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Article: Heritability of Serum Osteoprotegerin
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TitleHeritability of Serum Osteoprotegerin
 
AuthorsKwan, JSH1
Xiao, S1
Bow, C1
Cheung, CL1
Soong, C1
Lau, KS1
Sham, PC1
Kung, AWC1
 
KeywordsHeritability
Osteoprotegerin
Variance component
 
Issue Date2011
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHG
 
CitationAnnals Of Human Genetics, 2011, v. 75 n. 5, p. 584-588 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1469-1809.2011.00661.x
 
AbstractSerum osteoprotegerin (OPG) level is a key biomarker for numerous traits of clinical importance like diabetes, coronary artery disease, blood pressure, lipid profile, and cancers, but its genetic basis remains poorly understood. We estimated the heritability (h 2) of serum OPG level in 1442 southern Chinese subjects from 306 families. The h 2 for unadjusted OPG was 0.62 for females and 0.17 for males; and for age-adjusted OPG, 0.75 for females and 0.37 for males. Adjustment for lifestyle factors including calcium and phytoestrogen intake, exercise, smoking, and alcohol consumption exerted only a modest effect on the h 2. In conclusion, we confirmed that circulating OPG is a heritable trait and there is a significant difference in heritability between sexes. © 2011 The Authors, Annals of Human Genetics © 2011 Blackwell Publishing Ltd/University College London.
 
ISSN0003-4800
2013 Impact Factor: 1.926
 
DOIhttp://dx.doi.org/10.1111/j.1469-1809.2011.00661.x
 
ISI Accession Number IDWOS:000293792100004
Funding AgencyGrant Number
University of Hong Kong
Osteoporosis Research Fund
University Research Committee
Centre for Reproduction, Development, and Growth Research Grant of the Faculty of Medicine, the University of Hong Kong
KC Wong Education Foundation
Funding Information:

PCS received funding support from the Genomics Strategic Research Theme of the University of Hong Kong. The study was supported by the Osteoporosis Research Fund, the PDF matching fund scheme of the University Research Committee, the University of Hong Kong, and the Centre for Reproduction, Development, and Growth Research Grant of the Faculty of Medicine, the University of Hong Kong. Sumei Xiao is partly supported by the KC Wong Education Foundation. The authors would also like to thank all the participants in this study.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorKwan, JSH
 
dc.contributor.authorXiao, S
 
dc.contributor.authorBow, C
 
dc.contributor.authorCheung, CL
 
dc.contributor.authorSoong, C
 
dc.contributor.authorLau, KS
 
dc.contributor.authorSham, PC
 
dc.contributor.authorKung, AWC
 
dc.date.accessioned2011-07-27T01:34:43Z
 
dc.date.available2011-07-27T01:34:43Z
 
dc.date.issued2011
 
dc.description.abstractSerum osteoprotegerin (OPG) level is a key biomarker for numerous traits of clinical importance like diabetes, coronary artery disease, blood pressure, lipid profile, and cancers, but its genetic basis remains poorly understood. We estimated the heritability (h 2) of serum OPG level in 1442 southern Chinese subjects from 306 families. The h 2 for unadjusted OPG was 0.62 for females and 0.17 for males; and for age-adjusted OPG, 0.75 for females and 0.37 for males. Adjustment for lifestyle factors including calcium and phytoestrogen intake, exercise, smoking, and alcohol consumption exerted only a modest effect on the h 2. In conclusion, we confirmed that circulating OPG is a heritable trait and there is a significant difference in heritability between sexes. © 2011 The Authors, Annals of Human Genetics © 2011 Blackwell Publishing Ltd/University College London.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationAnnals Of Human Genetics, 2011, v. 75 n. 5, p. 584-588 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1469-1809.2011.00661.x
 
dc.identifier.citeulike9688489
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1469-1809.2011.00661.x
 
dc.identifier.epage588
 
dc.identifier.hkuros186064
 
dc.identifier.isiWOS:000293792100004
Funding AgencyGrant Number
University of Hong Kong
Osteoporosis Research Fund
University Research Committee
Centre for Reproduction, Development, and Growth Research Grant of the Faculty of Medicine, the University of Hong Kong
KC Wong Education Foundation
Funding Information:

PCS received funding support from the Genomics Strategic Research Theme of the University of Hong Kong. The study was supported by the Osteoporosis Research Fund, the PDF matching fund scheme of the University Research Committee, the University of Hong Kong, and the Centre for Reproduction, Development, and Growth Research Grant of the Faculty of Medicine, the University of Hong Kong. Sumei Xiao is partly supported by the KC Wong Education Foundation. The authors would also like to thank all the participants in this study.

 
dc.identifier.issn0003-4800
2013 Impact Factor: 1.926
 
dc.identifier.issue5
 
dc.identifier.pmid21762114
 
dc.identifier.scopuseid_2-s2.0-80051557252
 
dc.identifier.spage584
 
dc.identifier.urihttp://hdl.handle.net/10722/135397
 
dc.identifier.volume75
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHG
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofAnnals of Human Genetics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www.blackwell-synergy.com
 
dc.subject.meshAdult
 
dc.subject.meshAsian Continental Ancestry Group
 
dc.subject.meshHumans
 
dc.subject.meshMiddle Aged
 
dc.subject.meshOsteoprotegerin - blood - genetics
 
dc.subjectHeritability
 
dc.subjectOsteoprotegerin
 
dc.subjectVariance component
 
dc.titleHeritability of Serum Osteoprotegerin
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong