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Article: Reversible leukoencephalopathy following intrathecal methotrexate

TitleReversible leukoencephalopathy following intrathecal methotrexate
Authors
KeywordsIntrathecal
Leukoencephalopathy
Magnetic resonance imaging
Methotrexate
Issue Date2010
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2010, v. 15 n. 4, p. 327-331 How to Cite?
AbstractLeukoencephalopathy is a severe but often reversible neurological complication with high dose intravenous methotrexate (MTX). It is much rarer after intrathecal MTX. We report a 13-year-old girl suffered from leukoencephalopathy 7 days after intrathecal MTX administration. The sequential MRI changes are highlighted in this report. Rescue therapy with aminophylline and high-dose folinic acid was given for 10 days. Her neurological status in terms of the speech and motor function gradually improved afterwards.
Persistent Identifierhttp://hdl.handle.net/10722/135325
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123
References

 

DC FieldValueLanguage
dc.contributor.authorXiong, Hen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorChiang, AKSen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorHu, Qen_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2011-07-27T01:33:37Z-
dc.date.available2011-07-27T01:33:37Z-
dc.date.issued2010en_HK
dc.identifier.citationHong Kong Journal Of Paediatrics, 2010, v. 15 n. 4, p. 327-331en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135325-
dc.description.abstractLeukoencephalopathy is a severe but often reversible neurological complication with high dose intravenous methotrexate (MTX). It is much rarer after intrathecal MTX. We report a 13-year-old girl suffered from leukoencephalopathy 7 days after intrathecal MTX administration. The sequential MRI changes are highlighted in this report. Rescue therapy with aminophylline and high-dose folinic acid was given for 10 days. Her neurological status in terms of the speech and motor function gradually improved afterwards.en_HK
dc.languageengen_US
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.rightsDOAJen_US
dc.subjectIntrathecalen_HK
dc.subjectLeukoencephalopathyen_HK
dc.subjectMagnetic resonance imagingen_HK
dc.subjectMethotrexateen_HK
dc.titleReversible leukoencephalopathy following intrathecal methotrexateen_HK
dc.typeArticleen_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-78149451909en_HK
dc.identifier.hkuros186674en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78149451909&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue4en_HK
dc.identifier.spage327en_HK
dc.identifier.epage331en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridXiong, H=36438003100en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridHu, Q=35080358400en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK

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