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Article: Kaempferol enhances endothelium-independent and dependent relaxation in the porcine coronary artery

TitleKaempferol enhances endothelium-independent and dependent relaxation in the porcine coronary artery
Authors
KeywordsAntioxidant
Flavonoid
Kaempferol
Relaxation
Smooth muscle
Issue Date2006
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
Citation
Molecular And Cellular Biochemistry, 2006, v. 287 n. 1-2, p. 61-67 How to Cite?
AbstractThe vascular effects of kaempferol were investigated in isolated porcine coronary artery rings. U46619 (9,11-dideoxy-9α, 11α-methanoepoxy prostaglandin F2α, 30 nM) was used to contract porcine coronary arterial rings. Concentration relaxation curve of kaempferol (1 nM - 100 μM) was constructed and kaempferol demonstrated significant relaxation at high concentrations. At low concentration with no significant effect on relaxation, kaempferol (10 μM) enhanced relaxation produced by bradykinin, the calcium ionophore A23187, isoproterenol and sodium nitroprusside in endothelium-intact porcine coronary arteries. In endothelium-disrupt rings, kaempferol (10 μM) also enhanced the relaxation caused by isoproterenol, sodium nitroprusside, levcromakalim and nifedipine. On the other hand, antioxidant agents did not affect bradykinin-induced relaxation or the enhancement effect of kaempferol. In summary, a low concentration of kaempferol (10 μM), devoid of significant vascular effect, has the ability to enhance endothelium-dependent and endothelium-independent relaxations. This action of kaempferol is unrelated to its antioxidant property. © Springer Science+Business Media, Inc. 2006.
Persistent Identifierhttp://hdl.handle.net/10722/135352
ISSN
2015 Impact Factor: 2.613
2015 SCImago Journal Rankings: 1.019
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, YCen_HK
dc.contributor.authorYeung, DKYen_HK
dc.contributor.authorMan, RYKen_HK
dc.contributor.authorLeung, SWSen_HK
dc.date.accessioned2011-07-27T01:33:58Z-
dc.date.available2011-07-27T01:33:58Z-
dc.date.issued2006en_HK
dc.identifier.citationMolecular And Cellular Biochemistry, 2006, v. 287 n. 1-2, p. 61-67en_HK
dc.identifier.issn0300-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135352-
dc.description.abstractThe vascular effects of kaempferol were investigated in isolated porcine coronary artery rings. U46619 (9,11-dideoxy-9α, 11α-methanoepoxy prostaglandin F2α, 30 nM) was used to contract porcine coronary arterial rings. Concentration relaxation curve of kaempferol (1 nM - 100 μM) was constructed and kaempferol demonstrated significant relaxation at high concentrations. At low concentration with no significant effect on relaxation, kaempferol (10 μM) enhanced relaxation produced by bradykinin, the calcium ionophore A23187, isoproterenol and sodium nitroprusside in endothelium-intact porcine coronary arteries. In endothelium-disrupt rings, kaempferol (10 μM) also enhanced the relaxation caused by isoproterenol, sodium nitroprusside, levcromakalim and nifedipine. On the other hand, antioxidant agents did not affect bradykinin-induced relaxation or the enhancement effect of kaempferol. In summary, a low concentration of kaempferol (10 μM), devoid of significant vascular effect, has the ability to enhance endothelium-dependent and endothelium-independent relaxations. This action of kaempferol is unrelated to its antioxidant property. © Springer Science+Business Media, Inc. 2006.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177en_HK
dc.relation.ispartofMolecular and Cellular Biochemistryen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectAntioxidanten_HK
dc.subjectFlavonoiden_HK
dc.subjectKaempferolen_HK
dc.subjectRelaxationen_HK
dc.subjectSmooth muscleen_HK
dc.subject.meshAntioxidants - pharmacology-
dc.subject.meshCoronary Vessels - drug effects - physiology-
dc.subject.meshEndothelium, Vascular-
dc.subject.meshKaempferols - pharmacology-
dc.subject.meshVasodilation - drug effects-
dc.titleKaempferol enhances endothelium-independent and dependent relaxation in the porcine coronary arteryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-8177&volume=287&issue=1-2&spage=61&epage=67&date=2006&atitle=Kaempferol+enhances+endothelium-independent+and+dependent+relaxation+in+the+porcine+coronary+artery-
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.emailLeung, SWS: swsleung@hku.hken_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11010-005-9061-yen_HK
dc.identifier.pmid16699727-
dc.identifier.scopuseid_2-s2.0-33745937103en_HK
dc.identifier.hkuros187144en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745937103&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume287en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage61en_HK
dc.identifier.epage67en_HK
dc.identifier.isiWOS:000239022600007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXu, YC=49764337900en_HK
dc.identifier.scopusauthoridYeung, DKY=16176892200en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK
dc.identifier.scopusauthoridLeung, SWS=24540419500en_HK

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