Article: Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009
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- Publisher Website: 10.1016/j.vaccine.2011.02.025
- Scopus: eid_2-s2.0-79954603483
- PMID: 21352937
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| Title | Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009 |
|---|---|
| Authors | Ho, PL1 Chiu, SS1 Ang, I1 Lau, YL1 |
| Keywords | Drug resistance Heptavalent pneumococcal conjugate vaccine Serotype replacement Streptococcus pneumoniae |
| Issue Date | 2011 |
| Publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine |
| Citation | Vaccine, 2011, v. 29 n. 17, p. 3270-3275 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.vaccine.2011.02.025 |
| Abstract | This study analyzed 828 isolates causing invasive pneumococcal disease (IPD) before (1995-2001, n=265) and after (2007-2009, n=563) the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in Hong Kong. In children <5 years, serotype 14 had declined (36-15.7%, P<0.01) while 19A had increased (0-12.9%, P<0.01) in the before and after periods, respectively. In children aged <5 years, the proportion of PCV7 serotypes declined from 89.5% to 65.7% (72.8% if included cross protection against 6A) with time but that of PCV13 serotypes remained stable (91.4-93.2%). In elderly ≥65 years, 9V and 23F decreased from 3.8% to 0.3% (P=0.01) and from 18.9% to 7.4% (P <0.01), respectively while 7F increased significantly from 0% to 4.1% (P=0.04) over the same periods. Among isolates from aged <5 years, dual penicillin/erythromycin resistance increased from 44.1% to 64.2% (P=0.01). The types that often had dual penicillin/erythromycin resistance were 6B, 14, 19F, 23F, 6A and 19A. The emergence of serotype 19A was associated with expansion of sequence type 320. © 2011 Elsevier Ltd. |
| ISSN | 0264-410X 2011 Impact Factor: 3.766 2011 SCImago Journal Rankings: 0.369 |
| DOI | http://dx.doi.org/10.1016/j.vaccine.2011.02.025 |
| References | References in Scopus |
| dc.contributor.author | Ho, PL | ||||
|---|---|---|---|---|---|
| dc.contributor.author | Chiu, SS | ||||
| dc.contributor.author | Ang, I | ||||
| dc.contributor.author | Lau, YL | ||||
| dc.date.accessioned | 2011-07-27T01:33:42Z | ||||
| dc.date.available | 2011-07-27T01:33:42Z | ||||
| dc.date.issued | 2011 | ||||
| dc.description.abstract | This study analyzed 828 isolates causing invasive pneumococcal disease (IPD) before (1995-2001, n=265) and after (2007-2009, n=563) the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in Hong Kong. In children <5 years, serotype 14 had declined (36-15.7%, P<0.01) while 19A had increased (0-12.9%, P<0.01) in the before and after periods, respectively. In children aged <5 years, the proportion of PCV7 serotypes declined from 89.5% to 65.7% (72.8% if included cross protection against 6A) with time but that of PCV13 serotypes remained stable (91.4-93.2%). In elderly ≥65 years, 9V and 23F decreased from 3.8% to 0.3% (P=0.01) and from 18.9% to 7.4% (P <0.01), respectively while 7F increased significantly from 0% to 4.1% (P=0.04) over the same periods. Among isolates from aged <5 years, dual penicillin/erythromycin resistance increased from 44.1% to 64.2% (P=0.01). The types that often had dual penicillin/erythromycin resistance were 6B, 14, 19F, 23F, 6A and 19A. The emergence of serotype 19A was associated with expansion of sequence type 320. © 2011 Elsevier Ltd. | ||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||
| dc.identifier.citation | Vaccine, 2011, v. 29 n. 17, p. 3270-3275 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.vaccine.2011.02.025 | ||||
| dc.identifier.citeulike | 8888203 | ||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.vaccine.2011.02.025 | ||||
| dc.identifier.epage | 3275 | ||||
| dc.identifier.hkuros | 187585 | ||||
| dc.identifier.isi | WOS:000290603100027
Funding Information: This study is supported by research grants from the Research Fund for the Control of Infectious Diseases of the Food and Health Bureau of the Hong Kong SAR Government. Authors had no conflict of interest to declare. | ||||
| dc.identifier.issn | 0264-410X 2011 Impact Factor: 3.766 2011 SCImago Journal Rankings: 0.369 | ||||
| dc.identifier.issue | 17 | ||||
| dc.identifier.openurl | | ||||
| dc.identifier.pmid | 21352937 | ||||
| dc.identifier.scopus | eid_2-s2.0-79954603483 | ||||
| dc.identifier.spage | 3270 | ||||
| dc.identifier.uri | http://hdl.handle.net/10722/135336 | ||||
| dc.identifier.volume | 29 | ||||
| dc.language | eng | ||||
| dc.publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine | ||||
| dc.publisher.place | United Kingdom | ||||
| dc.relation.ispartof | Vaccine | ||||
| dc.relation.references | References in Scopus | ||||
| dc.subject.mesh | Anti-Bacterial Agents - pharmacology | ||||
| dc.subject.mesh | Bacterial Typing Techniques | ||||
| dc.subject.mesh | Pneumococcal Infections - epidemiology - microbiology | ||||
| dc.subject.mesh | Pneumococcal Vaccines - administration and dosage - immunology | ||||
| dc.subject.mesh | Streptococcus pneumoniae - classification - drug effects - immunology - isolation and purification | ||||
| dc.subject | Drug resistance | ||||
| dc.subject | Heptavalent pneumococcal conjugate vaccine | ||||
| dc.subject | Serotype replacement | ||||
| dc.subject | Streptococcus pneumoniae | ||||
| dc.title | Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009 | ||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong