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Article: The use of brushite calcium phosphate cement for enhancement of bone-tendon integration in an anterior cruciate ligament reconstruction rabbit model

TitleThe use of brushite calcium phosphate cement for enhancement of bone-tendon integration in an anterior cruciate ligament reconstruction rabbit model
Authors
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/
Citation
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2009, v. 89 n. 2, p. 466-474 How to Cite?
AbstractThis study was designed to investigate the osteoconductivity and bioresorption of brushite calcium phosphate cement (CPC) in bone-tendon interface healing after anterior cruciate ligament (ACL) reconstruction. Surgical reconstruction using grafted tendon in bone tunnel was performed bilaterally in 28 skeletal mature rabbits. Brushite CPC was implanted between grafted tendon and bone tunnel of one limb with the contralateral one as the control. A batch of 14 rabbits was sacrificed at 6 and 12 weeks, respectively, after surgery. At each time point, six rabbits were used for micro-CT and subsequent histological examinations, whereas the remaining eight rabbits were used for pull-out testing. The components of brushite CPC-dicalcium phosphate dihydrate matrix degraded rapidly with beta-tricalcium phosphate granules left for guiding new bone formation. Brushite CPC augmented the peri-tendon bone volume and promoted bone growth into the healing interface. The ultimate strength and stiffness of the graft-tunnel complexes on experimental side was higher than that of the control by 117% and 102%, respectively, at 6 weeks postoperatively (p < 0.05 for both). The use of brushite CPC caused a paradigm shift in failure mode from intra-tunnel to intra-articular portion at 12 weeks postoperatively (p = 0.013). Brushite CPC significantly enhanced the bone-tendon integration after ACL reconstruction, which provided a scientific basis for clinical application. © 2008 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/135303
ISSN
2015 Impact Factor: 2.881
2015 SCImago Journal Rankings: 0.784
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant Council, Hong Kong SAR, China06-07
CUHK4497/06M
Funding Information:

Contract grant sponsor: Research Grant Council Earmarked Grants 06-07. Hong Kong SAR, China: Contract grant number: CUHK4497/06M

 

DC FieldValueLanguage
dc.contributor.authorWen, CYen_US
dc.contributor.authorQin, Len_US
dc.contributor.authorLee, KMen_US
dc.contributor.authorChan, KMen_US
dc.date.accessioned2011-07-27T01:31:49Z-
dc.date.available2011-07-27T01:31:49Z-
dc.date.issued2009en_US
dc.identifier.citationJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2009, v. 89 n. 2, p. 466-474en_US
dc.identifier.issn1552-4973en_US
dc.identifier.urihttp://hdl.handle.net/10722/135303-
dc.description.abstractThis study was designed to investigate the osteoconductivity and bioresorption of brushite calcium phosphate cement (CPC) in bone-tendon interface healing after anterior cruciate ligament (ACL) reconstruction. Surgical reconstruction using grafted tendon in bone tunnel was performed bilaterally in 28 skeletal mature rabbits. Brushite CPC was implanted between grafted tendon and bone tunnel of one limb with the contralateral one as the control. A batch of 14 rabbits was sacrificed at 6 and 12 weeks, respectively, after surgery. At each time point, six rabbits were used for micro-CT and subsequent histological examinations, whereas the remaining eight rabbits were used for pull-out testing. The components of brushite CPC-dicalcium phosphate dihydrate matrix degraded rapidly with beta-tricalcium phosphate granules left for guiding new bone formation. Brushite CPC augmented the peri-tendon bone volume and promoted bone growth into the healing interface. The ultimate strength and stiffness of the graft-tunnel complexes on experimental side was higher than that of the control by 117% and 102%, respectively, at 6 weeks postoperatively (p < 0.05 for both). The use of brushite CPC caused a paradigm shift in failure mode from intra-tunnel to intra-articular portion at 12 weeks postoperatively (p = 0.013). Brushite CPC significantly enhanced the bone-tendon integration after ACL reconstruction, which provided a scientific basis for clinical application. © 2008 Wiley Periodicals, Inc.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/-
dc.relation.ispartofJournal of Biomedical Materials Research Part B: Applied Biomaterialsen_US
dc.rightsJournal of Biomedical Materials Research Part B: Applied Biomaterials. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshAnterior Cruciate Ligament - pathology - surgery-
dc.subject.meshBone Cements - chemistry - metabolism-
dc.subject.meshCalcium Phosphates - chemistry - metabolism-
dc.subject.meshReconstructive Surgical Procedures-
dc.subject.meshTendons - cytology - metabolism - transplantation-
dc.titleThe use of brushite calcium phosphate cement for enhancement of bone-tendon integration in an anterior cruciate ligament reconstruction rabbit modelen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1552-4973&volume=89&issue=2&spage=466&epage=474&date=2009&atitle=The+use+of+brushite+calcium+phosphate+cement+for+enhancement+of+bone-tendon+integration+in+an+anterior+cruciate+ligament+reconstruction+rabbit+modelen_US
dc.identifier.emailWen, CY: paulwen@hku.hken_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.b.31236-
dc.identifier.pmid18937262-
dc.identifier.scopuseid_2-s2.0-65949122937-
dc.identifier.hkuros188832en_US
dc.identifier.volume89en_US
dc.identifier.issue2en_US
dc.identifier.spage466en_US
dc.identifier.epage474en_US
dc.identifier.isiWOS:000265445000021-

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