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Article: Age-Matched comparison of children hospitalized for 2009 pandemic H1N1 influenza with those hospitalized for seasonal H1N1 and H3N2
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TitleAge-Matched comparison of children hospitalized for 2009 pandemic H1N1 influenza with those hospitalized for seasonal H1N1 and H3N2
 
AuthorsChiu, SS1
Chan, KH1
Wong, WHS1
Chan, ELY1
Peiris, JSM1 2
 
Issue Date2011
 
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
CitationPlos One, 2011, v. 6 n. 7 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0021837
 
AbstractBackground: A wide spectrum of clinical manifestation ranging from deaths to a mild course of disease has been reported in children infected with the 2009 pandemic H1N1 (pH1N1) influenza. Methodology/Major Findings: We conducted an age-matched control study comparing children hospitalized for pH1N1 with historic controls infected with seasonal H1N1 and H3N2 influenza to correct for the effect of age on disease susceptibility and clinical manifestations. We also compared children with pH1N1 to children concurrently admitted for seasonal influenza during the pandemic period to adjust for differences in health-seeking behavior during the pandemic or other potential bias associated with historic controls. There was no death or intensive care admission. Children with pH1N1 were more likely to have at least one risk condition for influenza, an underlying chronic pulmonary condition, more likely to have asthma exacerbation and to be treated with oseltamivir. There was no difference in other aspects of the clinical course or outcome. Conclusion: Disease manifestation of children hospitalized for pH1N1 infection was mild in our patient population. © 2011 Chiu et al.
 
ISSN1932-6203
2012 Impact Factor: 3.73
2012 SCImago Journal Rankings: 1.512
 
DOIhttp://dx.doi.org/10.1371/journal.pone.0021837
 
PubMed Central IDPMC3140491
 
ISI Accession Number IDWOS:000292931200014
Funding AgencyGrant Number
Area of Excellence of University Grants CommitteeAoE/M-12/06
Funding Information:

This work was supported by the Area of Excellence Scheme of the University Grants Committee (grant AoE/M-12/06). The funders had no role in study design, data collection and analaysis, decision to publish, or preparation of the manuscript.

 
ReferencesReferences in Scopus
 
GrantsControl of Pandemic and Inter-pandemic Influenza
 
DC FieldValue
dc.contributor.authorChiu, SS
 
dc.contributor.authorChan, KH
 
dc.contributor.authorWong, WHS
 
dc.contributor.authorChan, ELY
 
dc.contributor.authorPeiris, JSM
 
dc.date.accessioned2011-07-27T01:33:41Z
 
dc.date.available2011-07-27T01:33:41Z
 
dc.date.issued2011
 
dc.description.abstractBackground: A wide spectrum of clinical manifestation ranging from deaths to a mild course of disease has been reported in children infected with the 2009 pandemic H1N1 (pH1N1) influenza. Methodology/Major Findings: We conducted an age-matched control study comparing children hospitalized for pH1N1 with historic controls infected with seasonal H1N1 and H3N2 influenza to correct for the effect of age on disease susceptibility and clinical manifestations. We also compared children with pH1N1 to children concurrently admitted for seasonal influenza during the pandemic period to adjust for differences in health-seeking behavior during the pandemic or other potential bias associated with historic controls. There was no death or intensive care admission. Children with pH1N1 were more likely to have at least one risk condition for influenza, an underlying chronic pulmonary condition, more likely to have asthma exacerbation and to be treated with oseltamivir. There was no difference in other aspects of the clinical course or outcome. Conclusion: Disease manifestation of children hospitalized for pH1N1 infection was mild in our patient population. © 2011 Chiu et al.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationPlos One, 2011, v. 6 n. 7 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0021837
 
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0021837
 
dc.identifier.eissn1932-6203
 
dc.identifier.epagee21837
 
dc.identifier.hkuros186890
 
dc.identifier.isiWOS:000292931200014
Funding AgencyGrant Number
Area of Excellence of University Grants CommitteeAoE/M-12/06
Funding Information:

This work was supported by the Area of Excellence Scheme of the University Grants Committee (grant AoE/M-12/06). The funders had no role in study design, data collection and analaysis, decision to publish, or preparation of the manuscript.

 
dc.identifier.issn1932-6203
2012 Impact Factor: 3.73
2012 SCImago Journal Rankings: 1.512
 
dc.identifier.issue7
 
dc.identifier.pmcidPMC3140491
 
dc.identifier.pmid21799750
 
dc.identifier.scopuseid_2-s2.0-79960575044
 
dc.identifier.spagee21837
 
dc.identifier.urihttp://hdl.handle.net/10722/135333
 
dc.identifier.volume6
 
dc.languageeng
 
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
dc.publisher.placeUnited States
 
dc.relation.ispartofPLoS ONE
 
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshHospitalization - statistics and numerical data
 
dc.subject.meshInfluenza A Virus, H1N1 Subtype - pathogenicity
 
dc.subject.meshInfluenza A Virus, H3N2 Subtype - pathogenicity
 
dc.subject.meshInfluenza, Human - complications - diagnosis - epidemiology - therapy
 
dc.subject.meshPandemics - statistics and numerical data
 
dc.titleAge-Matched comparison of children hospitalized for 2009 pandemic H1N1 influenza with those hospitalized for seasonal H1N1 and H3N2
 
dc.typeArticle
 
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<description.abstract>Background: A wide spectrum of clinical manifestation ranging from deaths to a mild course of disease has been reported in children infected with the 2009 pandemic H1N1 (pH1N1) influenza. Methodology/Major Findings: We conducted an age-matched control study comparing children hospitalized for pH1N1 with historic controls infected with seasonal H1N1 and H3N2 influenza to correct for the effect of age on disease susceptibility and clinical manifestations. We also compared children with pH1N1 to children concurrently admitted for seasonal influenza during the pandemic period to adjust for differences in health-seeking behavior during the pandemic or other potential bias associated with historic controls. There was no death or intensive care admission. Children with pH1N1 were more likely to have at least one risk condition for influenza, an underlying chronic pulmonary condition, more likely to have asthma exacerbation and to be treated with oseltamivir. There was no difference in other aspects of the clinical course or outcome. Conclusion: Disease manifestation of children hospitalized for pH1N1 infection was mild in our patient population. &#169; 2011 Chiu et al.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. HKU-Pasteur Research Centre