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Article: Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009
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TitleSerotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009
 
AuthorsHo, PL1
Chiu, SS1
Ang, I1
Lau, YL1
 
KeywordsDrug resistance
Heptavalent pneumococcal conjugate vaccine
Serotype replacement
Streptococcus pneumoniae
 
Issue Date2011
 
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
 
CitationVaccine, 2011, v. 29 n. 17, p. 3270-3275 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.vaccine.2011.02.025
 
AbstractThis study analyzed 828 isolates causing invasive pneumococcal disease (IPD) before (1995-2001, n=265) and after (2007-2009, n=563) the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in Hong Kong. In children <5 years, serotype 14 had declined (36-15.7%, P<0.01) while 19A had increased (0-12.9%, P<0.01) in the before and after periods, respectively. In children aged <5 years, the proportion of PCV7 serotypes declined from 89.5% to 65.7% (72.8% if included cross protection against 6A) with time but that of PCV13 serotypes remained stable (91.4-93.2%). In elderly ≥65 years, 9V and 23F decreased from 3.8% to 0.3% (P=0.01) and from 18.9% to 7.4% (P <0.01), respectively while 7F increased significantly from 0% to 4.1% (P=0.04) over the same periods. Among isolates from aged <5 years, dual penicillin/erythromycin resistance increased from 44.1% to 64.2% (P=0.01). The types that often had dual penicillin/erythromycin resistance were 6B, 14, 19F, 23F, 6A and 19A. The emergence of serotype 19A was associated with expansion of sequence type 320. © 2011 Elsevier Ltd.
 
ISSN0264-410X
2013 Impact Factor: 3.485
 
DOIhttp://dx.doi.org/10.1016/j.vaccine.2011.02.025
 
ISI Accession Number IDWOS:000290603100027
Funding AgencyGrant Number
Food and Health Bureau of the Hong Kong SAR Government
Funding Information:

This study is supported by research grants from the Research Fund for the Control of Infectious Diseases of the Food and Health Bureau of the Hong Kong SAR Government. Authors had no conflict of interest to declare.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHo, PL
 
dc.contributor.authorChiu, SS
 
dc.contributor.authorAng, I
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2011-07-27T01:33:42Z
 
dc.date.available2011-07-27T01:33:42Z
 
dc.date.issued2011
 
dc.description.abstractThis study analyzed 828 isolates causing invasive pneumococcal disease (IPD) before (1995-2001, n=265) and after (2007-2009, n=563) the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in Hong Kong. In children <5 years, serotype 14 had declined (36-15.7%, P<0.01) while 19A had increased (0-12.9%, P<0.01) in the before and after periods, respectively. In children aged <5 years, the proportion of PCV7 serotypes declined from 89.5% to 65.7% (72.8% if included cross protection against 6A) with time but that of PCV13 serotypes remained stable (91.4-93.2%). In elderly ≥65 years, 9V and 23F decreased from 3.8% to 0.3% (P=0.01) and from 18.9% to 7.4% (P <0.01), respectively while 7F increased significantly from 0% to 4.1% (P=0.04) over the same periods. Among isolates from aged <5 years, dual penicillin/erythromycin resistance increased from 44.1% to 64.2% (P=0.01). The types that often had dual penicillin/erythromycin resistance were 6B, 14, 19F, 23F, 6A and 19A. The emergence of serotype 19A was associated with expansion of sequence type 320. © 2011 Elsevier Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationVaccine, 2011, v. 29 n. 17, p. 3270-3275 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.vaccine.2011.02.025
 
dc.identifier.citeulike8888203
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.vaccine.2011.02.025
 
dc.identifier.eissn1873-2518
 
dc.identifier.epage3275
 
dc.identifier.hkuros187585
 
dc.identifier.isiWOS:000290603100027
Funding AgencyGrant Number
Food and Health Bureau of the Hong Kong SAR Government
Funding Information:

This study is supported by research grants from the Research Fund for the Control of Infectious Diseases of the Food and Health Bureau of the Hong Kong SAR Government. Authors had no conflict of interest to declare.

 
dc.identifier.issn0264-410X
2013 Impact Factor: 3.485
 
dc.identifier.issue17
 
dc.identifier.openurl
 
dc.identifier.pmid21352937
 
dc.identifier.scopuseid_2-s2.0-79954603483
 
dc.identifier.spage3270
 
dc.identifier.urihttp://hdl.handle.net/10722/135336
 
dc.identifier.volume29
 
dc.languageeng
 
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofVaccine
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnti-Bacterial Agents - pharmacology
 
dc.subject.meshBacterial Typing Techniques
 
dc.subject.meshPneumococcal Infections - epidemiology - microbiology
 
dc.subject.meshPneumococcal Vaccines - administration and dosage - immunology
 
dc.subject.meshStreptococcus pneumoniae - classification - drug effects - immunology - isolation and purification
 
dc.subjectDrug resistance
 
dc.subjectHeptavalent pneumococcal conjugate vaccine
 
dc.subjectSerotype replacement
 
dc.subjectStreptococcus pneumoniae
 
dc.titleSerotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong