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Article: A synopsis of current haemophilia care in Hong Kong
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TitleA synopsis of current haemophilia care in Hong Kong
 
AuthorsAu, WY8
Lee, V5
Kho, B
Ling, ASC2
Chan, D7
Chan, EYT1
Chan, GCF8
Cheung, WWW8
Lau, CW3
Lee, CY9
Li, RCH3
Li, CK5
Lin, SY7
Mak, V2
Sun, L6
Wong, KHF4
Wong, R5
Yau, J4
Yuen, HL4
 
KeywordsFactor VIII
Hemophilia A
HIV infections
Mutation
Survival rate
 
Issue Date2011
 
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
 
CitationHong Kong Medical Journal, 2011, v. 17 n. 3, p. 189-194 [How to Cite?]
 
AbstractObjective To provide a synopsis of current haemophilia care in Hong Kong. Design Retrospective survey. Setting All haematology units of the Hospital Authority in Hong Kong. Patients All patients with haemophilia A and haemophilia B. Results To date, there were 222 mild-to-severe haemophilia patients (192 type A, 30 type B) under regular public care in Hong Kong (43% were considered severe, 33% moderate, and 24% mild), which gave a crude prevalence of 6.8/100 000 male inhabitants. A total of 12.8 million units of Factor VIII and 3 million units of Factor IX were prescribed annually. This amounts to 1.83 units of FVIII per capita of the population, which is comparable to that of other developed countries. Leading causes of mortality were human immunodefciency virus-related complications (10 cases) and cerebral bleeding (2 cases). The life expectancy of patients with severe haemophilia in Hong Kong is improving; currently the oldest patient is 60 years old. Such improved survival may be due to enhanced factor availability, prompt treatment of bleeding episodes at home, safer factor products, and better antiviral treatment. Primary prophylaxis is the accepted standard of care for severe and moderate cases, and "Factor First" has become hospital policy. However, 12 patients continue to present treatment challenges, due to the documented presence of factor inhibitors. In all, 28,100, and 14 cases respectively were positive for human immunodefciency virus, hepatitis C virus, and hepatitis B virus; the youngest patients with the corresponding infections being 28,13, and 22 years old. Comprehensive care with dedicated physiotherapy, surgical support, and radionucleotide synovectomy may reduce morbidity further. Conclusion A multidisciplinary approach can further improve the future care for haemophilia patients in Hong Kong.
 
DescriptionAuthor Chinese names: WY Au 區永仁, Vincent Lee 李偉生, Bonnie Kho 許紫珊, Alvin SC Ling 凌紹祥, Desmond Chan 陳振榮, Eric YT Chan 陳日東, Godfrey CF Chan 陳志峯, Winnie WW Cheung 張永慧, CW Lau 劉靜華, CY Lee 李靜賢, Rever CH Li 李澤荷, CK Li 李志光, SY Lin 連錫營, Vivien Mak 麥慧敏, Lina Sun 孫偉芬, Kris HF Wong 黃鴻勳, Raymond Wong 王紹明, Jeffrey Yau 丘炳華, HL Yuen 袁煦樑
 
ISSN1024-2708
2012 SCImago Journal Rankings: 0.255
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorAu, WY
 
dc.contributor.authorLee, V
 
dc.contributor.authorKho, B
 
dc.contributor.authorLing, ASC
 
dc.contributor.authorChan, D
 
dc.contributor.authorChan, EYT
 
dc.contributor.authorChan, GCF
 
dc.contributor.authorCheung, WWW
 
dc.contributor.authorLau, CW
 
dc.contributor.authorLee, CY
 
dc.contributor.authorLi, RCH
 
dc.contributor.authorLi, CK
 
dc.contributor.authorLin, SY
 
dc.contributor.authorMak, V
 
dc.contributor.authorSun, L
 
dc.contributor.authorWong, KHF
 
dc.contributor.authorWong, R
 
dc.contributor.authorYau, J
 
dc.contributor.authorYuen, HL
 
dc.date.accessioned2011-07-27T01:33:44Z
 
dc.date.available2011-07-27T01:33:44Z
 
dc.date.issued2011
 
dc.description.abstractObjective To provide a synopsis of current haemophilia care in Hong Kong. Design Retrospective survey. Setting All haematology units of the Hospital Authority in Hong Kong. Patients All patients with haemophilia A and haemophilia B. Results To date, there were 222 mild-to-severe haemophilia patients (192 type A, 30 type B) under regular public care in Hong Kong (43% were considered severe, 33% moderate, and 24% mild), which gave a crude prevalence of 6.8/100 000 male inhabitants. A total of 12.8 million units of Factor VIII and 3 million units of Factor IX were prescribed annually. This amounts to 1.83 units of FVIII per capita of the population, which is comparable to that of other developed countries. Leading causes of mortality were human immunodefciency virus-related complications (10 cases) and cerebral bleeding (2 cases). The life expectancy of patients with severe haemophilia in Hong Kong is improving; currently the oldest patient is 60 years old. Such improved survival may be due to enhanced factor availability, prompt treatment of bleeding episodes at home, safer factor products, and better antiviral treatment. Primary prophylaxis is the accepted standard of care for severe and moderate cases, and "Factor First" has become hospital policy. However, 12 patients continue to present treatment challenges, due to the documented presence of factor inhibitors. In all, 28,100, and 14 cases respectively were positive for human immunodefciency virus, hepatitis C virus, and hepatitis B virus; the youngest patients with the corresponding infections being 28,13, and 22 years old. Comprehensive care with dedicated physiotherapy, surgical support, and radionucleotide synovectomy may reduce morbidity further. Conclusion A multidisciplinary approach can further improve the future care for haemophilia patients in Hong Kong.
 
dc.description.naturepublished_or_final_version
 
dc.descriptionAuthor Chinese names: WY Au 區永仁, Vincent Lee 李偉生, Bonnie Kho 許紫珊, Alvin SC Ling 凌紹祥, Desmond Chan 陳振榮, Eric YT Chan 陳日東, Godfrey CF Chan 陳志峯, Winnie WW Cheung 張永慧, CW Lau 劉靜華, CY Lee 李靜賢, Rever CH Li 李澤荷, CK Li 李志光, SY Lin 連錫營, Vivien Mak 麥慧敏, Lina Sun 孫偉芬, Kris HF Wong 黃鴻勳, Raymond Wong 王紹明, Jeffrey Yau 丘炳華, HL Yuen 袁煦樑
 
dc.identifier.citationHong Kong Medical Journal, 2011, v. 17 n. 3, p. 189-194 [How to Cite?]
 
dc.identifier.epage194
 
dc.identifier.hkuros187929
 
dc.identifier.issn1024-2708
2012 SCImago Journal Rankings: 0.255
 
dc.identifier.issue3
 
dc.identifier.pmid21636866
 
dc.identifier.scopuseid_2-s2.0-79958745818
 
dc.identifier.spage189
 
dc.identifier.urihttp://hdl.handle.net/10722/135337
 
dc.identifier.volume17
 
dc.languageeng
 
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofHong Kong Medical Journal
 
dc.relation.referencesReferences in Scopus
 
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshCoagulants - therapeutic use
 
dc.subject.meshFactor IX - therapeutic use
 
dc.subject.meshFactor VIII - therapeutic use
 
dc.subject.meshHemophilia A - epidemiology - physiopathology - therapy
 
dc.subject.meshHemophilia B - epidemiology - physiopathology - therapy
 
dc.subjectFactor VIII
 
dc.subjectHemophilia A
 
dc.subjectHIV infections
 
dc.subjectMutation
 
dc.subjectSurvival rate
 
dc.titleA synopsis of current haemophilia care in Hong Kong
 
dc.typeArticle
 
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<contributor.author>Lee, V</contributor.author>
<contributor.author>Kho, B</contributor.author>
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<contributor.author>Chan, D</contributor.author>
<contributor.author>Chan, EYT</contributor.author>
<contributor.author>Chan, GCF</contributor.author>
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<description.abstract>Objective To provide a synopsis of current haemophilia care in Hong Kong. Design Retrospective survey. Setting All haematology units of the Hospital Authority in Hong Kong. Patients All patients with haemophilia A and haemophilia B. Results To date, there were 222 mild-to-severe haemophilia patients (192 type A, 30 type B) under regular public care in Hong Kong (43% were considered severe, 33% moderate, and 24% mild), which gave a crude prevalence of 6.8/100 000 male inhabitants. A total of 12.8 million units of Factor VIII and 3 million units of Factor IX were prescribed annually. This amounts to 1.83 units of FVIII per capita of the population, which is comparable to that of other developed countries. Leading causes of mortality were human immunodefciency virus-related complications (10 cases) and cerebral bleeding (2 cases). The life expectancy of patients with severe haemophilia in Hong Kong is improving; currently the oldest patient is 60 years old. Such improved survival may be due to enhanced factor availability, prompt treatment of bleeding episodes at home, safer factor products, and better antiviral treatment. Primary prophylaxis is the accepted standard of care for severe and moderate cases, and &quot;Factor First&quot; has become hospital policy. However, 12 patients continue to present treatment challenges, due to the documented presence of factor inhibitors. In all, 28,100, and 14 cases respectively were positive for human immunodefciency virus, hepatitis C virus, and hepatitis B virus; the youngest patients with the corresponding infections being 28,13, and 22 years old. Comprehensive care with dedicated physiotherapy, surgical support, and radionucleotide synovectomy may reduce morbidity further. Conclusion A multidisciplinary approach can further improve the future care for haemophilia patients in Hong Kong.</description.abstract>
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<subject>Factor VIII</subject>
<subject>Hemophilia A</subject>
<subject>HIV infections</subject>
<subject>Mutation</subject>
<subject>Survival rate</subject>
<subject.mesh>Coagulants - therapeutic use</subject.mesh>
<subject.mesh>Factor IX - therapeutic use</subject.mesh>
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Author Affiliations
  1. Kwong Wah Hospital
  2. Princess Margaret Hospital Hong Kong
  3. Tuen Mun Hospital
  4. Queen Elizabeth Hospital Hong Kong
  5. Prince of Wales Hospital Hong Kong
  6. Pamela Youde Nethersole Eastern Hospital
  7. United Christian Hospital Hong Kong
  8. Queen Mary Hospital Hong Kong
  9. Caritas Medical Centre Hong Kong