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Article: Efficacy of different vasodilators on human umbilical arterial smooth muscle under normal and reduced oxygen conditions

TitleEfficacy of different vasodilators on human umbilical arterial smooth muscle under normal and reduced oxygen conditions
Authors
KeywordsCalcium channel antagonist
Human umbilical arteries
Nitric oxide
Potassium channel opener
Vasodilation
Issue Date2006
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/earlhumdev
Citation
Early Human Development, 2006, v. 82 n. 7, p. 457-462 How to Cite?
AbstractThe ability of the smooth muscle of the human umbilical artery to relax may vary under physiological and pathological conditions. We investigated the responsiveness of that preparation to relaxation, as well as the influence of reduced oxygen condition on these responses. Rings of human umbilical arteries from full-term Caesarian deliveries were suspended in modified Krebs-Henseleit solutions bubbled with a gas mixture of 95% O2 : 5% CO2 (normal oxygen condition) or 2.5% O2 : 8% CO2 balanced with N2 (reduced oxygen condition). These rings were contracted with potassium chloride, serotonin or the thromboxane A2 mimetic U46619, before being exposed to either the nitrovasodilator sodium nitroprusside, the potassium channel opener levcromakalim or the calcium channel antagonist amlodipine. While sodium nitroprusside elicited relaxation in this blood vessel, the maximal relaxation to the nitric oxide donor was significantly smaller than that induced by levcromakalim and amlodipine. The nature of the constrictor agent used, or changes of oxygen conditions did not significantly affect the relaxation profile of this human blood vessel. These data suggest that the smooth muscle of the human umbilical artery may be less responsive to vasodilators that act via the nitric oxide pathway. Moreover, vascular responses of umbilical arterial smooth muscle to relaxing agents do not alter under hypoxic or different vasoconstricting conditions. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/135350
ISSN
2015 Impact Factor: 1.913
2015 SCImago Journal Rankings: 0.932
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorQuan, Aen_HK
dc.contributor.authorLao, TTen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2011-07-27T01:33:57Z-
dc.date.available2011-07-27T01:33:57Z-
dc.date.issued2006en_HK
dc.identifier.citationEarly Human Development, 2006, v. 82 n. 7, p. 457-462en_HK
dc.identifier.issn0378-3782en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135350-
dc.description.abstractThe ability of the smooth muscle of the human umbilical artery to relax may vary under physiological and pathological conditions. We investigated the responsiveness of that preparation to relaxation, as well as the influence of reduced oxygen condition on these responses. Rings of human umbilical arteries from full-term Caesarian deliveries were suspended in modified Krebs-Henseleit solutions bubbled with a gas mixture of 95% O2 : 5% CO2 (normal oxygen condition) or 2.5% O2 : 8% CO2 balanced with N2 (reduced oxygen condition). These rings were contracted with potassium chloride, serotonin or the thromboxane A2 mimetic U46619, before being exposed to either the nitrovasodilator sodium nitroprusside, the potassium channel opener levcromakalim or the calcium channel antagonist amlodipine. While sodium nitroprusside elicited relaxation in this blood vessel, the maximal relaxation to the nitric oxide donor was significantly smaller than that induced by levcromakalim and amlodipine. The nature of the constrictor agent used, or changes of oxygen conditions did not significantly affect the relaxation profile of this human blood vessel. These data suggest that the smooth muscle of the human umbilical artery may be less responsive to vasodilators that act via the nitric oxide pathway. Moreover, vascular responses of umbilical arterial smooth muscle to relaxing agents do not alter under hypoxic or different vasoconstricting conditions. © 2005 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/earlhumdeven_HK
dc.relation.ispartofEarly Human Developmenten_HK
dc.subjectCalcium channel antagonisten_HK
dc.subjectHuman umbilical arteriesen_HK
dc.subjectNitric oxideen_HK
dc.subjectPotassium channel openeren_HK
dc.subjectVasodilationen_HK
dc.subject.meshAnoxia - physiopathology-
dc.subject.meshMuscle, Smooth, Vascular - drug effects - physiopathology-
dc.subject.meshUmbilical Arteries - drug effects - physiopathology-
dc.subject.meshVasodilation - drug effects - physiology-
dc.subject.meshVasodilator Agents - pharmacology-
dc.titleEfficacy of different vasodilators on human umbilical arterial smooth muscle under normal and reduced oxygen conditionsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0378-3782&volume=82&issue=7&spage=457&epage=462&date=2006&atitle=Efficacy+of+different+vasodilators+on+human+umbilical+arterial+smooth+muscle+under+normal+and+reduced+oxygen+conditions-
dc.identifier.emailLeung, SWS: swsleung@hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.earlhumdev.2005.11.009en_HK
dc.identifier.pmid16443336-
dc.identifier.scopuseid_2-s2.0-33745495055en_HK
dc.identifier.hkuros187138en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745495055&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume82en_HK
dc.identifier.issue7en_HK
dc.identifier.spage457en_HK
dc.identifier.epage462en_HK
dc.identifier.isiWOS:000239465300006-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLeung, SWS=24540419500en_HK
dc.identifier.scopusauthoridQuan, A=7006871453en_HK
dc.identifier.scopusauthoridLao, TT=35275381600en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK

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