for lifestyle factors including calcium and phytoestrogen intake, exercise, smoking, and alcohol consumption exerted only a modest effect on the h 2. In conclusion, we confirmed that circulating OPG is a heritable trait and there is a significant difference in heritability between sexes. © 2011 The Authors, Annals of Human Genetics © 2011 Blackwell Publishing Ltd/University College London.
Persistent Identifierhttp://hdl.handle.net/10722/135397
ISSN
2013 Impact Factor: 1.926
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Osteoporosis Research Fund
University Research Committee
Centre for Reproduction, Development, and Growth Research Grant of the Faculty of Medicine, the University of Hong Kong
KC Wong Education Foundation
Funding Information:

PCS received funding support from the Genomics Strategic Research Theme of the University of Hong Kong. The study was supported by the Osteoporosis Research Fund, the PDF matching fund scheme of the University Research Committee, the University of Hong Kong, and the Centre for Reproduction, Development, and Growth Research Grant of the Faculty of Medicine, the University of Hong Kong. Sumei Xiao is partly supported by the KC Wong Education Foundation. The authors would also like to thank all the participants in this study.

References

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorKwan, JSHen_HK
dc.contributor.authorXiao, Sen_HK
dc.contributor.authorBow, Cen_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorSoong, Cen_HK
dc.contributor.authorLau, KSen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2011-07-27T01:34:43Z-
dc.date.available2011-07-27T01:34:43Z-
dc.date.issued2011en_HK
dc.identifier.citationAnnals Of Human Genetics, 2011, v. 75 n. 5, p. 584-588en_HK
dc.identifier.issn0003-4800en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135397-
dc.description.abstractSerum osteoprotegerin (OPG) level is a key biomarker for numerous traits of clinical importance like diabetes, coronary artery disease, blood pressure, lipid profile, and cancers, but its genetic basis remains poorly understood. We estimated the heritability (h 2) of serum OPG level in 1442 southern Chinese subjects from 306 families. The h 2 for unadjusted OPG was 0.62 for females and 0.17 for males; and for age-adjusted OPG, 0.75 for females and 0.37 for males. Adjustment for lifestyle factors including calcium and phytoestrogen intake, exercise, smoking, and alcohol consumption exerted only a modest effect on the h 2. In conclusion, we confirmed that circulating OPG is a heritable trait and there is a significant difference in heritability between sexes. © 2011 The Authors, Annals of Human Genetics © 2011 Blackwell Publishing Ltd/University College London.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHGen_HK
dc.relation.ispartofAnnals of Human Geneticsen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectHeritabilityen_HK
dc.subjectOsteoprotegerinen_HK
dc.subjectVariance componenten_HK
dc.subject.meshAdult-
dc.subject.meshAsian Continental Ancestry Group-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshOsteoprotegerin - blood - genetics-
dc.titleHeritability of Serum Osteoprotegerinen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, CL: lung1212@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityCheung, CL=rp01749en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1469-1809.2011.00661.xen_HK
dc.identifier.pmid21762114en_HK
dc.identifier.scopuseid_2-s2.0-80051557252en_HK
dc.identifier.hkuros186064en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80051557252&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume75en_HK
dc.identifier.issue5en_HK
dc.identifier.spage584en_HK
dc.identifier.epage588en_HK
dc.identifier.isiWOS:000293792100004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKwan, JSH=37063349600en_HK
dc.identifier.scopusauthoridXiao, S=7402022586en_HK
dc.identifier.scopusauthoridBow, C=36055977600en_HK
dc.identifier.scopusauthoridCheung, CL=14520953400en_HK
dc.identifier.scopusauthoridSoong, C=36769165800en_HK
dc.identifier.scopusauthoridLau, KS=35205833900en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.citeulike9688489-

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