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Article: Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009

TitleSerotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009
Authors
KeywordsDrug resistance
Heptavalent pneumococcal conjugate vaccine
Serotype replacement
Streptococcus pneumoniae
Issue Date2011
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
Citation
Vaccine, 2011, v. 29 n. 17, p. 3270-3275 How to Cite?
AbstractThis study analyzed 828 isolates causing invasive pneumococcal disease (IPD) before (1995-2001, n=265) and after (2007-2009, n=563) the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in Hong Kong. In children <5 years, serotype 14 had declined (36-15.7%, P<0.01) while 19A had increased (0-12.9%, P<0.01) in the before and after periods, respectively. In children aged <5 years, the proportion of PCV7 serotypes declined from 89.5% to 65.7% (72.8% if included cross protection against 6A) with time but that of PCV13 serotypes remained stable (91.4-93.2%). In elderly ≥65 years, 9V and 23F decreased from 3.8% to 0.3% (P=0.01) and from 18.9% to 7.4% (P <0.01), respectively while 7F increased significantly from 0% to 4.1% (P=0.04) over the same periods. Among isolates from aged <5 years, dual penicillin/erythromycin resistance increased from 44.1% to 64.2% (P=0.01). The types that often had dual penicillin/erythromycin resistance were 6B, 14, 19F, 23F, 6A and 19A. The emergence of serotype 19A was associated with expansion of sequence type 320. © 2011 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/135336
ISSN
2014 Impact Factor: 3.624
2014 SCImago Journal Rankings: 1.740
ISI Accession Number ID
Funding AgencyGrant Number
Food and Health Bureau of the Hong Kong SAR Government
Funding Information:

This study is supported by research grants from the Research Fund for the Control of Infectious Diseases of the Food and Health Bureau of the Hong Kong SAR Government. Authors had no conflict of interest to declare.

References

 

DC FieldValueLanguage
dc.contributor.authorHo, PLen_HK
dc.contributor.authorChiu, SSen_HK
dc.contributor.authorAng, Ien_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2011-07-27T01:33:42Z-
dc.date.available2011-07-27T01:33:42Z-
dc.date.issued2011en_HK
dc.identifier.citationVaccine, 2011, v. 29 n. 17, p. 3270-3275en_HK
dc.identifier.issn0264-410Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/135336-
dc.description.abstractThis study analyzed 828 isolates causing invasive pneumococcal disease (IPD) before (1995-2001, n=265) and after (2007-2009, n=563) the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in Hong Kong. In children <5 years, serotype 14 had declined (36-15.7%, P<0.01) while 19A had increased (0-12.9%, P<0.01) in the before and after periods, respectively. In children aged <5 years, the proportion of PCV7 serotypes declined from 89.5% to 65.7% (72.8% if included cross protection against 6A) with time but that of PCV13 serotypes remained stable (91.4-93.2%). In elderly ≥65 years, 9V and 23F decreased from 3.8% to 0.3% (P=0.01) and from 18.9% to 7.4% (P <0.01), respectively while 7F increased significantly from 0% to 4.1% (P=0.04) over the same periods. Among isolates from aged <5 years, dual penicillin/erythromycin resistance increased from 44.1% to 64.2% (P=0.01). The types that often had dual penicillin/erythromycin resistance were 6B, 14, 19F, 23F, 6A and 19A. The emergence of serotype 19A was associated with expansion of sequence type 320. © 2011 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccineen_HK
dc.relation.ispartofVaccineen_HK
dc.subjectDrug resistanceen_HK
dc.subjectHeptavalent pneumococcal conjugate vaccineen_HK
dc.subjectSerotype replacementen_HK
dc.subjectStreptococcus pneumoniaeen_HK
dc.subject.meshAnti-Bacterial Agents - pharmacology-
dc.subject.meshBacterial Typing Techniques-
dc.subject.meshPneumococcal Infections - epidemiology - microbiology-
dc.subject.meshPneumococcal Vaccines - administration and dosage - immunology-
dc.subject.meshStreptococcus pneumoniae - classification - drug effects - immunology - isolation and purification-
dc.titleSerotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0264-410X&volume=29&issue=17&spage=3270&epage=3275&date=2011&atitle=Serotypes+and+antimicrobial+susceptibilities+of+invasive+Streptococcus+pneumoniae+before+and+after+introduction+of+7-valent+pneumococcal+conjugate+vaccine,+Hong+Kong,+1995-2009-
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailChiu, SS:ssschiu@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityChiu, SS=rp00421en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.vaccine.2011.02.025en_HK
dc.identifier.pmid21352937-
dc.identifier.scopuseid_2-s2.0-79954603483en_HK
dc.identifier.hkuros187585en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79954603483&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue17en_HK
dc.identifier.spage3270en_HK
dc.identifier.epage3275en_HK
dc.identifier.eissn1873-2518-
dc.identifier.isiWOS:000290603100027-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridChiu, SS=7202291500en_HK
dc.identifier.scopusauthoridAng, I=55214129400en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.citeulike8888203-

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